Liver Disease in Children

doi:10.1017/CBO9781139012102

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The fourth edition of this authoritative text covers every aspect of liver disease affecting infants, children and adolescents. As in the previous editions, it offers an integrative approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. All of the chapters are written by international experts and address the unique pathophysiology, manifestations and management of these disorders. This edition of the landmark text features extended coverage of viral hepatitis, metabolic liver disease, fatty liver disease and liver transplantation, including a new chapter on post-transplant care and outcomes. All of the chapters have been updated to reflect changing epidemiology and recent advances in molecular medicine and genomics. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.

Review of previous edition:‘The essential pediatric hepatology textbook.'

Source: New England Journal of Medicine

Review of previous edition:‘Well written and organized … builds on a strong scientific foundation and effectively bridges pathophysiologic principles with clinical practice, providing authoritative updated reviews on all topics relevant to the discipline. The textbook is the premier reference in the field and should be truly enjoyed by primary care practitioners, gastroenterologists, hepatologists, and anyone genuinely interested in the care of children with liver disease.'

Source: Journal of the American Medical Association

Review of previous edition:‘The text is accompanied by an excellent selection of color plates and is generally well illustrated throughout … the authors are to be congratulated for tapping the writing skills of some of the foremost experts in pediatric hepatology for the text.'

