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24 - Inherited Thrombophilia and Early Pregnancy

Published online by Cambridge University Press:  16 February 2017

Roy G. Farquharson
Affiliation:
Liverpool Women's Hospital
Mary D. Stephenson
Affiliation:
University of Illinois College of Medicine
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Early Pregnancy , pp. 234 - 246
Publisher: Cambridge University Press
Print publication year: 2017

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References

Coppens, M, Kaandorp, SP, Middeldorp, S. Inherited thrombophilias. Obstet Gynecol Clin North Am 2006; 33(3):357–74.CrossRefGoogle ScholarPubMed
Ray, JG, Shmorgun, D, Chan, WS. Common C677T polymorphism of the methylenetetrahydrofolate reductase gene and the risk of venous thromboembolism: meta-analysis of 31 studies. Pathophysiol Haemost Thromb 2002; 32:5158.CrossRefGoogle ScholarPubMed
Den Heijer, M, Willems, HPJ, Blom, HJ, Gerrits, WBJ, Cattaneo, M, Eichinger, S, et al. Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: a randomized, placebo-controlled, double-blind trial. Blood 2007; 109(1):139–44.CrossRefGoogle Scholar
Grandone, E, Tiscia, G, Colaizzo, D, Chinni, E, Pisanelli, D, Bafunno, V, et al. Role of the M2 haplotype within the annexin A5 gene in the occurrence of pregnancy-related venous thromboembolism. Am J Obstet Gynecol 2010; 203(5):461.e15.CrossRefGoogle ScholarPubMed
Bates, SM, Greer, IA, Middeldorp, S, Veenstra, DL, Prabulos, A-M, Vandvik, PO. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141(2 Suppl):e691S736.CrossRefGoogle ScholarPubMed
Ray, JG, Chan, WS. Deep vein thrombosis during pregnancy and the puerperium: a meta-analysis of the period of risk and the leg of presentation. Obstet Gynecol Surv 1999; 54:265–71.Google ScholarPubMed
O'Riordan, MN, Higgins, JR. Haemostasis in normal and abnormal pregnancy. Best Pract Res Clin Obstet Gynaecol 2003; 17(3):385–96.CrossRefGoogle ScholarPubMed
Dahm, AE, Tiscia, G, Holmgren, A, Jacobsen, AF, Skretting, G, Grandone, E, et al. Genetic variations in the annexin A5 gene and the risk of pregnancy related venous thrombosis. J Thromb Haemost 2015;13 (3):409–13.CrossRefGoogle ScholarPubMed
Jacobsen A, F, Skjeldestad, FE, Sandset, PM. Ante- and postnatal risk factors of venous thrombosis: a hospital-based case-control study. J Thromb Haemost 2008; 6(6):905–12.CrossRefGoogle ScholarPubMed
Morris, JM, Algert, CS, Roberts, CL. Incidence and risk factors for pulmonary embolism in the postpartum period. J Thromb Haemost 2010; 8:9981003.CrossRefGoogle ScholarPubMed
Sultan, AA, Tata, LJ, West, J, Fiaschi, L, Fleming, KM, Nelson-Piercy, C, et al. Risk factors for first venous thromboembolism around pregnancy: a population-based cohort study from the United Kingdom. Blood 2013; 121(19):3953–61.CrossRefGoogle ScholarPubMed
Blondon, M, Quon, BS, Harrington, LB, Bounameaux, H, Smith, NL. Association between newborn birthweight and the risk of postpartum maternal venous thromboembolism: a population-based case-control study. Circulation 2015;131 (17):1471–76.CrossRefGoogle ScholarPubMed
Rodger, M. Pregnancy and venous thromboembolism: “TIPPS” Risk Strat. 2014; 2:387–92.Google Scholar
Pabinger, I, Grafenhofer, H, Kaider, A, Kyrle, PA, Quehenberger, P, Mannhalter, C, et al. Risk of pregnancy-associated recurrent venous thromboembolism in women with a history of venous thrombosis. J Thromb Haemost 2005; 3:949–54.CrossRefGoogle ScholarPubMed
Greer, IA, Nelson-Piercy, C. Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy. Blood 2005;106 (2):401–07.CrossRefGoogle ScholarPubMed
