Falconer, MA, Serafetinides, EA, Corsellis JAN. Etiology and pathogenesis of temporal lobe epilepsy. Arch Neurol. 1964;10:233–48.Google Scholar

Meiners, LC, Witkamp, TD, de Kort, GA, et al. Relevance of temporal lobe white matter changes in hippocampal sclerosis. Magnetic resonance imaging and histology. Invest Radiol. 1999;34:38–45.Google Scholar

Kuzniecky, R, Bilir, E, Gilliam, F, et al. Quantitative MRI in temporal lobe epilepsy: evidence for fornix atrophy. Neurology. 1999;53:496–501.Google Scholar

Seidenberg, M, Kelly, KG, Parrish, J, et al. Ipsilateral and contralateral MRI volumetric abnormalities in chronic unilateral temporal lobe epilepsy and their clinical correlates. Epilepsia. 2005;46:420–30.CrossRefGoogle ScholarPubMed

Hermann, B, Seidenberg, M, Bell, B, et al. Extratemporal quantitative MR volumetrics and neuropsychological status in temporal lobe epilepsy. J Int Neuropsychol Soc. 2003;9:353–62.Google Scholar

McMillan, AB, Hermann, BP, Johnson, SC, et al. Voxel-based morphometry of unilateral temporal lobe epilepsy reveals abnormalities in cerebral white matter. NeuroImage. 2004;23:167–74.Google Scholar

Bernasconi, N, Duchesne, S, Janke, A, et al. Whole-brain voxel-based statistical analysis of gray matter and white matter in temporal lobe epilepsy. NeuroImage. 2004;23:717–23.CrossRefGoogle Scholar

Pell, GS, Briellmann, RS, Waites, AB, et al. Voxel-based relaxometry: a new approach for analysis of T2 relaxometry changes in epilepsy. NeuroImage. 2004;21:707–13.Google Scholar

Bernasconi, A, Bernasconi, N, Caramanos, Z, et al. T2 relaxometry can lateralize mesial temporal lobe epilepsy in patients with normal MRI. NeuroImage. 2000;12:739–46.Google Scholar

Townsend, TN, Bernasconi, N, Pike, GB, et al. Quantitative analysis of temporal lobe white matter T2 relaxation time in temporal lobe epilepsy. NeuroImage. 2004;23:318–24.Google Scholar

Concha, L. A macroscopic view of microstructure: using diffusion-weighted images to infer damage, repair, and plasticity of white matter. Neuroscience. 2014;276:14–28.CrossRefGoogle ScholarPubMed

Slinger, G, Sinke, MR, Braun, KP, et al. White matter abnormalities at a regional and voxel level in focal and generalized epilepsy: A systematic review and meta-analysis. NeuroImage Clin. 2016;12:902–9.Google Scholar

Concha, L, Livy, DJ, Beaulieu, C, et al. In vivo diffusion tensor imaging and histopathology of the fimbria-fornix in temporal lobe epilepsy. J Neurosci. 2010;30:996–1002.Google Scholar

Garbelli, R, Milesi, G, Medici, V, et al. Blurring in patients with temporal lobe epilepsy: clinical, high-field imaging and ultrastructural study. Brain. 2012;135:2337–49.Google Scholar

Ozdogmus, O, Cavdar, S, Ersoy, Y, et al. A preliminary study, using electron and light-microscopic methods, of axon numbers in the fornix in autopsies of patients with temporal lobe epilepsy. Anat Sci Int. 2009;84:2–6.Google Scholar

Stefanits, H, Czech, T, Pataraia, E, et al. Prominent oligodendroglial response in surgical specimens of patients with temporal lobe epilepsy. Clin Neuropathol. 2012;31:409–17.CrossRefGoogle ScholarPubMed

Thom, M, Holton, JL, D’Arrigo, C, et al. Microdysgenesis with abnormal cortical myelinated fibres in temporal lobe epilepsy: a histopathological study with calbindin D-28-K immunohistochemistry. Neuropathol Appl Neurobiol. 2000;26:251–7.Google Scholar

Behrens, TE, Johansen-Berg, H, Woolrich, MW, et al. Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat Neurosci. 2003;6:750–7.Google Scholar

