Towards the end of May 1498 Vasco da Gama hove to off Calicut having successfully confirmed in the most practical way possible that a sea route existed between Europe and the Indian sub-continent. The immediate objective was King Manuel I of Portugal (1495–1521) hoping to gain direct entry into the profitable spice trade that had previously been monopolised by Venetian merchants using the land route that connected the Mediterranean with the Red Sea. However Manuel I had a further object and one that extended beyond simple trade. He wished, with the support of the papacy, to eliminate the extensive influence of Muslims in the Indian Ocean, especially the trade networks established by Arab merchants with the port towns of India’s Malabar Coast. One of the most fervent of all Catholic countries, the rulers of Portugal were determined to bring about a total subjugation of Islam and to this end were already embroiled in a vicious war against Moorish forces in Morocco. Indeed, the decision to search out a sea route to India was nothing less than an extension of the earlier medieval crusades, allowing Portugal to strike a blow at both the Ottoman Empire and the Mamluk state of Egypt. Since the fall of Constantinople in 1453 the onward transshipment into Europe of spices traded on the Malabar Coast had to pass through these Muslim territories, bringing to both great financial benefit and helping ensure that they could maintain a continuing high level of expenditure on their military forces. That the Ottoman Turks were even, at that time, threatening to take the Holy City of Rome merely added to the urgency of the situation, pushing the Portuguese into the Indian Ocean to search out others who might embrace Christendom and join with them in this Holy Crusade.