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Chapter 25 - Management of Fertility for the Trans Masculine Individual

from Section E - Fertility and Reproduction

Published online by Cambridge University Press:  22 December 2022

Mick van Trotsenburg
Affiliation:
Sigmund Freud PrivatUniversität, Wien
Rixt A. C. Luikenaar
Affiliation:
Rebirth Health Center, Utah
Maria Cristina Meriggiola
Affiliation:
Università di Bologna
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Summary

Multiple factors should be considered when counseling trans masculine (TM) individuals on fertility preservation (FP) options, including age at referral, presence of dysphoria, anticipated timeline for gender-affirming treatment (GAT), timeline for desired children, presence of a partner, partner’s reproductive organs, and the individual (or partner’s) desire to carry a pregnancy [1]. Additionally, it is important to counsel patients on the interventions required in order to use their cryopreserved gametes in the future and expected costs associated with these procedures [2].

Type
Chapter
Information
Context, Principles and Practice of TransGynecology
Managing Transgender Patients in ObGyn Practice
, pp. 190 - 193
Publisher: Cambridge University Press
Print publication year: 2022

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References

Sundaram, V, Mok-Lin, E. Fertility preservation for the transgender individual. Curr Obstet Gynecol Rep 2020;9:129137.Google Scholar
Moravek, MB. Fertility preservation options for transgender and gender-nonconforming individuals. Curr Opin Obstet Gynecol 2019;31(3):170176.CrossRefGoogle ScholarPubMed
La Marca, A, Volpe, A. Anti-Mullerian hormone (AMH) in female reproduction: is measurement of circulating AMH a useful tool? Clin Endocrinol 2006;64:603610.Google Scholar
Hansen, KR, Hodnett, GM, Knowlton, N, et al. Correlation of ovarian reserve tests with histologically determined primordial follicle number. Fertil Steril 2011;95:170175.CrossRefGoogle ScholarPubMed
Mattawanon, N, Spencer, JB, Schirmer, DA, Tangpricha, V. Fertility preservation options in transgender people: a review. Rev Endocr Metab Disord 2018;19(3):231242.Google Scholar
Moravek, MB, Kinnear, HM, George, J, et al. Impact of exogenous testosterone on reproduction in transgender men. Endocrinology 2020;161(3):bqaa014.CrossRefGoogle ScholarPubMed
Adeleye, AJ, Cedars, MI, Smith, J, Mok-Lin, E. Ovarian stimulation for fertility preservation or family building in a cohort of transgender men. J Assist Reprod Genet 2019;36(10):21552161.CrossRefGoogle ScholarPubMed
Lee, DE, Park, SY, Lee, SR, Jeong, K, Chung, HW. Diagnostic usefulness of transrectal ultrasound compared with transvaginal ultrasound assessment in young Korean women with polycystic ovary syndrome. J Menopausal Med 2015;21(3):149.CrossRefGoogle ScholarPubMed
Timor-Tritsch, IE, Monteagudo, A, Rebarber, A, Goldstein, SR, Tsymbal, T. Transrectal scanning: an alternative when transvaginal scanning is not feasible. Ultrasound Obstet Gynecol 2003;21(5):473479.Google Scholar
Daar, J, Benward, J, Collins, L, et al. Planned oocyte cryopreservation for women seeking to preserve future reproductive potential: an Ethics Committee opinion. Fertil Steril 2018;110(6):10221028.CrossRefGoogle Scholar
De Sutter, P. Gender reassignment and assisted reproduction. Hum Reprod 2001;16(4):612614.Google Scholar
Wallace, SA, Blough, KL, Kondapalli, LA. Fertility preservation in the transgender patient: expanding oncofertility care beyond cancer. Gynecol Endocrinol 2014;30(12):868871.CrossRefGoogle ScholarPubMed
Wallace, SA, Blough, KL, Kondapalli, LA. Fertility preservation in the transgender patient: expanding oncofertility care beyond cancer. Gynecol Endocrinol 2014;30(12):868871.Google Scholar
Maxwell, S, Noyes, N, Keefe, D, Berkeley, AS, Goldman, KN. Pregnancy outcomes after fertility preservation in transgender men. Obstet Gynecol 2017;129(6):10311034.Google Scholar
Chen, D, Bernardi, LA, Pavone, ME, Feinberg, EC, Moravek, MB. Oocyte cryopreservation among transmasculine youth: a case series. J Assist Reprod Genet 2018;35(11):20572061.CrossRefGoogle ScholarPubMed
De Roo, C, Tilleman, K, T’Sjoen, G, De Sutter, P. Fertility options in transgender people. Int Rev Psychiatry 2016;28(1):112119.CrossRefGoogle ScholarPubMed
