So much for prophesy. What the great German philosopher confidently declared to be “absurd” transpired less than a hundred years later. Darwin was precisely the “Newton of a blade of grass” that Kant predicted would never appear. The Origin of Species was the beginning of something big; but, as we have seen, it was far from the last word. In The End of Science: Facing the Limits of Knowledge in the Twilight of the Scientific Age (1996), the science writer John Horgan argues that evolutionary biology has effectively come to an end, not because it has failed miserably, but rather because it has succeeded so brilliantly. It has already solved all the major problems, and there's nothing left to do but simply tie up a few loose ends. Unlikely. A theme running through this book is that although Darwinism has indeed succeeded brilliantly in unraveling some of the deepest mysteries of nature, many issues concerning natural selection, adaptation, and directionality remain to be sorted out. Evolutionary biology is as vigorous as ever. The next century should be interesting.