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Lamotrigine

Published online by Cambridge University Press:  01 June 2018

Philip N. Patsalos  and
Erik K. St Louis
Philip N. Patsalos
Affiliation:
UCL Institute for Neurology
Erik K. St Louis
Affiliation:
Mayo Clinic
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The Epilepsy Prescriber's Guide to Antiepileptic Drugs , pp. 129 - 143
Publisher: Cambridge University Press
Print publication year: 2018

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References

Suggested Reading

Barr, PA, Buettiker, VE, Antony, JH. Efficacy of lamotrigine in refractory neonatal seizures. Pediatric Neurology 1999; 20: 161–163.Google Scholar
Barron, TF, Hunt, SL, Hoban, TF, Price, ML. Lamotrigine monotherapy in children. Pediatric Neurology 2000; 23: 160–163.Google Scholar
Baumann, RJ, Fakhoury, TA, Kustra, RP, Vuong, A, Hammer, AE, Messenheimer, JA. Conversion to lamotrigine monotherapy from valproate monotherapy in older adolescent patients with epilepsy. Current Medical Research Opinion 2007; 23: 2461–2465.CrossRefGoogle ScholarPubMed
Brodie, MJ, Richens, A, Yuen, AW. Double-blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. UK Lamotrigine/Carbamazepine Monotherapy Trial Group. Lancet 1995; 345: 476–479.Google Scholar
Brodie, MJ, Yuen, AW. Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 Study Group. Epilepsy Research 1997; 26: 423–432.CrossRefGoogle ScholarPubMed
Campbell, E, Kennedy, F, Russell, A, Smithson, WH, Parsons, L, Morrison, PJ, Liggan, B, Irwin, B, Delanty, N, Hunt, SJ, Craig, J, Morrow, J. Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. Journal of Neurology Neurosurgery and Psychiatry 2014; 85: 1029–1034.CrossRefGoogle ScholarPubMed
Cheung, YK, Cheng, SH, Chan, EJ, Lo, SV, Ng, MH, Kwan, P. HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese. Epilepsia 2013; 54: 1307–1314.CrossRefGoogle ScholarPubMed
Cunnington, MC, Weil, JG, Messenheimer, JA, Ferber, S, Yerby, M, Tennis, P. Final results from 18 years of the International Lamotrigine Pregnancy Registry. Neurology 2011; 76: 1817–1823.Google Scholar
Fitton, A, Goa, KL. Lamotrigine: an update of its pharmacology and therapeutic use in epilepsy. Drugs 1995; 50: 691–713.CrossRefGoogle ScholarPubMed
Frank, LM, Enlow, T, Holmes, GL, Manesco, P, Concannon, S, Chen, C, Womble, G, Casale, EJ. Lamictal (lamotrigine) monotherapy for typical absence seizures in children. Epilepsia 1999; 40: 973–979.Google Scholar
French, JA, Kanner, AM, Bautista, J, et al. Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004; 62: 1252–1260.Google Scholar
French, JA, Kanner, AM, Bautista, J, et al. Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology 2004; 62: 1261–1273.Google Scholar
Gamble, C, Williamson, PR, Chadwick, DW, Marson, AG. A meta-analysis of individual patient responses to lamotrigine or carbamazepine monotherapy. Neurology 2006; 66: 1310–1317.CrossRefGoogle ScholarPubMed
Gidal, BE, Sheth, R, Parnell, J, Maloney, K, Sale, M. Evaluation of VPA dose and concentration effects on lamotrigine pharmacokinetics: implications for conversion to lamotrigine monotherapy. Epilepsy Research 2003; 57: 85–93.CrossRefGoogle ScholarPubMed
Glauser, TA, Cnaan, A, Shinnar, S, Hirtz, DG, Dlugos, D, Masur, D, Clark, PO, Capparelli, EV, Adamson, PC. for the Childhood Absence Epilepsy Study Group. Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy. New England Journal of Medicine 2010; 362: 790–799.Google Scholar
Guberman, AH, Besag, FM, Brodie, MJ, Dooley, JM, Duchowny, MS, Pellock, JM, Richens, A, Stern, RS, Trevathan, E. Lamotrigine-associated rash: risk/benefit considerations in adults and children. Epilepsia 1999; 40: 985–991.CrossRefGoogle ScholarPubMed
Hernandez-Diaz, S, Smith, CR, Shen, A, Mittendorf, R, Hauser, WA, Yerby, M, Holmes, LB. Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012; 78: 1692–1699.CrossRefGoogle ScholarPubMed
Johannessen Landmark, C, Patsalos, PN. Drug interactions involving the new second- and third-generation antiepileptic drugs. Expert Reviews in Neurotherapeutics 2010; 10: 119–140.CrossRefGoogle ScholarPubMed
Kanner, AM, Frey, M. Adding valproate to lamotrigine: a study of their pharmacokinetic interaction. Neurology 2000; 55: 588–591.CrossRefGoogle ScholarPubMed
Marson, AG, Al-Kharusi, AM, Alwaid, M, et al. SANAD Study Group. The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomized controlled trial. Lancet 2007; 369: 1000–1015.CrossRefGoogle ScholarPubMed
Patsalos, PN. Antiepileptic drug interactions: a clinical guide, 3rd edition. Springer, London, UK; 2016.CrossRefGoogle Scholar
Patsalos, PN, Berry, DJ, Bourgeois, BFD, Cloyd, JC, Glauser, TA, Johannessen, SI, Leppik, IE, Tomson, T, Perucca, E. Antiepileptic drugs – best practice guidelines for therapeutic drug monitoring: a position paper by the Subcommission on Therapeutic Drug Monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia 2008; 49: 1239–1276.CrossRefGoogle ScholarPubMed
Patsalos, PN, Berry, DJ. Therapeutic drug monitoring of antiepileptic drugs by use of saliva. Therapeutic Drug Monitoring 2013; 35: 4–29.CrossRefGoogle ScholarPubMed
Pennell, PB, Newport, DJ, Stowe, ZN, Helmers, SL, Montgomery, JQ, Henry, TR. The impact of pregnancy and childbirth on the metabolism of lamotrigine. Neurology 2004; 62: 292–295.CrossRefGoogle Scholar
Sabers, A, Ohman, I, Christensen, J, Tomson, T. Oral contraceptives reduce lamotrigine plasma levels. Neurology 2003; 61: 570–571.CrossRefGoogle ScholarPubMed
Simms, KM, Kortepeter, C, Avigan, M. Lamotrigine and aseptic meningitis. Neurology 2012; 78: 921–927.CrossRefGoogle ScholarPubMed
St. Louis, EK. The art of managing conversions between antiepileptic drugs; maximizing patient tolerability and quality of life. Pharmaceuticals 2010; 3: 2956–2969.CrossRefGoogle ScholarPubMed
St. Louis, EK, Gidal, BE, Henry, TR, Kaydanova, Y, Krumholz, A, McCabe, PH, Montouris, GD, Rosenfeld, WE, Smith, BJ, Stern, JM, Waterhouse, EJ, Schulz, RM, Garnett, WR, Bramley, T. Conversions between monotherapies in epilepsy: expert consensus. Epilepsy and Behavior 2007; 11: 222–2234.Google Scholar
Tomson, T, Luef, G, Sabers, A, Pittschieler, S, Ohman, I. Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives. Neurology 2006; 67: 1297–1299.CrossRefGoogle ScholarPubMed
Zupanc, ML. Antiepileptic drugs and hormonal contraceptives in adolescent women with epilepsy. Neurology 2006; 66(Suppl 3): S37–S45.CrossRefGoogle ScholarPubMed

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