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Chapter 15 - Myeloid Neoplasms with Germline Predisposition

from Section IV - Neoplastic Disorders of Bone Marrow

Published online by Cambridge University Press:  25 January 2024

By
Bradford Siegele
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

Myelodysplastic syndromes (MDSs) and acute myeloid leukemias (AMLs), although most frequently occurring sporadically and in adult populations, have additionally been noted to occur in association with predisposing germline genetic abnormalities, with such cases commonly occurring in children and young adults. With the utilization of advanced diagnostic methodologies in clinical practice and the recognition of the significance of this set of conditions for clinical management, the spectrum of syndromic conditions has continued to expand in the medical literature.

Type
Chapter
Information
Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 189 - 195
Publisher: Cambridge University Press
Print publication year: 2024

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