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Chapter 42 - Conclusions

from Section 8 - The transplant service

Published online by Cambridge University Press:  07 September 2011

Andrew A. Klein
Affiliation:
Papworth Hospital NHS Trust
Clive J. Lewis
Affiliation:
Papworth Hospital NHS Trust
Joren C. Madsen
Affiliation:
Massachusetts General Hospital
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Summary

This is the concluding chapter of the book Organ Transplantation, which has considered the most commonly transplanted tissues and solid organs, yet much research continues in the cell laboratory, in animal models, and in early human clinical studies. It outlines uterus transplantation, ovary transplantation, thymus transplantation, cardiac valves and vessels and cell-based therapies. Experimental animal studies have established the feasibility of uterus transplant, including donor retrieval techniques, cold ischemic tolerance of greater than 24 hours, and the surgical implant procedure, although problems remain with vascular anastomosis and thrombosis. Research in ovary transplantation was largely taken over by the successes of in vitro fertilization and uterine implantation. Thymus transplantation has been used to treat the rare condition of complete athymia in Di George syndrome. A number of stem cell therapeutics exist, but most are at experimental stages.
Type
Chapter
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Organ Transplantation
A Clinical Guide
, pp. 355 - 356
Publisher: Cambridge University Press
Print publication year: 2011

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