Contents

pp v-vi

List of contributors

pp vii-viii

Foreword

pp ix-x

Section 1 - Scientific background

1 - Neurological outcome after perinatal asphyxia at term

pp 1-15

2 - Molecular mechanisms of neonatal brain injury and neural rescue

pp 16-32

3 - The discovery of hypothermic neural rescue therapy for perinatal hypoxic–ischaemic encephalopathy

pp 33-39

4 - Clinical trials of hypothermic neural rescue

pp 40-52

5 - Economic evaluation of hypothermic neural rescue

pp 53-64

Section 2 - Clinical neural rescue

6 - Challenges for parents and clinicians discussing neuroprotective treatments

pp 65-72

7 - The pharmacology of hypothermia

pp 73-84

8 - Selection of infants for hypothermic neural rescue

pp 85-94

9 - Hypothermia during patient transport

pp 95-106

10 - Whole body cooling for therapeutic hypothermia

pp 107-118

11 - Selective head cooling

pp 119-127

12 - Hypothermic neural rescue for neonatal encephalopathy in mid- and low-resource settings

pp 128-141

13 - Cerebral function monitoring and EEG

pp 142-152

14 - Magnetic resonance imaging in hypoxic–ischaemic encephalopathy and the effects of hypothermia

pp 153-165

15 - Novel uses of hypothermia

pp 166-171

16 - Neurological follow-up of infants treated with hypothermia

pp 172-181

17 - Registry surveillance after neuroprotective treatment

pp 182-194

Section 3 - The future

18 - Novel neuroprotective therapies

pp 195-207

19 - Combining hypothermia with other therapies for neonatal neuroprotection

pp 208-218

20 - Biomarkers for studies of neuroprotection in infants with hypoxic–ischaemic encephalopathy

pp 219-228

Index

pp 229-234