Source: Pediatric Gastroenterology

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Contents

Frontmatter
pp i-iv
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Contents
pp v-vi
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List of Contributors
pp vii-x
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Preface
pp xi-xii
- By Frederick J. Suchy, University of Colorado Medical Center, Ronald J. Sokol, University of Colorado Medical Center, William F. Balistreri, University of Cincinnati College of Medicine
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Section I - Pathophysiology of pediatric liver disease
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Chapter 1 - Liver development
pp 1-9
- By Yiwei Zong, Department of Strategic Management, China Resources, China, Joshua R. Friedman, Perelman School of Medicine at the University of Pennsylvania, Division of Gastroenterology, Hepatology, and Nutrition, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
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Chapter 2 - Functional development of the liver
pp 10-23
- By Frederick J. Suchy, University of Colorado Medical Center
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Chapter 3 - Mechanisms of bile formation and cholestasis
pp 24-31
- By Nikita A. Gupta, Emory University School of Medicine, and Pediatric Hepatologist, Children’s Healthcare of Atlanta, GA, USA, Saul J. Karpen, Emory University School of Medicine, Department of Pediatric Gastroenterology, Hepatology and Nutrition, Atlanta, GA, USA
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Chapter 4 - Acute liver failure in children
pp 32-50
- By Robert H. Squires, Pediatric Gastroenterology, Hepatology and Nutrition, Children’s Hospital of Pittsburgh of UPMC, and Professor of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA, Estella M. Alonso, Northwestern University, Chicago; Department of Gastroenterology, Hepatology and Nutrition, Children’s Memorial Hospital, Chicago, IL, USA
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Chapter 5 - Cirrhosis and chronic liver failure
pp 51-67
- By Evelyn K. Hsu, Division of Gastroenterology and Hepatology, Seattle Children’s Hospital, University of Washington School of Medicine, Seattle, WA, USA, Karen F. Murray, Gastroenterology and Hepatology, Seattle Children’s Hospital, University of Washington School of Medicine, Seattle, WA, USA
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Chapter 6 - Portal hypertension
pp 68-87
- By Benjamin L. Shneider, University of Pittsburgh, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
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Chapter 7 - Laboratory assessment of liver function and injury in children
pp 88-100
- By Vicky Lee Ng, University of Toronto; Liver Transplant Program, Division of Gastroenterology, Hepatology and Nutrition, SickKids Transplant Centre, Hospital for Sick Children, Toronto, Ontario, Canada
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Section II - Cholestatic liver disease
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Chapter 8 - Approach to the infant with cholestasis
pp 101-110
- By Amy Feldman, Department of Gastroenterology, Hepatology and Nutrition, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora, CO, USA, Frederick J. Suchy, University of Colorado Medical Center
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Chapter 9 - Medical and nutritional management of cholestasis in infants and children
pp 111-139
- By Andrew P. Feranchak, Department of Pediatrics, UT Southwestern Medical Center and Children’s Medical Center, Dallas, TX, USA, Frederick J. Suchy, University of Colorado Medical Center , Ronald J. Sokol, University of Colorado Medical Center
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Chapter 10 - Neonatal hepatitis and congenital infections
pp 140-154
- By Philip Rosenthal, Departments of Pediatrics and Surgery and the Liver Center, the University of California, San Francisco, CA, USA
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Chapter 11 - Biliary atresia and other disorders of the extrahepatic bile ducts
pp 155-176
- By William F. Balistreri, University of Cincinnati College of Medicine , Jorge A. Bezerra, Pediatric Liver Care Center; The William and Rebecca Balistreri Chair of Pediatric Hepatology, Division of Gastroenterology, Hepatology and Nutrition, University of Cincinnati College of Medicine and Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA, Frederick C. Ryckman, Pediatric Surgery Training Program, Pediatric Liver Care Center, Cincinnati Children’s Hospital, Cincinnati, OH, USA
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Chapter 12 - Neonatal jaundice and disorders of bilirubin metabolism
pp 177-198
- By Mark Bartlett, University of Minnesota, Minneapolis, MN, USA, Glenn R. Gourley, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
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Chapter 13 - Familial hepatocellular cholestasis
pp 199-215
- By Frederick J. Suchy, University of Colorado Medical Center , Shikha S. Sundaram, Section of Gastroenterology, Hepatology and Nutrition, Children’s Hospital Colorado and University of Colorado School of Medicine, Aurora, CO, USA, Benjamin L. Shneider, Pediatric Hepatology, University of Pittsburgh, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA
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Chapter 14 - Alagille syndrome
pp 216-233
- By Binita M. Kamath, Department of Paediatrics, University of Toronto; Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada, Nancy B. Spinner, Division of Genomic Diagnostics, and Evelyn Willing Bromley Chair of Pediatric Pathology, Department of Pathology Perelman School of Medicine at the University of Pennsylvania, Children’s Hospital of Pennsylvania, Pittsburgh, PA, USA, David A. Piccoli, Division of Gastroenterology, Hepatology and Nutrition, Fred and Suzanne Biesecker Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Children’s Hospital of Pennsylvania, Philadelphia, PA, USA
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Chapter 15 - Intestinal failure-associated liver disease
pp 234-246
- By Jason Soden, Department of Gastroenterology, Hepatology, and Nutrition, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora, CO, USA, Ronald J. Sokol, University of Colorado Medical Center
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Chapter 16 - Disease of the gallbladder in infancy, childhood, and adolescence
pp 247-264
- By Frank W. DiPaola, Pediatric Gastroenterology, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children’s Hospital Medial Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA, James E. Heubi, Clinical Translational Research Center, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA
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Section III - Hepatitis and immune disorders
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Chapter 17 - Hepatitis A and hepatitis E virus infection
pp 265-275
- By Philip Rosenthal, Pediatric Hepatology Director Pediatric Clinical Research, Departments of Pediatrics and Surgery and the Liver Center, the University of California, San Francisco, CA, USA
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Chapter 18 - Hepatitis B virus infection
pp 276-294
- By Mei-Hwei Chang, Department of Pediatrics and Hepatitis Research Center, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan
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Chapter 19 - Hepatitis C virus infection
pp 295-310
- By Maureen M. Jonas, Division of Gastroenterology, Hepatology and Nutrition, Children’s Hospital Boston, and Harvard Medical School, Boston, MA, USA
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Chapter 20 - Autoimmune hepatitis
pp 311-321
- By Nanda Kerkar, Division of Gastroenterology, Hepatology and Nutrition, Pediatric Liver Disease/Liver Transplant Program, Mount Sinai School of Medicine, New York, NY, USA, Cara L. Mack, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Children’s Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA
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Chapter 21 - Sclerosing cholangitis
pp 322-340
- By Alexander G. Miethke, Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Cincinnati College of Medicine, and Pediatric Liver Care Center, Children’s Hospital Medical Center, Cincinnati, OH, USA, William F. Balistreri, University of Cincinnati College of Medicine
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Chapter 22 - Drug-induced liver disease
pp 341-369
- By Eve A. Roberts, Departments of Medicine, Paediatrics and Gastroenterology, University of Toronto, and Hepatologist, Division of Gastroenterology and Nutrition, Hospital for Sick Children, Toronto, Ontario, Canada
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Chapter 23 - Liver disease in immunodeficiencies
pp 370-386
- By Nedim Hadžić, King’s College Medical School, London, UK
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