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Chapter 20 - Physical Health of People with Mental Illness

from Section 2 - Clinical Issues

Published online by Cambridge University Press:  10 September 2018

By
Richard Holt ,
David Shiers  and
Robert Peveler
Edited by
Linda Gask ,
Tony Kendrick ,
Robert Peveler  and
Carolyn A. Chew-Graham
Linda Gask
Affiliation:
University of Manchester
Tony Kendrick
Affiliation:
University of Southampton
Robert Peveler
Affiliation:
University of Southampton
Carolyn A. Chew-Graham
Affiliation:
Keele University
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Chapter
Information
Primary Care Mental Health , pp. 277 - 299
Publisher: Cambridge University Press
Print publication year: 2018

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References

Further Reading and E-resources

Academy of Royal Medical Colleges (2016) Improving the Physical Health of Adults with Severe Mental Illness: Essential Actions. A report of the Academy of Medical Royal Colleges and the Royal Colleges of General Practitioners, Nursing, Pathologists, Psychiatrists, Physicians, the Royal Pharmaceutical Society and Public Health England. www.rcpsych.ac.uk/files/pdfversion/OP100.pdfGoogle Scholar
Cooper, SJ, Reynolds, GP, Barnes, TRE, et al. (2016) BAP guidelines on the management of weight gain, metabolic disturbances and cardiovascular risk associated with psychosis and antipsychotic drug treatment. Journal of Psychopharmacology, 30, 717–748.Google Scholar
Liu, NH, Daumit, GL, Dua, T, et al. (2017) Excess mortality in persons with severe mental disorders: a multilevel intervention framework and priorities for clinical practice, policy and research agendas. World Psychiatry, 16(1), 30–40.Google Scholar
NICE (2014) Bipolar disorder: assessment and management. www.nice.org.uk/guidance/cg185. Last updated February 2016.Google Scholar
NICE (2014) Psychosis and schizophrenia in adults: treatment and management. CG178. www.nice.org.uk/Guidance/cg178. Last updated March 2014.Google Scholar
Shiers, D, Rafi, I, Cooper, SJ, et al. (2014) 2014 update (with acknowledgement to the late Helen Lester for her contribution to the original 2012 version) Positive Cardiometabolic Health Resource: An Intervention Framework for Patients with Psychosis and Schizophrenia. Royal College of Psychiatrists.Google Scholar