Bank, I, Libourel, EJ, Middeldorp, S, Van Der Meer, J, Büller, HR. High rate of skin complications due to low-molecular-weight heparins in pregnant women. J Thromb Haemost 2003;1:859–61.CrossRefGoogle ScholarPubMed
Sheldon, WR, Blum, J, Vogel, JP, Souza, JP, Gülmezoglu a, M, Winikoff, B, et al. Postpartum haemorrhage management, risks, and maternal outcomes: findings from the World Health Organization Multicountry Survey on Maternal and Newborn Health. BJOG 2014; 121 (Suppl 1):513.CrossRefGoogle ScholarPubMed
Carroli, G, Cuesta, C, Abalos, E, Gulmezoglu a, M. Epidemiology of postpartum haemorrhage: a systematic review. Best Pract Res Clin Obstet Gynaecol 2008; 22(6):9991012.CrossRefGoogle ScholarPubMed
Sanson, B, Lensing, AWA, Prins, MH, Ginsberg, JS, Barkagan, ZS, Lavenne-pardonge, E, et al. Safety of low-molecular-weight heparin in pregnancy: a systematic review. Thromb Hemost 1999; 8(15):668–72.Google Scholar
Lepercq, J, Conard, J, Borel-Derlon, A, Darmon, JY, Boudignat, O, Francoual, C, et al. Venous thromboembolism during pregnancy: a retrospective study of enoxaparin safety in 624 pregnancies. Br J Obstet Gynaecol 2001; 108:1134–40.Google ScholarPubMed
American College of Obstetricians and Gynecologists Women's Health Care Physicians. ACOG Practice Bulletin No. 138: Inherited thrombophilias in pregnancy. Obstet Gynecol 2013; 122(3):706–17.Google Scholar
Visser, J, Ulander, V-M, Helmerhorst, FM, Lampinen, K, Morin-Papunen, L, Bloemenkamp, KWM, et al. Thromboprophylaxis for recurrent miscarriage in women with or without thrombophilia. HABENOX: a randomised multicentre trial. Thromb Haemost 2011; 105(2):295301.CrossRefGoogle ScholarPubMed
Bleker, SM, Coppens, M, Middeldorp, S. Sex, thrombosis and inherited thrombophilia. Blood Rev 2014; 28(3):123–33.CrossRefGoogle ScholarPubMed
Cannegieter, SC, van Hylckama, Vlieg A. Venous thrombosis: understanding the paradoxes of recurrence. J Thromb Haemost 2013; 11 (Suppl 1):161–69.CrossRefGoogle ScholarPubMed
Middeldorp, S, van Hylckama Vlieg, A. Does thrombophilia testing help in the clinical management of patients? Br J Haematol 2008; 143(3):321–35.CrossRefGoogle ScholarPubMed
Chan, WS, Anand, S, Ginsberg, JS. Anticoagulation of pregnant women with mechanical heart valves: a systematic review of the literature. Arch Intern Med 2000; 160:191–96.CrossRefGoogle Scholar
Middeldorp, S. How I treat pregnancy-related venous thromboembolism. Blood 2011; 118(20):5394–400.CrossRefGoogle Scholar
Preston, F, Rosendaal, F, Walker, I, Briët, E, Berntorp, E, Conard, J, et al. Increased fetal loss in women with heritable thrombophilia. Lancet 1996; 348(9032):913–16.CrossRefGoogle ScholarPubMed
Rey, E, Kahn, SR, David, M, Shrier, I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003; 361(9361):901–08.CrossRefGoogle ScholarPubMed
Robertson, L, Wu, O, Langhorne, P, Twaddle, S, Clark, P, Lowe, GDO, et al. Thrombophilia in pregnancy: a systematic review. Br J Haematol 2006; 132(2):171–96.CrossRefGoogle ScholarPubMed
Rodger, MA, Walker, MC, Smith, GN, Wells, PS, Ramsay, T, Langlois, NJ, et al. Is thrombophilia associated with placenta-mediated pregnancy complications? A prospective cohort study. J Thromb Haemost 2014; 12(4):469–78.Google ScholarPubMed
Rai, R, Regan, L. Recurrent miscarriage. Lancet 2006; 368(9535):601–11.CrossRefGoogle ScholarPubMed
Kujovich, JL. Thrombophilia and pregnancy complications. Am J Obstet Gynecol 2004; 191(2):412–24.CrossRefGoogle ScholarPubMed
