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4 - A Comparative Genetic Analysis of Acellular Cementum

from Part I - The Biology of Cementum

Published online by Cambridge University Press:  20 January 2022

By
Amber E. Trujillo ,
Alex R. DeCasien ,
Mareike C. Janiak ,
Stephan Naji  and
Todd R. Disotell
Edited by
Stephan Naji ,
William Rendu  and
Lionel Gourichon
Stephan Naji
Affiliation:
New York University
William Rendu
Affiliation:
University of Bordeaux (CNRS)
Lionel Gourichon
Affiliation:
Université de Nice, Sophia Antipolis
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Summary

This chapter details a comparative genetic analysis of several candidate genes associated with acellular cementum, namely ALPL, BMP-2, BMP-7, and ARNTL. More than 40 species of mammals, reptiles, and birds were included in this analysis. For each gene, we investigated the type of selection that best characterized its evolutionary history, identified species in which these genes were recently subject to positive selection, and demonstrated specific behavioral and morphological characteristics that influence the selection pressure on these genes. We found that, overall, ALPL, BMP-2, BMP-7, and ARNTL have been subject to purifying selection in the examined taxa; however, recent positive selection on three of these genes was identified in species that have experienced recent, rapid evolutionary changes in dental anatomy. In addition, we found that several species-specific characteristics, including diet, lifespan, tooth count, and radicularity, significantly predicted lineage-specific selection pressure on these genes. This chapter demonstrates that cementum genes have undergone significant evolutionary changes, and that certain phenotypic characteristics have influenced such changes

Keywords

Acellular cementumcomparative geneticsselection pressurecementogenesis
Type
Chapter
Information
Dental Cementum in Anthropology , pp. 83 - 93
Publisher: Cambridge University Press
Print publication year: 2022

