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Case 77 - Brown fat on PET/CT

Published online by Cambridge University Press:  07 October 2011

Thomas Hartman
Affiliation:
Mayo Clinic, Rochester
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Summary

Imaging description

Brown adipose tissue is extremely important in regulating energy expenditure and maintaining normal body temperature in newborn infants. The absolute amount and percentage of brown fat versus white fat decreases with age. In the past, brown fat was not thought to play a role in adult temperature control. PET/CT scanning demonstrates the presence of brown fat activation in adults by intense FDG uptake (Figure 77.1). Colder temperatures and anxiety enhance FDG uptake. On PET/CT, FDG uptake in brown fat is predominantly located in the neck, supraclavicular and paravertebral areas, and is inversely related to body mass index (BMI) and percent body fat. Children and adolescents may have FDG uptake in brown fat in the upper abdomen and adjacent to the diaphragm [1–3].

Importance

The intense irregular FDG accumulation produced by brown fat activation can mimic nodal disease, potentially leading to unnecessary workup and treatment if misinterpreted. Alternatively, brown fat activation can obscure small or subtle foci of recurrent disease.

Type
Chapter
Information
Pearls and Pitfalls in Thoracic Imaging
Variants and Other Difficult Diagnoses
, pp. 202 - 203
Publisher: Cambridge University Press
Print publication year: 2011

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References

Paidisetty, SBlodgett, TM.Brown fat: atypical locations and appearances encountered in PET/CTAJR Am J Roentgenol 2009 193 359CrossRefGoogle ScholarPubMed
Saito, MOkamatsu-Ogura, YMatsushita, MHigh incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposityDiabetes 2009 58 1526CrossRefGoogle ScholarPubMed
Cypess, AMLehman, SWilliams, GIdentification and importance of brown adipose tissue in adult humansN Engl J Med 2009 360 1509CrossRefGoogle ScholarPubMed
Sturkenboom, MGHoekstra, OSPostema, EJA randomised controlled trial assessing the effect of oral diazepam on 18F-FDG uptake in the neck and upper chest regionMol Imaging Biol 2009 11 364CrossRefGoogle ScholarPubMed

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