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Chapter 15 - Drugs in Pregnancy and Teratogenesis

Published online by Cambridge University Press:  08 June 2023

Edited by
Zarko Alfirevic ,
Seshadri Suresh  and
Jonathan Hyett
Zarko Alfirevic
Affiliation:
Liverpool Women's Hospital
Seshadri Suresh
Affiliation:
Mediscan, Chennai
Jonathan Hyett
Affiliation:
Prince Alfred Hospital, Sydney
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Summary

This chapter starts with definitions of teratogens and susceptibility of a fetus to a teratogenic insult depending on the phases of the exposure. The basic principles of counselling regarding drug use in pregnancy are outlined. Risks of congenital malformations are presented in a tabular form for the following classes of drugs: antibiotics, anticoagulants, antidepressants, antipsychotics and mood stabilisers, antiepileptics, antihypertensives, autoimmune disease drugs, chemotherapy agents, abortifacients, vitamins.

Possible teratogenic effects of substance misuse and ionising radiation are also included.

Type
Chapter
Information
Fetal Medicine
An Illustrated Textbook
 , pp. 381 - 398
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Reading

Australian Government, Department of Health, Therapeutic Goods Administration: www.tga.gov.auGoogle Scholar
FDA categories and summaries: www.drugs.comGoogle Scholar
Kumar, R, De Jesus, O. Radiation effects on the fetus. 2021. www.ncbi.nlm.nih.gov/books/NBK564358Google Scholar
RCOG. Green-Top Guideline No. 68: Epilepsy in Pregnancy. 2016. www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/epilepsy-in-pregnancy-green-top-guideline-no-68.Google Scholar
UK Teratology Information Service: www.uktis.orgGoogle Scholar

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