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References

Baglinière, J.-L., Castanet, J., Conand, F. and Meunier, F. J. 1992. Terminologie en sclérochronologie chez les Vertébrés. In Baglinière, J.-L., Castanet, J., Conand, F., and Meunier, F. J., eds. Tissus durs et âge individuel des vertébrés, Paris: ORSTOM/INRA Editions, 443–47.Google Scholar
Bloch‐Zupan, A. 2016. Hypophosphatasia: Diagnosis and clinical signs – A dental surgeon perspective. International Journal of Paediatric Dentistry, 26(6): 426–38.CrossRefGoogle ScholarPubMed
Colard, T., Falgayrac, G., Bertrand, B., Naji, S., Devos, O., Balsack, C., Delannoy, Y., and Penel, G. 2016. New insights on the composition and the structure of the acellular extrinsic fiber cementum by Raman analysis. PloS One, 11(12): e0167316.CrossRefGoogle ScholarPubMed
Dumont, E. R. 2010. Bone density and the lightweight skeletons of birds. Proceedings of the Royal Society of London B: Biological Sciences, 277(1691): 2193–8.Google ScholarPubMed
Foster, B. L., Nagatomo, K. J., NocitiJr, F. H., Fong, H., Dunn, D., Tran, A. B., Wang, W., Narisawa, S., Millán, J. L. and Somerman, M. J. 2012. Central role of pyrophosphate in acellular cementum formation. PLoS One, 7(6): e38393.Google Scholar
Foster, B. L., Kuss, P., Yadav, M. C., Kolli, T. N., Narisawa, S., Lukashova, L., Cory, E., Sah, R. L., Somerman, M. J., and Millán, J. L. 2017. Conditional ALPL ablation phenocopies dental defects of hypophosphatasia. Journal of Dental Research, 96(1): 81–91.Google Scholar
Gaengler, P., and Metzier, E.. 1992. The periodontal differentiation in the phylogeny of teeth–an overview. Journal of Periodontal Research, 27(3): 214–25.Google Scholar
Garcia, R. A., and Zurriaguz, V. 2016. Histology of teeth and tooth attachment in titanosaurs (Dinosauria; Sauropoda). Cretaceous Research, 57: 248–56.CrossRefGoogle Scholar
Grue, H., and Jensen, B. 1979. Review of the formation of incremental lines in tooth cementum of terrestrial mammals. Danish Review of Game Biology (Denmark), 11(1979): 1–48.Google Scholar
Katoh, K., Rozewicki, J., and Yamada, K. D. 2019. MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. Briefings in Bioinformatics, 20(4): 116–66.Google Scholar
Kearse, M., Moir, R., Wilson, A., Stones-Havas, S., Cheung, M., Sturrock, S., Buxton, S., Cooper, A., Markowitz, S., Duran, C., Thierer, T., Ashton, B., Mentjies, P., and Drummond, A. 2012. Geneious Basic: an integrated and extendable desktop software platform for the organization and analysis of sequence data. Bioinformatics, 28(12): 1647–49.CrossRefGoogle ScholarPubMed
King, G. N., King, N., Cruchley, A. T., Wozney, J. M., and Hughes, F. J. 1997. Recombinant human bone morphogenetic protein-2 promotes wound healing in rat periodontal fenestration defects. Journal of Dental Research, 76(8): 1460–70.CrossRefGoogle ScholarPubMed
King, G. N., and Hughes, F. J. 1999. Effects of occlusal loading on ankylosis, bone, and cementum formation during bone morphogenetic protein-2-stimulated periodontal regeneration in vivo. Journal of Periodontology, 70(10): 1125–35.Google ScholarPubMed
King, G. N., and Hughes, F. J. 2001. Bone morphogenetic protein‐2 stimulates cell recruitment and cementogenesis during early wound healing. Journal of Clinical Periodontology, 28(5): 465–75.CrossRefGoogle ScholarPubMed
Klevezal’, G. A. 1996. Recording Structures of Mammals: Determination of Age and Reconstruction of Life History, Rotterdam: A. A. Balkema.Google Scholar
Koehne, T., Jeschke, A., Petermann, F., Seitz, S., Neven, M., Peters, S., Luther, J., Schweizer, M., Schinke, T., Kahl-Nieke, B., and Amling, M. 2016. Rsk2, the kinase mutated in Coffin-Lowry syndrome, controls cementum formation. Journal of Dental Research, 95(7): 752–60.CrossRefGoogle ScholarPubMed
Laws, R. M. 1952. A new method of age determination for mammals. Nature, 169(4310): 972.CrossRefGoogle ScholarPubMed
LeBlanc, A. R., and Reisz, R. R. 2013. Periodontal ligament, cementum, and alveolar bone in the oldest herbivorous tetrapods, and their evolutionary significance. PLoS One, 8(9): e74697.CrossRefGoogle ScholarPubMed
LeBlanc, A. R., Reisz, R. R., Brink, K. S., and Abdala, F. 2016. Mineralized periodontia in extinct relatives of mammals shed light on the evolutionary history of mineral homeostasis in periodontal tissue maintenance. Journal of Clinical Periodontology, 43(4): 323–32.Google Scholar
LeBlanc, A. R., Lamoureux, D. O. and Caldwell, M. W. 2017. Mosasaurs and snakes have a periodontal ligament: Timing and extent of calcification, not tissue complexity, determines tooth attachment mode in reptiles. Journal of Anatomy, 231(6): 869–85.CrossRefGoogle Scholar