Wakana, S, Caprihan, A, Panzenboeck, MM, et al. Reproducibility of quantitative tractography methods applied to cerebral white matter. NeuroImage. 2007;36:630–44.Google Scholar

Hagler, DJ Jr, Ahmadi, ME, Kuperman, J, et al. Automated white-matter tractography using a probabilistic diffusion tensor atlas: Application to temporal lobe epilepsy. Hum Brain Mapp. 2009;30:1535–47.Google Scholar

Dauguet, J, Peled, S, Berezovskii, V, et al. Comparison of fiber tracts derived from in-vivo DTI tractography with 3D histological neural tract tracer reconstruction on a macaque brain. NeuroImage. 2007;37:530–8.CrossRefGoogle ScholarPubMed

Smith, SM, Jenkinson, M, Johansen-Berg, H, et al. Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. NeuroImage. 2006;31:1487–505.Google Scholar

Thivard, L, Lehericy, S, Krainik, A, et al. Diffusion tensor imaging in medial temporal lobe epilepsy with hippocampal sclerosis. NeuroImage. 2005;28:682–90.Google Scholar

Concha, L, Beaulieu, C, Gross, DW. Bilateral limbic diffusion abnormalities in unilateral temporal lobe epilepsy. Ann Neurol. 2005;57:188–96.Google Scholar

Otte, WM, Dijkhuizen, RM, van Meer, MP, et al. Characterization of functional and structural integrity in experimental focal epilepsy: reduced network efficiency coincides with white matter changes. PLOS ONE. 2012;7:e39078.Google Scholar

Concha, L, Kim, H, Bernasconi, A, et al. Spatial patterns of water diffusion along white matter tracts in temporal lobe epilepsy. Neurology. 2012;79:455–62.CrossRefGoogle ScholarPubMed

Liu, M, Concha, L, Lebel, C, et al. Mesial temporal sclerosis is linked with more widespread white matter changes in temporal lobe epilepsy. NeuroImage Clin. 2012;1:99–105.Google Scholar

Pustina, D, Doucet, G, Sperling, M, et al. Increased microstructural white matter correlations in left, but not right, temporal lobe epilepsy. Hum Brain Mapp. 2015;36:85–98.Google Scholar

Keller, SS, Schoene-Bake, JC, Gerdes, JS, et al. Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury. PLOS ONE. 2012;7:e46791.CrossRefGoogle ScholarPubMed

Voets, NL, Beckmann, CF, Cole, DM, et al. Structural substrates for resting network disruption in temporal lobe epilepsy. Brain. 2012;135:2350–7.Google Scholar

Hutchinson, E, Pulsipher, D, Dabbs, K, et al. Children with new-onset epilepsy exhibit diffusion abnormalities in cerebral white matter in the absence of volumetric differences. Epilepsy Res. 2010;88:208–14.Google Scholar

Vaughan, DN, Raffelt, D, Curwood, E, et al. Tract-specific atrophy in focal epilepsy: Disease, genetics, or seizures? Ann Neurol. 2017;81:240–50.Google Scholar

Winston, GP, Stretton, J, Sidhu, MK, et al. Progressive white matter changes following anterior temporal lobe resection for epilepsy. NeuroImage Clin. 2014;4:190–200.Google Scholar

Liu, M, Gross, DW, Wheatley, BM, et al. The acute phase of Wallerian degeneration: longitudinal diffusion tensor imaging of the fornix following temporal lobe surgery. NeuroImage. 2013;74:128–39.Google Scholar

Concha, L, Gross, DW, Wheatley, BM, et al. Diffusion tensor imaging of time-dependent axonal and myelin degradation after corpus callosotomy in epilepsy patients. NeuroImage. 2006;32:1090–9.Google Scholar

Eriksson, SH, Rugg-Gunn, FJ, Symms, MR, et al. Diffusion tensor imaging in patients with epilepsy and malformations of cortical development. Brain. 2001;124:617–26.Google Scholar

