The Thriving with Social Purpose (TSP) motivational pattern focuses on the powerful consequences of effectively “amplifying” each of the components within our motivational systems to promote optimal functioning, while also infusing goals focused on belonging, helping, equity, and social responsibility into our “home page” motivational orientation. This chapter thus explains, in scientific terms, what it means to thrive and how social purpose goals can elevate our life experience. Consistent with the idea that humans are “whole-person-in-context” living systems, this chapter also discusses ways to enhance motivation and optimal functioning by amplifying the nonmotivational components of human functioning (i.e., biology, knowledge and skills, and key features of the environment). This is the chapter that scholars can best use to generate a wide range of hypotheses for future research about motivation and optimal functioning and that professionals can best use to guide and catalyze their (intrinsically whole-person) intervention efforts.