LeBlanc, A. R., Brink, K. S., Cullen, T. M., and Reisz, R. R. 2017. Evolutionary implications of tooth attachment versus tooth implantation: A case study using dinosaur, crocodilian, and mammal teeth. Journal of Vertebrate Paleontology, 37(5): e1354006.Google Scholar
Lieberman, D. E. 1994. The biological basis for seasonal increments in dental cementum and their application to archaeological research. Journal of Archaeological Science, 21: 525–25.Google Scholar
Magitot, E. 1878. Treatise on Dental Caries: Experimental and Therapeutic Investigations. Houghton: Osgood and Company.Google Scholar
Millán, J. L. 2006. Alkaline phosphatases: Structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymes. Purinergic Signal, 2(2): 335–41.Google Scholar
Millán, J. L., and Whyte, M. P. 2016. Alkaline phosphatase and hypophosphatasia. Calcified Tissue International, 98(4): 398–416.CrossRefGoogle ScholarPubMed
Mornet, E., 2017. Genetics of hypophosphatasia. Archives de Pédiatrie, 24(5): 5S51–6.CrossRefGoogle ScholarPubMed
Murphy, M., Brown, G., Wallin, C., Tatusova, T., Pruitt, K., Murphy, T., and Maglott, D. 2018. Gene help: Integrated access to genes of genomes in the reference sequence collection. In Gene Help [Internet]. National Center for Biotechnology Information (US). www.ncbi.nlm.nih.gov/books/NBK3841Google Scholar
Naji, S., Colard, T., Blondiaux, J., Bertrand, B., d’Incau, E., and Bocquet-Appel, J.-P. 2016. Cementochronology, to cut or not to cut? International Journal of Paleopathology, 15: 113–9.Google Scholar
Reibel, A., Manière, M. C., Clauss, F., Droz, D., Alembik, Y., Mornet, E., and Bloch-Zupan, A. 2009. Orodental phenotype and genotype findings in all subtypes of hypophosphatasia. Orphanet Journal of Rare Diseases, 4(1): 6.CrossRefGoogle ScholarPubMed
Samuels, J. X. 2009. Cranial morphology and dietary habits of rodents. Zoological Journal of the Linnean Society, 156(4): 864–88.CrossRefGoogle Scholar
Smith, M. D., Wertheim, J. O., Weaver, S., Murrell, B., Scheffler, K., and Kosakovsky Pond, S. L. 2015. Less is more: An adaptive branch-site random effects model for efficient detection of episodic diversifying selection. Molecular Biology and Evolution, 32(5): 1342–53.Google Scholar
Spinage, C. A. 1976. Incremental cementum lines in the teeth of tropical African mammals. Journal of Zoology, 178(1): 117–31.Google Scholar
Stock, S. R., Finney, L. A., Telser, A., Maxey, E, Vogt, S., and Okasinski, J. S.. 2017. Cementum structure in Beluga whale teeth. Acta Biomaterialia, 48(2017): 289–99.Google Scholar
Stott, G. G., Sis, R. F., and Levy, B. M. 1982. Cemental annulation as an age criterion in forensic dentistry. Journal of Dental Research, 61(6): 814–17.Google Scholar
Thesleff, I. 2003. Developmental biology and building a tooth. Quintessence International, 34(8).Google ScholarPubMed
van den Bos, T., Handoko, G., Niehof, A., Ryan, L. M., Coburn, S. P., Whyte, M. P., and Beertsen, W. 2005. Cementum and dentin in hypophosphatasia. Journal of Dental Research, 84(11): 1021–25.Google Scholar
Whyte, M. P. 2016. Hypophosphatasia – Aetiology, nosology, pathogenesis, diagnosis and treatment. Nature Reviews Endocrinology, 12(4): 233.CrossRefGoogle ScholarPubMed
Whyte, M.P. 2017. Hypophosphatasia: An overview for 2017. Bone, 102: 15–25.Google Scholar
Yamamoto, H., Niimi, T., Yokota-Ohta, R., Suzuki, K., Sakae, T., and Kozawa, Y. 2009. Diversity of acellular and cellular cementum distribution in human permanent teeth. Journal of Hard Tissue Biology, 18(1): 40–44.CrossRefGoogle Scholar
Yamashiro, T., Tummers, M., and Thesleff, I. 2003. Expression of bone morphogenetic proteins and Msx genes during root formation. Journal of Dental Research, 82(3): 172–6.Google Scholar
Yan, J., Ma, Z., Xu, X., and Guo, A. Y. 2014. Evolution, functional divergence and conserved exon–intron structure of bHLH/PAS gene family. Molecular Genetics and Genomics, 289(1): 25–36.CrossRefGoogle ScholarPubMed
Yang, Z. 1997. PAML: A program package for phylogenetic analysis by maximum. Computer Applications in the Biosciences: CABIOS, 13(5): 555–6.Google Scholar
Zeichner, -David, M. 2006. Regeneration of periodontal tissues: Cementogenesis revisited. Periodontology 2000, 41(1): 196–217.Google Scholar
Zeuner, F. E. 1963. A History of Domesticated Animals. London: Harper & Row.Google Scholar
Zheng, L., Ehardt, L., McAlpin, B., About, I., Kim, D., Papagerakis, S., and Papagerakis, P. 2014. The tick tock of odontogenesis. Experimental Cell Research, 325(2): 83–9.CrossRefGoogle ScholarPubMed

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