Book contents
- Fetal Therapy
- Fetal Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Foreword
- Section 1: General Principles
- Section 2: Fetal Disease: Pathogenesis and Treatment
- Red Cell Alloimmunization
- Structural Heart Disease in the Fetus
- Fetal Dysrhythmias
- Manipulation of Fetal Amniotic Fluid Volume
- Fetal Infections
- Fetal Growth and Well-being
- Chapter 23 Fetal Growth Restriction: Placental Basis and Implications for Clinical Practice
- Chapter 24 Fetal Growth Restriction: Diagnosis and Management
- Chapter 25 Screening and Intervention for Fetal Growth Restriction
- Chapter 26 Maternal and Fetal Therapy: Can We Optimize Fetal Growth?
- Preterm Birth of the Singleton and Multiple Pregnancy
- Complications of Monochorionic Multiple Pregnancy: Twin-to-Twin Transfusion Syndrome
- Complications of Monochorionic Multiple Pregnancy: Fetal Growth Restriction in Monochorionic Twins
- Complications of Monochorionic Multiple Pregnancy: Twin Reversed Arterial Perfusion Sequence
- Complications of Monochorionic Multiple Pregnancy: Multifetal Reduction in Multiple Pregnancy
- Fetal Urinary Tract Obstruction
- Pleural Effusion and Pulmonary Pathology
- Surgical Correction of Neural Tube Anomalies
- Fetal Tumors
- Congenital Diaphragmatic Hernia
- Fetal Stem Cell Transplantation
- Gene Therapy
- Section III: The Future
- Index
- References
Chapter 24 - Fetal Growth Restriction: Diagnosis and Management
from Fetal Growth and Well-being
Published online by Cambridge University Press: 21 October 2019
- Fetal Therapy
- Fetal Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Foreword
- Section 1: General Principles
- Section 2: Fetal Disease: Pathogenesis and Treatment
- Red Cell Alloimmunization
- Structural Heart Disease in the Fetus
- Fetal Dysrhythmias
- Manipulation of Fetal Amniotic Fluid Volume
- Fetal Infections
- Fetal Growth and Well-being
- Chapter 23 Fetal Growth Restriction: Placental Basis and Implications for Clinical Practice
- Chapter 24 Fetal Growth Restriction: Diagnosis and Management
- Chapter 25 Screening and Intervention for Fetal Growth Restriction
- Chapter 26 Maternal and Fetal Therapy: Can We Optimize Fetal Growth?
- Preterm Birth of the Singleton and Multiple Pregnancy
- Complications of Monochorionic Multiple Pregnancy: Twin-to-Twin Transfusion Syndrome
- Complications of Monochorionic Multiple Pregnancy: Fetal Growth Restriction in Monochorionic Twins
- Complications of Monochorionic Multiple Pregnancy: Twin Reversed Arterial Perfusion Sequence
- Complications of Monochorionic Multiple Pregnancy: Multifetal Reduction in Multiple Pregnancy
- Fetal Urinary Tract Obstruction
- Pleural Effusion and Pulmonary Pathology
- Surgical Correction of Neural Tube Anomalies
- Fetal Tumors
- Congenital Diaphragmatic Hernia
- Fetal Stem Cell Transplantation
- Gene Therapy
- Section III: The Future
- Index
- References
Summary
Fetal growth restriction (FGR) is defined as failure of the fetus to achieve its genetically determined growth potential due to an underlying pathological process [1]. FGR affects approximately 10% of all pregnancies and is a major determinant of perinatal and childhood mortality and morbidity, as well as chronic disease in adulthood [2–4]. A challenge in studying FGR is the lack of a gold standard definition and clear diagnostic criteria. Small for gestational age (SGA) is often used interchangeably with FGR but fails to differentiate between the constitutionally small but healthy fetus and the pathologically growth-restricted fetus. SGA is typically defined as a baby <10th centile, but 40% of these babies are physiologically small and healthy, therefore fetal size alone cannot be used to differentiate SGA from FGR. Assessment of functional parameters has been proposed to improve diagnostic accuracy but may still miss the larger baby (>10th centile) that is also in fact growth restricted. The importance of accurately diagnosing FGR is that it identifies the potential risk of fetal demise or perinatal complications, which may be averted via appropriate monitoring and optimized delivery.
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- Information
- Fetal TherapyScientific Basis and Critical Appraisal of Clinical Benefits, pp. 264 - 278Publisher: Cambridge University PressPrint publication year: 2020