Fonseca Vde, C, Yasuda, CL, Tedeschi, GG, et al. White matter abnormalities in patients with focal cortical dysplasia revealed by diffusion tensor imaging analysis in a voxelwise approach. Front Neurol. 2012;3:121.Google Scholar

Lee, SK, Kim, DI, Mori, S, et al. Diffusion tensor MRI visualizes decreased subcortical fiber connectivity in focal cortical dysplasia. NeuroImage. 2004;22:1826–9.CrossRefGoogle ScholarPubMed

Reveley, C, Seth, AK, Pierpaoli, C, et al. Superficial white matter fiber systems impede detection of long-range cortical connections in diffusion MR tractography. Proc Natl Acad Sci USA. 2015;112:E2820–8.Google Scholar

Liu, M, Bernhardt, BC, Hong, SJ, et al. The superficial white matter in temporal lobe epilepsy: a key link between structural and functional network disruptions. Brain. 2016;139:2431–40.Google Scholar

Hong, SJ, Bernhardt, BC, Caldairou, B, et al. Multimodal MRI profiling of focal cortical dysplasia type II. Neurology. 2017;88:734–42.Google Scholar

Hermann, B, Seidenberg, M, Lee, EJ, et al. Cognitive phenotypes in temporal lobe epilepsy. J Int Neuropsychol Soc. 2007;13:12–20.Google Scholar

Winston, GP, Stretton, J, Sidhu, MK, et al. Structural correlates of impaired working memory in hippocampal sclerosis. Epilepsia. 2013;54:1143–53.Google Scholar

McDonald, CR, Leyden, KM, Hagler, DJ, et al. White matter microstructure complements morphometry for predicting verbal memory in epilepsy. Cortex. 2014;58:139–50.Google Scholar

Yogarajah, M, Powell, HW, Parker, GJ, et al. Tractography of the parahippocampal gyrus and material specific memory impairment in unilateral temporal lobe epilepsy. NeuroImage. 2008;40:1755–64.Google Scholar

Riley, JD, Franklin, DL, Choi, V, et al. Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profiles. Epilepsia. 2010;51:536–45.Google Scholar

Ekmekci, B, Bulut, HT, Gumustas, F, et al. The relationship between white matter abnormalities and cognitive functions in new-onset juvenile myoclonic epilepsy. Epilepsy Behav. 2016;62:166–70.Google Scholar

McDonald, CR, Ahmadi, ME, Hagler, DJ, et al. Diffusion tensor imaging correlates of memory and language impairments in temporal lobe epilepsy. Neurology. 2008;71:1869–76.Google Scholar

Powell, HW, Parker, GJ, Alexander, DC, et al. Abnormalities of language networks in temporal lobe epilepsy. NeuroImage. 2007;36:209–21.Google Scholar

Takaya, S, Liu, H, Greve, DN, et al. Altered anterior-posterior connectivity through the arcuate fasciculus in temporal lobe epilepsy. Hum Brain Mapp. 2016;37:4425–38.Google Scholar

Powell, HW, Parker, GJ, Alexander, DC, et al. Imaging language pathways predicts postoperative naming deficits. J Neurol Neurosurg Psychiatry. 2008;79:327–30.Google Scholar

Ellmore, TM, Beauchamp, MS, Breier, JI, et al. Temporal lobe white matter asymmetry and language laterality in epilepsy patients. NeuroImage. 2010;49:2033–44.Google Scholar

Keller, SS, Glenn, GR, Weber, B, et al. Preoperative automated fibre quantification predicts postoperative seizure outcome in temporal lobe epilepsy. Brain. 2017;140:68–82.Google Scholar

Wu, EX, Cheung, MM. MR diffusion kurtosis imaging for neural tissue characterization. NMR Biomed. 2010;23:836–48.Google Scholar

Bonilha, L, Jensen, JH, Baker, N, et al. The brain connectome as a personalized biomarker of seizure outcomes after temporal lobectomy. Neurology. 2015;84:1846–53.Google Scholar

Glenn, GR, Jensen, JH, Helpern, JA, et al. Epilepsy-related cytoarchitectonic abnormalities along white matter pathways. J Neurol Neurosurg Psychiatry. 2016;87:930–6.Google Scholar

