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Chapter 18 - Pharmacokinetics, Pharmacodynamics and Teratogenesis

Published online by Cambridge University Press:  27 July 2023

By
Kevin Hayes
Edited by
Asma Khalil  and
Anthony Griffiths
Asma Khalil
Affiliation:
St George's University of London
Anthony Griffiths
Affiliation:
University Hospital of Wales, Cardiff
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Summary

Volume of distribution (VD) is the theoretical volume of water in which the amount of drug would need to be uniformly distributed to produce an observed blood concentration. Fat-soluble drugs may have an enormous VD and they may have prolonged duration of action, as they can have a reservoir in fat tissue.

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Chapter
Information
Part 1 MRCOG Synoptic Revision Guide , pp. 169 - 178
Publisher: Cambridge University Press
Print publication year: 2023

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References

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Cardonick, E, Iacobucci, A. Use of chemotherapy during human pregnancy. Lancet Oncol. 2004 May;5(5):283–91.Google Scholar

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