Bennett, SA, Bagot, CN, Arya, R. Pregnancy loss and thrombophilia: the elusive link. Br J Haematol 2012; 157(5):529–42.CrossRefGoogle ScholarPubMed
Isermann, B, Sood, R, Pawlinski, R, Zogg, M, Kalloway, S, Degen, JL, et al. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med 2003; 9(3):331–37.CrossRefGoogle ScholarPubMed
Lay, AJ, Liang, Z, Rosen, ED, Castellino, FJ. Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. J Clin Invest 2005; 115(6):1552–61.CrossRefGoogle ScholarPubMed
Sood, R, Zogg, M, Westrick, RJ, Guo, Y-H, Kerschen, EJ, Girardi, G, et al. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers. J Exp Med 2007; 204(5):1049–56.CrossRefGoogle ScholarPubMed
Bose, P, Black, S, Kadyrov, M, Weissenborn, U, Neulen, J, Regan, L, et al. Heparin and aspirin attenuate placental apoptosis in vitro: implications for early pregnancy failure. Am J Obstet Gynecol 2005; 192(1):2330.CrossRefGoogle ScholarPubMed
Luley, L, Schumacher, A, Mulla, MJ, Franke, D, Löttge, M, Fill Malfertheiner, S, et al. Low molecular weight heparin modulates maternal immune response in pregnant women and mice with thrombophilia. Am J Reprod Immunol 2015; 73(5):417–27.CrossRefGoogle ScholarPubMed
Tüttelmann, F, Ivanov, P, Dietzel, C, Sofroniou, A, Tsvyatkovska, TM, Komsa-Penkova, RS, et al. Further insights into the role of the annexin A5 M2 haplotype as recurrent pregnancy loss factor, assessing timing of miscarriage and partner risk. Fertil Steril 2013; 100(5):1321–25.CrossRefGoogle ScholarPubMed
Bogdanova, N, Horst, J, Chlystun, M, Croucher, PJP, Nebel, A, Bohring, A, et al. A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss. Hum Mol Genet 2007; 16(5):573–78.CrossRefGoogle ScholarPubMed
Thean Hock, T, Bogdanova, N, Kai Cheen, A, Kathirgamanathan, S, bin Abdullah, R, Mohd Yusoff, N, et al. M2/ANXA5 haplotype as a predisposition factor in Malay women and couples experiencing recurrent spontaneous abortion: a pilot study. Reprod Biomed Online 2015; 30(4):434–39.CrossRefGoogle ScholarPubMed
Toth, B, Vocke, F, Rogenhofer, N, Friese, K, Thaler, CJ, Lohse, P. Paternal thrombophilic gene mutations are not associated with recurrent miscarriage. Am J Reprod Immunol 2008; 60(4):325–32.CrossRefGoogle Scholar
Udry, S, Aranda, FM, Latino, JO, de Larrañaga, GF. Paternal factor V Leiden and recurrent pregnancy loss: a new concept behind fetal genetics? J Thromb Haemost 2014; 12(5):666–69.Google Scholar
Kaandorp, SP, Goddijn, M, van der Post, J AM, Hutten, BA, Verhoeve, HR, Hamulyák, K, et al. Aspirin plus heparin or aspirin alone in women with recurrent miscarriage. N Engl J Med 2010; 362(17):1586–96.CrossRefGoogle ScholarPubMed
Clark, P, Walker, ID, Langhorne, P, Crichton, L, Thomson, A, Greaves, M, et al. A multicenter, randomized controlled trial of low-molecular-weight heparin and low-dose aspirin in women with recurrent miscarriage. Blood 2010; 115(21):4162–67.CrossRefGoogle ScholarPubMed
Pasquier, E, de Saint Martin, L, Bohec, C, Chauleur, C, Bretelle, F, Marhic, G, et al. Enoxaparin for prevention of unexplained recurrent miscarriage: a multicenter randomized double-blind placebo-controlled trial. Blood 2015;33(0):2200–05.Google Scholar
Brenner, B, Huffman, R, Carp, H, Dulitsky, M, Younis, J. Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: the LlVE-ENOX study. J Thromb Haemost 2005; 3(Table 1):227–29.CrossRefGoogle ScholarPubMed
Rodger, MA, Hague, WM, Kingdom, J, Kahn, SR, Karovitch, A, Sermer, M, et al. Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial. Lancet 2014; 6736(14):111.Google Scholar
