Book contents
- Frontmatter
- Contents
- Contributors
- Foreword
- Acknowledgements
- Biographical note on F. H. Lewy
- Abbreviations
- Group photograph
- Introduction
- Part one Clinical issues
- Part two Pathological issues
- 15 Pathological significance of Lewy bodies in dementia
- 16 Tautological tangles in neuropathologic criteria for dementias associated with Lewy bodies
- 17 What is the neuropathological basis of dementia associated with Lewy bodies?
- 18 Cytoskeletal and Alzheimer-type pathology in Lewy body disease
- 19 Diffuse Lewy body disease within the spectrum of Lewy body disease
- 20 Temporal lobe immunohistochemical pathology for tangles, plaques and Lewy bodies in diffuse Lewy body disease, Parkinson's disease, and senile dementia of Alzheimer type
- 21 Pathological and clinical features of Parkinson's disease with and without dementia
- 22 Dementia with Lewy bodies: relationships to Parkinson's and Alzheimer's diseases
- 23 What do Lewy bodies tell us about dementia and parkinsonism?
- 24 Pathogenesis of the Lewy body
- 25 Altered tau processing: its role in development of dementia in Alzheimer's disease and Lewy body disease
- 26 Cytoskeletal pathology in Alzheimer's disease and Lewy body dementia – an epiphenomenon?
- 27 Genetic correlations in Lewy body disease
- Résumeacute; of pathological workshop sessions
- Part three Treatment issues
- Appendices
- Index
- Plate section
16 - Tautological tangles in neuropathologic criteria for dementias associated with Lewy bodies
from Part two - Pathological issues
Published online by Cambridge University Press: 06 July 2010
- Frontmatter
- Contents
- Contributors
- Foreword
- Acknowledgements
- Biographical note on F. H. Lewy
- Abbreviations
- Group photograph
- Introduction
- Part one Clinical issues
- Part two Pathological issues
- 15 Pathological significance of Lewy bodies in dementia
- 16 Tautological tangles in neuropathologic criteria for dementias associated with Lewy bodies
- 17 What is the neuropathological basis of dementia associated with Lewy bodies?
- 18 Cytoskeletal and Alzheimer-type pathology in Lewy body disease
- 19 Diffuse Lewy body disease within the spectrum of Lewy body disease
- 20 Temporal lobe immunohistochemical pathology for tangles, plaques and Lewy bodies in diffuse Lewy body disease, Parkinson's disease, and senile dementia of Alzheimer type
- 21 Pathological and clinical features of Parkinson's disease with and without dementia
- 22 Dementia with Lewy bodies: relationships to Parkinson's and Alzheimer's diseases
- 23 What do Lewy bodies tell us about dementia and parkinsonism?
- 24 Pathogenesis of the Lewy body
- 25 Altered tau processing: its role in development of dementia in Alzheimer's disease and Lewy body disease
- 26 Cytoskeletal pathology in Alzheimer's disease and Lewy body dementia – an epiphenomenon?
- 27 Genetic correlations in Lewy body disease
- Résumeacute; of pathological workshop sessions
- Part three Treatment issues
- Appendices
- Index
- Plate section
Summary
Summary
Only a minority of Lewy body dementia brains lack concomitant Alzheimer disease pathology, but the percentages of combined Lewy body disease and Alzheimer disease versus pure Lewy body disease vary depending upon what neuropathological criteria are employed to make a diagnosis of Alzheimer disease. Using criteria from the Consortium to Establish a Registry for Alzheimer Disease, nearly 90% of all Lewy body dementia brains have definite or probable Alzheimer disease. Such Lewy body variants of Alzheimer disease also show medial temporal lobe neurofibrillary pathology intermediate in severity between that seen in pure Alzheimer disease and that encountered in elderly nondemented controls or pure Lewy body disease patients. Like Alzheimer disease, but unlike pure Lewy body disease, Lewy body variants of Alzheimer disease have an increased apolipoprotein ∈4 allelic frequency. If myriads of neocortical neurofibrillary tangles are deemed requisite for a diagnosis of Alzheimer disease, the percentage of mixed Alzheimer disease and Lewy body disease falls from 89% of all Lewy body dementia brains to 32%. Even in the absence of concomitant Alzheimer disease pathology, nosologic uncertainty persists in Lewy body disease since no established neuropathologic criteria can reliably distinguish pure Parkinson's disease from so-called diffuse Lewy body disease.
Introduction
‘When I use a word’, Humpty Dumpty said in a rather scornful tone ‘It means just what I choose it to mean – neither more nor less.’ ‘The question is,’ said Alice, ‘Whether you can make words mean so many different things.’ ‘The question,’ said Humpty Dumpty, ‘Is which is to be master – that's all.’
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- Information
- Dementia with Lewy BodiesClinical, Pathological, and Treatment Issues, pp. 204 - 211Publisher: Cambridge University PressPrint publication year: 1996
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