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Chapter 6 - Pharmacokinetic Modelling

from Section I - Basic Principles

Published online by Cambridge University Press:  26 February 2021

Tom Peck  and
Benjamin Harris
Tom Peck
Affiliation:
Royal Hampshire County Hospital, Winchester and University Hospital Southampton
Benjamin Harris
Affiliation:
Hampshire Hospitals NHS Trust
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Summary

Pharmacokinetics is the study of the way in which the body handles administered drugs. The use of mathematical models allows us to predict how plasma concentration changes with time when the dose and interval between doses are changed, or when infusions of a drug are used. Because there is an association between plasma concentration of a drug and its pharmacodynamic effect, models allow us to predict the extent and duration of clinical effects. Mathematical models may therefore be used to programme computers to deliver a variable rate infusion to achieve a predetermined plasma level and hence a desired therapeutic effect.

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Pharmacology for Anaesthesia and Intensive Care , pp. 47 - 67
Publisher: Cambridge University Press
Print publication year: 2021

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