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Chapter 29 - The physics and biology of magnetic resonance imaging: medical miracle anyone?

from Section V - Technical considerations and dosimetry

Published online by Cambridge University Press:  05 September 2015

Robert V. Mulkern
Affiliation:
Associate Physicist at the Department of Radiology, Boston Children’s Hospital and Associate Professor of Radiology at Harvard Medical School, Boston, Massachusetts, USA
Paul K. Kleinman
Affiliation:
Children's Hospital Boston
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Summary

In perhaps one of the greatest marriages ever conceived between two distinct and proudly independent scientific fields, physics and biology, magnetic resonance imaging (MRI) emerged to benefit humankind. Securely ensconced in the medical arena, MRI is a noninvasive diagnostic imaging tool with unique and unparalleled capabilities that daily generate anatomic and functional data for radiologic diagnosis and patient management decisions throughout the world. Indeed, after only some 30 years in use and development, a world without MRI seems inconceivable in the context of modern medical practice and scientific inquiry. As has been illustrated in preceding chapters, MRI has become integral to the assessment of abusive head and spinal trauma. Furthermore, with the use of spectroscopy, diffusion-weighted and perfusion imaging, it has begun to elucidate the complex cascade of events that occur following inflicted neurotrauma. It also plays an important role in the delineation of an array of abusive musculoskeletal injuries and it is occasionally applied to cases of thoracoabdominal trauma.

So, how does it work and why does it work so well? Herein I attempt to answer these questions by offering relatively nontechnical explanations of MRI that incorporate the essential physical and biologic elements responsible for this medical miracle. Since this textbook speaks to a diverse audience with variable interests and affinities for this complex subject, this chapter is as an introduction to the newcomer, and for the more experienced, a vehicle for deeper intuitive understanding of this challenging topic.

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Publisher: Cambridge University Press
Print publication year: 2015

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