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Chapter 37 - Cystic Fibrosis in Pregnancy

from Section 6 - Cardiopulmonary Conditions in Pregnancy

Published online by Cambridge University Press:  23 February 2023

By
Jennifer Landry  and
Amira El-Messidi
Edited by
Amira El-Messidi  and
Alan D. Cameron
Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

A 26-year-old Caucasian primigravida with cystic fibrosis (CF) is referred by her primary care provider for prenatal care of her desired pregnancy. Dating ultrasound has just confirmed a viable singleton intrauterine pregnancy at 8+0 weeks’ gestation.

Keywords

Cystic fibrosis, maternalPoor obstetric outcome, risk factorsGenetics, risk assessment calculationContraindications, pregnancyInhaled tobramycin, cystic fibrosis transmembrane conductance regulator (CFTR) modulatorPerinatal risksPregnancy-associated disease comorbiditiesFetal manifestations, sonographyMaternal morbidity, mortalityAntenatal, intrapartum, postpartum managementContraception
Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
 , pp. 479 - 487
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Readings

Edenborough, FP, Borgo, G, Knoop, C, et al. European Cystic Fibrosis Society. Guidelines for the management of pregnancy in women with cystic fibrosis. J Cyst Fibros. 2008;7 (Suppl 1):S2–32.CrossRefGoogle ScholarPubMed
Geake, J, Tay, G, Callaway, L, et al. Pregnancy and cystic fibrosis: approach to contemporary management. Obstet Med. 2014; 7(4):147–155.CrossRefGoogle ScholarPubMed
Grigoriadis, C, Tympa, A, Theodoraki, K. Cystic fibrosis and pregnancy: counseling, obstetrical management and perinatal outcome. Invest Clin. 2015; 56(1):66–72.Google ScholarPubMed
Heltshe, SL, Godfrey, EM, Josephy, T, et al. Pregnancy among cystic fibrosis women in the era of CFTR modulators. J Cyst Fibros. 2017;16(6):687–694.CrossRefGoogle ScholarPubMed
Lau, EMT, Moriarty, C, Ogle, R, et al. Pregnancy and cystic fibrosis. Paediatr Respir Rev. 2010; 11:90–94.CrossRefGoogle ScholarPubMed
McArdle, J. Pregnancy in cystic fibrosis. Clin Chest Med. 2011; 32:111–120.CrossRefGoogle ScholarPubMed
Middleton, PG, Gade, EJ, Aguilera, C, et al. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J. 2020;55:1901208.CrossRefGoogle ScholarPubMed
Panchaud, A, Di Paolo, ER, Koutsokera, A, et al. Safety of drugs during pregnancy and breastfeeding in cystic fibrosis patients. Respiration. 2016;91(4):333–348.CrossRefGoogle ScholarPubMed
Roe, AH, Traxler, S, Schreiber, CA. Contraception in women with cystic fibrosis: a systematic review of the literature. Contraception. 2016; 93:3–10.CrossRefGoogle ScholarPubMed
Whitty, JE. Cystic fibrosis and pregnancy. Clin Obstetr Gynecol. 2010;53(2):369–376.CrossRefGoogle Scholar

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