Light, AD, Obedin-Maliver, J, Sevelius, JM, Kerns, JL. Transgender men who experienced pregnancy after female-to-male gender transitioning. Obstet Gynecol 2014;124(6):11201127.Google Scholar
Armuand, G, Dhejne, C, Olofsson, JI, Rodriguez-Wallberg, KA. Transgender men’s experiences of fertility preservation: a qualitative study. Hum Reprod 2017;32(2):383390.CrossRefGoogle ScholarPubMed
Padmanabhan, V, Veiga-Lopez, A. Animal models of the polycystic ovary syndrome phenotype. Steroids 2013;78(8):734740.CrossRefGoogle ScholarPubMed
Shi, D, Vine, DF. Animal models of polycystic ovary syndrome: a focused review of rodent models in relationship to clinical phenotypes and cardiometabolic risk. Fertil Steril 2012;98(1):185–193.e2.Google Scholar
Kinnear, HM, Constance, ES, David, A, et al. A mouse model to investigate the impact of testosterone therapy on reproduction in transgender men. Hum Reprod 2019;34(10):20092017.Google Scholar
Ikeda, K, Baba, T, Noguchi, H, et al. Excessive androgen exposure in female-to-male transsexual persons of reproductive age induces hyperplasia of the ovarian cortex and stroma but not polycystic ovary morphology. Hum Reprod 2013;28(2):453461.CrossRefGoogle Scholar
Futterweit, W, Deligdisch, L. Histopathological effects of exogenously administered testosterone in 19 female to male transsexuals. J Clin Endocrinol Metab 1986;62(1):1621.Google Scholar
Chadha, S, Pache, TD, Huikeshoven, FJM, Brinkmann, AO, van derKwast, TH. Androgen receptor expression in human ovarian and uterine tissue of long-term androgen-treated transsexual women. Hum Pathol 1994;25(11):11981204.CrossRefGoogle ScholarPubMed
Leung, A, Sakkas, D, Pang, S, Thornton, K, Resetkova, N. Assisted reproductive technology outcomes in female-to-male transgender patients compared with cisgender patients: a new frontier in reproductive medicine. Fertil Steril 2019;112(5):858865.Google Scholar
Fabregues, F, Peñarrubia, J, Creus, M, et al. Transdermal testosterone may improve ovarian response to gonadotrophins in low-responder IVF patients: a randomized, clinical trial. Hum Reprod 2009;24(2):349359.CrossRefGoogle ScholarPubMed
Cobo, A, Garcia-Velasco, JA, Domingo, J, Remohí, J, Pellicer, A. Is vitrification of oocytes useful for fertility preservation for age-related fertility decline and in cancer patients? Fertil Steril 2013;99(6):14851495.Google Scholar
Wierckx, K, Elaut, E, Van Hoorde, B, et al. Sexual desire in trans persons: associations with sex reassignment treatment. J Sex Med 2014;11(1):107118.CrossRefGoogle ScholarPubMed
Cho, K, Harjee, R, Roberts, J, et al. Fertility preservation in a transgender man without prolonged discontinuation of testosterone: a case report and literature review. F&S Rep 2020;1(1):4347.Google Scholar
Oktay, K, Turan, V, Bedoschi, G, Pacheco, FS, Moy, F. Fertility preservation success subsequent to concurrent aromatase inhibitor treatment and ovarian stimulation in women with breast cancer. J Clin Oncol 2015;33(22):24242429.CrossRefGoogle ScholarPubMed
Fasano, G, Moffa, F, Dechène, J, Englert, Y, Demeestere, I. Vitrification of in vitro matured oocytes collected from antral follicles at the time of ovarian tissue cryopreservation. Reprod Biol Endocrinol 2011;9(1):150.CrossRefGoogle ScholarPubMed
Segers, I, Mateizel, I, Van Moer, E, et al. In vitro maturation (IVM) of oocytes recovered from ovariectomy specimens in the laboratory: a promising “ex vivo” method of oocyte cryopreservation resulting in the first report of an ongoing pregnancy in Europe. J Assist Reprod Genet 2015;32(8):12211231.CrossRefGoogle ScholarPubMed
De Roo, C, Lierman, S, Tilleman, K, et al. Ovarian tissue cryopreservation in female-to-male transgender people: insights into ovarian histology and physiology after prolonged androgen treatment. Reprod Biomed Online 2017;34(6):557566.Google Scholar
Lierman, S, Tilleman, K, Braeckmans, K, et al. Fertility preservation for trans men: frozen-thawed in vitro matured oocytes collected at the time of ovarian tissue processing exhibit normal meiotic spindles. J Assist Reprod Genet 2017;34(11):14491456.CrossRefGoogle ScholarPubMed
Telfer, EE. Future developments: in vitro growth (IVG) of human ovarian follicles. Acta Obstet Gynecol Scand 2019;98(5):653658.Google Scholar

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