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Chapter 13 - Acquired Thrombocytopenias

from Section IV - Platelet Disorders

Published online by Cambridge University Press:  30 January 2021

By
Patricia E. Davenport  and
Martha C. Sola-Visner
Edited by
Pedro A. de Alarcón ,
Eric J. Werner ,
Robert D. Christensen  and
Martha C. Sola-Visner
Pedro A. de Alarcón
Affiliation:
University of Illinois College of Medicine
Eric J. Werner
Affiliation:
Children's Hospital of the King's Daughters
Robert D. Christensen
Affiliation:
University of Utah
Martha C. Sola-Visner
Affiliation:
Harvard University, Massachusetts
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Summary

In this chapter, we will focus exclusively on acquired thrombocytopenias that present in the neonatal period. We will discuss the mechanisms underlying some of the most common varieties of neonatal thrombocytopenia, and how the biological differences between neonatal and adult megakaryocytes might contribute to the susceptibility of neonates to develop thrombocytopenia. We will then review the presentation, pathophysiology, and management of the most common etiologies of neonatal early- and late-onset thrombocytopenia, including autoimmune neonatal thrombocytopenia. Alloimmune and congenital causes of neonatal thrombocytopenia will be discussed in detail in Chapters 14 and 15, respectively.

Type
Chapter
Information
Neonatal Hematology
Pathogenesis, Diagnosis, and Management of Hematologic Problems
 , pp. 210 - 222
Publisher: Cambridge University Press
Print publication year: 2021

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