Book contents
- Fetal Therapy
- Fetal Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Foreword
- Section 1: General Principles
- Section 2: Fetal Disease: Pathogenesis and Treatment
- Red Cell Alloimmunization
- Structural Heart Disease in the Fetus
- Fetal Dysrhythmias
- Manipulation of Fetal Amniotic Fluid Volume
- Fetal Infections
- Fetal Growth and Well-being
- Preterm Birth of the Singleton and Multiple Pregnancy
- Chapter 27 The Pathogenesis of Preterm Birth: A Guide to Potential Therapeutic Targets
- Chapter 28 Clinical Interventions for the Prevention and Management of Spontaneous Preterm Birth in the Singleton Fetus
- Chapter 29 Clinical Interventions to Prevent Preterm Birth in Multiple Pregnancies
- Chapter 30 Reducing Neurologic Morbidity from Preterm Birth through Administering Therapy Prior to Delivery
- Complications of Monochorionic Multiple Pregnancy: Twin-to-Twin Transfusion Syndrome
- Complications of Monochorionic Multiple Pregnancy: Fetal Growth Restriction in Monochorionic Twins
- Complications of Monochorionic Multiple Pregnancy: Twin Reversed Arterial Perfusion Sequence
- Complications of Monochorionic Multiple Pregnancy: Multifetal Reduction in Multiple Pregnancy
- Fetal Urinary Tract Obstruction
- Pleural Effusion and Pulmonary Pathology
- Surgical Correction of Neural Tube Anomalies
- Fetal Tumors
- Congenital Diaphragmatic Hernia
- Fetal Stem Cell Transplantation
- Gene Therapy
- Section III: The Future
- Index
- References
Chapter 30 - Reducing Neurologic Morbidity from Preterm Birth through Administering Therapy Prior to Delivery
from Preterm Birth of the Singleton and Multiple Pregnancy
Published online by Cambridge University Press: 21 October 2019
- Fetal Therapy
- Fetal Therapy
- Copyright page
- Dedication
- Contents
- Contributors
- Foreword
- Section 1: General Principles
- Section 2: Fetal Disease: Pathogenesis and Treatment
- Red Cell Alloimmunization
- Structural Heart Disease in the Fetus
- Fetal Dysrhythmias
- Manipulation of Fetal Amniotic Fluid Volume
- Fetal Infections
- Fetal Growth and Well-being
- Preterm Birth of the Singleton and Multiple Pregnancy
- Chapter 27 The Pathogenesis of Preterm Birth: A Guide to Potential Therapeutic Targets
- Chapter 28 Clinical Interventions for the Prevention and Management of Spontaneous Preterm Birth in the Singleton Fetus
- Chapter 29 Clinical Interventions to Prevent Preterm Birth in Multiple Pregnancies
- Chapter 30 Reducing Neurologic Morbidity from Preterm Birth through Administering Therapy Prior to Delivery
- Complications of Monochorionic Multiple Pregnancy: Twin-to-Twin Transfusion Syndrome
- Complications of Monochorionic Multiple Pregnancy: Fetal Growth Restriction in Monochorionic Twins
- Complications of Monochorionic Multiple Pregnancy: Twin Reversed Arterial Perfusion Sequence
- Complications of Monochorionic Multiple Pregnancy: Multifetal Reduction in Multiple Pregnancy
- Fetal Urinary Tract Obstruction
- Pleural Effusion and Pulmonary Pathology
- Surgical Correction of Neural Tube Anomalies
- Fetal Tumors
- Congenital Diaphragmatic Hernia
- Fetal Stem Cell Transplantation
- Gene Therapy
- Section III: The Future
- Index
- References
Summary
Preterm birth before 37 weeks gestation affects 10–15% of all births, with nearly 15 million babies born preterm every year [1]. Prematurity is the leading cause of neonatal mortality, accounting for in excess of 75% of perinatal deaths [2]. Infants born preterm are at high risk of both short- and long-term neurological morbidity, including developmental delay, cognitive problems, hearing loss, visual impairment, behavioral problems, and cerebral palsy [3]. The impact of these sequelae is high, with 27.9% (IQR [interquartile range] 18.6–46.6) of preterm neonates suffering from at least one, and 8.1% (IQR 3.7–10.2) suffering multiple morbidities [3]. Despite improvements in perinatal care the incidence of preterm birth has changed little in decades. In contrast, improvements in neonatal care mean nearly 90% of all babies born less than 28 weeks in high-income countries survive, including babies born as early as 23 weeks’ gestation [1]. Despite this improvement in survival, babies born at extreme preterm gestations are at the highest risk of neurological injury, with rates of cerebral palsy and severe disability in these survivors remaining static [4].
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- Chapter
- Information
- Fetal TherapyScientific Basis and Critical Appraisal of Clinical Benefits, pp. 333 - 343Publisher: Cambridge University PressPrint publication year: 2020