Gris, JC, Mercier, E, Quéré, I, Lavigne-Lissalde, G, Cochery-Nouvellon, E, Hoffet, M, et al. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood 2004; 103:3695–99.CrossRefGoogle Scholar
Rodger, M, Gris, JC, Quére, I, Dauzat, M, Marès, P. Important publication missing key information [4](multiple letters). Blood 2014; 123(6):822–28.Google Scholar
Coppens, M, Folkeringa, N, Teune, MJ, Hamulyák, K, Van Der Meer, J, Prins, MH, et al. Outcome of the subsequent pregnancy after a first loss in women with the factor V Leiden or prothrombin 20210A mutations. J Thromb Haemost 2007; 5:1444–48.Google ScholarPubMed
De Jong, PG, Goddijn, M, Middeldorp, S. Antithrombotic therapy for pregnancy loss. Hum Reprod Update 2013; 19(6):656–73.CrossRefGoogle ScholarPubMed
Middeldorp, S. Thrombophilia and pregnancy complications: cause or association? J Thromb Haemost 2007; 5(Suppl 1):276–82.CrossRefGoogle ScholarPubMed
Azem, F. Increased rates of thrombophilia in women with repeated IVF failures. Hum Reprod 2004; 19(2):368–70.CrossRefGoogle ScholarPubMed
Di Nisio, M, Rutjes, AWS, Ferrante, N, Tiboni, GM, Cuccurullo, F, Porreca, E. Thrombophilia and outcomes of assisted reproduction technologies: a systematic review and meta-analysis. Blood 2011; 118(10):2670–78.CrossRefGoogle ScholarPubMed
Göpel, W. Factor-V- Leiden: relation to fertility? Lancet 2001; 358:1238–39.Google Scholar
Rudick, B, Su, HI, Sammel, MD, Kovalevsky, G, Shaunik, A, Barnhart, K. Is factor V Leiden mutation a cause of in vitro fertilization failure? Fertil Steril 2009; 92(4):1256–59.CrossRefGoogle ScholarPubMed
Kerlin, BA, Yan, SB, Isermann, BH, Brandt, JT, Sood, R, Basson, BR, et al. Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia. Blood 2003; 102(9):3085–92.CrossRefGoogle ScholarPubMed
Griffin, JH, Zlokovic, B V, Mosnier, LO. Protein C anticoagulant and cytoprotective pathways. Int J Hematol 2012; 95(4):333–45.CrossRefGoogle ScholarPubMed
Bellver, J, Soares, SR, Alvarez, C, Muñoz, E, Ramírez, A, Rubio, C, et al. The role of thrombophilia and thyroid autoimmunity in unexplained infertility, implantation failure and recurrent spontaneous abortion. Hum Reprod 2008; 23(2):278–84.CrossRefGoogle ScholarPubMed
Steinvil, A., Raz, R, Berliner, S, Steinberg, DM, Zeltser, D, Levran, D, et al. Association of common thrombophilias and antiphospholipid antibodies with success rate of in vitro fertilisation. Thromb Haemost 2012; 108(6):1192–97.Google ScholarPubMed
Van Mens, TE, Levi, M, Middeldorp, S. Evolution of Factor V Leiden. Thromb Haemost 2013; 110(1):2330.Google ScholarPubMed
Kaandorp, SP, van Mens, TE, Middeldorp, S, Hutten, BA, Hof, MHP, van der Post, JAM, et al. Time to conception and time to live birth in women with unexplained recurrent miscarriage. Hum Reprod 2014; 0(0):17.Google Scholar
Cohn, DM, Repping, S, Büller, HR, Meijers, JCM, Middeldorp, S. Increased sperm count may account for high population frequency of factor V Leiden. J Thromb Haemost 2010; 8(3):513–16.CrossRefGoogle ScholarPubMed
Fishel, S, Patel, R, Lytollis, A, Robinson, J, Smedley, M, Smith, P, et al. Multicentre study of the clinical relevance of screening IVF patients for carrier status of the annexin A5 M2 haplotype. Reprod Biomed Online 2014; 29(1):8087.CrossRefGoogle ScholarPubMed
Dentali, F, Grandone, E, Rezoagli, E, Ageno, W. Efficacy of low molecular weight heparin in patients undergoing in vitro fertilization or intracytoplasmic sperm injection. J Thromb Haemost 2011; 9(12):2503–06.CrossRefGoogle ScholarPubMed

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