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Chapter 33 - The Artificial Ovary

from Section 9 - New Research and Technologies

Published online by Cambridge University Press:  27 March 2021

By
Maria Costanza Chiti  and
Christiani A Amorim
Edited by
Jacques Donnez  and
S. Samuel Kim
Jacques Donnez
Affiliation:
Catholic University of Louvain, Brussels
S. Samuel Kim
Affiliation:
University of Kansas School of Medicine
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Summary

Since the first publications on the artificial ovary, many advances have been made. At that time, no studies had yet proved the feasibility of the concept, so it might have appeared provocative to unable to propose this option as a future fertility restoration approach for women unable to undergo ovarian tissue transplantation. Today, different artificial ovary prototypes demonstrate that this technique is able to restore both endocrine and reproductive functions in a murine model, producing healthy pups. However, with a view to future clinical application, further studies with human ovarian tissue and human follicles are essential. The aim of this chapter is to highlight the latest developments and advances in the field, as well as future directions for prompt translation to a clinical setting.

Type
Chapter
Information
Fertility Preservation
Principles and Practice
 , pp. 381 - 393
Publisher: Cambridge University Press
Print publication year: 2021

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