Book contents
- Non-Motor Parkinson’s Disease
- Non-Motor Parkinson’s Disease
- Copyright page
- Contents
- Contributors
- Introduction
- Chapter 1 Parkinson’s Disease: An Overview of the Non-Motor Symptomatology
- Chapter 2 Evaluation of the Patient with Parkinson’s Disease in the Early Stages: Non-Motor Phase
- Chapter 3 Non-Motor Symptoms in Late-Stage Parkinson’s Disease
- Chapter 4 Neuropathology of Non-Motor Parkinson’s Disease Symptoms
- Chapter 5 Neuroimaging Studies in Non-Motor Parkinson’s Disease Symptoms
- Chapter 6 Mild Cognitive Impairment
- Chapter 7 Cognitive Dysfunction in Parkinson’s Disease
- Chapter 8 Neuropsychiatric (Behavioral) Symptoms in Parkinson’s Disease
- Chapter 9 Mood Disorders in Parkinson’s Disease
- Chapter 10 Olfactory Dysfunction in Parkinson’s Disease and Related Disorders
- Chapter 11 Oculomotor and Visual-Vestibular Disturbances in Parkinson’s Disease
- Chapter 12 Autonomic Dysfunction and Failure in Parkinson’s Disease
- Chapter 13 Gastrointestinal Disturbances in Parkinson’s Disease Including the Management of Sialorrhea
- Chapter 14 Sexual Dysfunction in Parkinson’s Disease
- Chapter 15 Sleep Disturbances in Parkinson’s Disease
- Chapter 16 Musculoskeletal Disorders and Pain in Parkinson’s Disease
- Chapter 17 Cutaneous Manifestations of Parkinson’s Disease
- Chapter 18 Genetics of Non-Motor Symptoms of Parkinson’s Disease
- Chapter 19 Drug-Induced Non-Motor Symptoms in Parkinson’s Disease
- Chapter 20 Impulse Control Disorders and the Dopamine Dysregulation Syndrome
- Chapter 21 Serotonin Syndrome and Drug Interactions, Hypertensive Complications, and, Adverse Effects of Monoamine Oxidase Inhibitors in Patients with Parkinson’s Disease
- Chapter 22 Parkinson’s Disease and Pregnancy
- Index
- Plate Section (PDF Only)
- References
Chapter 5 - Neuroimaging Studies in Non-Motor Parkinson’s Disease Symptoms
Published online by Cambridge University Press: 05 March 2022
- Non-Motor Parkinson’s Disease
- Non-Motor Parkinson’s Disease
- Copyright page
- Contents
- Contributors
- Introduction
- Chapter 1 Parkinson’s Disease: An Overview of the Non-Motor Symptomatology
- Chapter 2 Evaluation of the Patient with Parkinson’s Disease in the Early Stages: Non-Motor Phase
- Chapter 3 Non-Motor Symptoms in Late-Stage Parkinson’s Disease
- Chapter 4 Neuropathology of Non-Motor Parkinson’s Disease Symptoms
- Chapter 5 Neuroimaging Studies in Non-Motor Parkinson’s Disease Symptoms
- Chapter 6 Mild Cognitive Impairment
- Chapter 7 Cognitive Dysfunction in Parkinson’s Disease
- Chapter 8 Neuropsychiatric (Behavioral) Symptoms in Parkinson’s Disease
- Chapter 9 Mood Disorders in Parkinson’s Disease
- Chapter 10 Olfactory Dysfunction in Parkinson’s Disease and Related Disorders
- Chapter 11 Oculomotor and Visual-Vestibular Disturbances in Parkinson’s Disease
- Chapter 12 Autonomic Dysfunction and Failure in Parkinson’s Disease
- Chapter 13 Gastrointestinal Disturbances in Parkinson’s Disease Including the Management of Sialorrhea
- Chapter 14 Sexual Dysfunction in Parkinson’s Disease
- Chapter 15 Sleep Disturbances in Parkinson’s Disease
- Chapter 16 Musculoskeletal Disorders and Pain in Parkinson’s Disease
- Chapter 17 Cutaneous Manifestations of Parkinson’s Disease
- Chapter 18 Genetics of Non-Motor Symptoms of Parkinson’s Disease
- Chapter 19 Drug-Induced Non-Motor Symptoms in Parkinson’s Disease
- Chapter 20 Impulse Control Disorders and the Dopamine Dysregulation Syndrome
- Chapter 21 Serotonin Syndrome and Drug Interactions, Hypertensive Complications, and, Adverse Effects of Monoamine Oxidase Inhibitors in Patients with Parkinson’s Disease
- Chapter 22 Parkinson’s Disease and Pregnancy
- Index
- Plate Section (PDF Only)
- References
Summary
It is now accepted that Parkinson’s disease (PD) is a multi-system disorder associated not only with progressive assymetric limb bradykinesia, rigidity, rest tremor, and later postural impairment and gait difficulties, but also with dementia, depression, daytime somnolence, REM sleep behavior disorder, and autonomic dysfunction [1]. Pathologically PD is characterized by neuronal inclusions of abnormally aggregated α-synuclein in the form of Lewy bodies and neurites [2]. These target the nigro-striatal and meso-frontal dopaminergic projections impairing limb movement and executive functions, respectively. They also cause cholinergic neuronal loss from the nucleus basalis leading to attentional and memory deficits, serotonergic neuronal loss from the median raphe nuclei leading to affective and sleep disorders, and noradrenergic neuronal loss from the locus ceruleus resulting in REM sleep behavior disorder (RBD), depression, and anxiety.
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- Non-motor Parkinson's Disease , pp. 46 - 61Publisher: Cambridge University PressPrint publication year: 2022