Lemkaddem, A, Daducci, A, Kunz, N, et al. Connectivity and tissue microstructural alterations in right and left temporal lobe epilepsy revealed by diffusion spectrum imaging. NeuroImage Clin. 2014;5:349–58.Google Scholar

Loi, RQ, Leyden, KM, Balachandra, A, et al. Restriction spectrum imaging reveals decreased neurite density in patients with temporal lobe epilepsy. Epilepsia. 2016;57:1897–906.Google Scholar

Raffelt, DA, Tournier, JD, Smith, RE, et al. Investigating white matter fibre density and morphology using fixel-based analysis. NeuroImage. 2017;144:58–73.Google Scholar

Zhang, H, Schneider, T, Wheeler-Kingshott, CA, et al. NODDI: practical in vivo neurite orientation dispersion and density imaging of the human brain. NeuroImage. 2012;61:1000–16.Google Scholar

Bernhardt, BC, Hong, S, Bernasconi, A, et al. Imaging structural and functional brain networks in temporal lobe epilepsy. Front Hum Neurosci. 2013;7:624.Google Scholar

Bonilha, L, Nesland, T, Martz, GU, et al. Medial temporal lobe epilepsy is associated with neuronal fibre loss and paradoxical increase in structural connectivity of limbic structures. J Neurol Neurosurg Psychiatry. 2012;83:903–9.Google Scholar

Gleichgerrcht, E, Kocher, M, Bonilha, L. Connectomics and graph theory analyses: novel insights into network abnormalities in epilepsy. Epilepsia. 2015;56:1660–8.Google Scholar

Munsell, BC, Wee, CY, Keller, SS, et al. Evaluation of machine learning algorithms for treatment outcome prediction in patients with epilepsy based on structural connectome data. NeuroImage. 2015;118:219–30.CrossRefGoogle ScholarPubMed

Misic, B, Betzel, RF, Nematzadeh, A, et al. Cooperative and competitive spreading dynamics on the human connectome. Neuron. 2015;86:1518–29.Google Scholar

Abdelnour, F, Mueller, S, Raj, A. Relating cortical atrophy in temporal lobe epilepsy with graph diffusion-based network models. PLOS Comput Biol. 2015;11:e1004564.Google Scholar

Besson, P, Bandt, SK, Proix, T, et al. Anatomic consistencies across epilepsies: a stereotactic-EEG informed high-resolution structural connectivity study. Brain. 2017;140:2639–52.Google Scholar

Hutchings, F, Han, CE, Keller, SS, et al. Predicting surgery targets in temporal lobe epilepsy through structural connectome based simulations. PLOS Comput Biol. 2015;11:e1004642.Google Scholar

Proix, T, Bartolomei, F, Guye, M, et al. Individual brain structure and modelling predict seizure propagation. Brain. 2017;140:641–54.Google Scholar

Vollmar, C, O’Muircheartaigh, J, Symms, MR, et al. Altered microstructural connectivity in juvenile myoclonic epilepsy: the missing link. Neurology. 2012;78:1555–9.Google Scholar

Zhang, Z, Liao, W, Chen, H, et al. Altered functional-structural coupling of large-scale brain networks in idiopathic generalized epilepsy. Brain. 2011;134:2912–28.Google Scholar

Hong, SJ, Bernhardt, BC, Gill, RS, et al. The spectrum of structural and functional network alterations in malformations of cortical development. Brain. 2017;140:2133–43.Google Scholar

Vaessen, MJ, Jansen, JF, Vlooswijk, MC, et al. White matter network abnormalities are associated with cognitive decline in chronic epilepsy. Cereb Cortex. 2012;22:2139–47.Google Scholar

Bernasconi, A. Connectome-based models of the epileptogenic network: a step towards epileptomics? Brain. 2017;140:2525–7.Google Scholar

Bernhardt, BC, Fadaie, F, Vos de Wael R, et al. Preferential susceptibility of limbic cortices to microstructural damage in temporal lobe epilepsy: a quantitative T1 mapping study. NeuroImage. 2017. doi:10.1016/j.neuroimage.2017.06.002.CrossRefGoogle Scholar