References

Allison, DB, Mentore, JL, Heo, M, et al. (1999) Antipsychotic-induced weight gain: a comprehensive research synthesis. American Journal of Psychiatry, 156, 1686–1696.Google Scholar
Alvarez-Jimenez, M, Gonzalez-Blanch, C, Crespo-Facorro, B, et al. (2008) Antipsychotic-induced weight gain in chronic and first-episode psychotic disorders: a systematic critical reappraisal. CNS Drugs, 22, 547–562.Google Scholar
Amaddeo, F, Barbui, C, Perini, G, et al. (2007) Avoidable mortality of psychiatric patients in an area with a community-based system of mental health care. Acta Psychiatrica Scandinavica, 115, 4, 320–325.Google Scholar
Appel, LJ, Champagne, CM, Harsha, DW, et al. (2003) Effects of comprehensive lifestyle modification on blood pressure control: main results of the PREMIER clinical trial. JAMA, 289, 2083–2093.Google ScholarPubMed
Barnard, K, Peveler, RC, Holt, RI (2013) Antidepressant medication as a risk factor for type 2 diabetes and impaired glucose regulation: systematic review. Diabetes Care, 36, 3337–3345.Google Scholar
Bartels, SJ (2015) Can behavioral health organizations change health behaviors? The STRIDE study and lifestyle interventions for obesity in serious mental illness. American Journal of Psychiatry, 172, 9–11.Google Scholar
Brown, S, Kim, M, Mitchell, C, et al. (2010) Twenty-five year mortality of a community cohort with schizophrenia. British Journal of Psychiatry, 196, 116–121.Google Scholar
Bushe, C, Paton, C (2005) The potential impact of antipsychotics on lipids in schizophrenia: is there enough evidence to confirm a link? Journal of Psychopharmacoogyl, 19 (6 Suppl), 76–83.Google Scholar
Caemmerer, J, Correll, CU, Maayan, L (2012) Acute and maintenance effects of non-pharmacologic interventions for antipsychotic associated weight gain and metabolic abnormalities: a meta-analytic comparison of randomized controlled trials. Schizophrenia Research, 140, 159–168.Google Scholar
Chang, CK, Hayes, RD, Perera, G, et al. (2011) Life expectancy at birth for people with serious mental illness and other major disorders from a secondary mental health care case register in London. PLoS One, 6, 5, e19590.Google Scholar
Citrome, L, Holt, RI, Walker, DJ, et al. (2011) Weight gain and changes in metabolic variables following olanzapine treatment in schizophrenia and bipolar disorder. Clinical Drug Investigation, 31, 455–482.Google Scholar
Citrome, L, Yeomans, D (2005) Do guidelines for severe mental illness promote physical health and well-being? Journal of Psychopharmacology, 19, 102–109.CrossRefGoogle ScholarPubMed
Cooper, J, Mancuso, SG, Borland, R, et al. (2012) Tobacco smoking among people living with a psychotic illness: the second Australian Survey of Psychosis. Australia and New Zealand Journal of Psychiatry, 46, 851–863.CrossRefGoogle ScholarPubMed
Cooper, SJ, Reynolds, GP, et al. (2016) BAP guidelines on the management of weight gain, metabolic disturbances and cardiovascular risk associated with psychosis and antipsychotic drug treatment. Journal of Psychopharmacology, 30, 717–748.Google Scholar
Correll, CU, Robinson, DG, Schooler, NR, et al. (2014) Cardiometabolic risk in patients with first-episode schizophrenia spectrum disorders: baseline results from the RAISE-ETP study. JAMA Psychiatry, 71, 1350–1363.Google Scholar
Cournos, F, McKinnon, K, Sullivan, G (2005) Schizophrenia and comorbid human immunodeficiency virus or hepatitis C virus. Journal of Clinical Psychiatry, 66, Suppl 6, 27–33.Google Scholar
Crawford, MJ, Jayakumar, S, Lemmey, SJ, et al. (2014) Assessment and treatment of physical health problems among people with schizophrenia: national cross-sectional study. British Journal of Psychiatry, 205, 473–477.Google Scholar
Curtis, J, Newall, HD, Samaras, K (2012) The heart of the matter: cardiometabolic care in youth with psychosis. Early Intervention Psychiatry, 6, 347–353.Google Scholar
Curtis, J, Watkins, A, Rosenbaum, S, et al. (2016) Evaluating an individualized lifestyle and life skills intervention to prevent antipsychotic-induced weight gain in first-episode psychosis. Early Intervention Psychiatry, 10, 267–276.Google Scholar
De Hert, M, Correll, CU, Bobes, J, et al. (2011) Physical illness in patients with severe mental disorders. I. Prevalence, impact of medications and disparities in health care. World Psychiatry, 10, 52–77.Google Scholar
De Hert, M, Dekker, JM, Wood, D, et al. (2009) Cardiovascular disease and diabetes in people with severe mental illness: position statement from the European Psychiatric Association (EPA), supported by the European Association for the Study of Diabetes (EASD) and the European Society of Cardiology (ESC). European Psychiatry, 24, 412–424.Google Scholar
Doll, R, Peto, R, Boreham, J, et al. (2004) Mortality in relation to smoking: 50 years’ observations on male British doctors. BMJ, 328, 1519. doi: 10.1136/bmj.38142.554479.AEGoogle Scholar
Foley, DL, Mackinnon, A, Morgan, VA, et al. (2016) Awareness of pre-diabetes or diabetes and associated factors in people with psychosis. Schizophrenia Bulletin, 42, 1280–1289.Google Scholar
Galling, B, Roldan, A, Nielsen, RE, et al. (2016) Type 2 diabetes mellitus in youth exposed to antipsychotics: a systematic review and meta-analysis. JAMA Psychiatry, 73, 247–259.Google Scholar
Hanssens, L, De Hert, M, Kalnicka, D, et al. (2007) Pharmacological treatment of severe dyslipidaemia in patients with schizophrenia. International Clinical Psychopharmacology, 22, 43–49.Google Scholar
Hoang, U, Stewart, R, Goldacre, MJ (2011) Mortality after hospital discharge for people with schizophrenia or bipolar disorder: retrospective study of linked English hospital episode statistics, 1999–2006. BMJ, 343, d5422 doi: 10.1136/bmj.d5422CrossRefGoogle ScholarPubMed
Holt, RI (2010) Osteoporosis in people with severe mental illness: a forgotten condition. Maturitas, 67, 1–2.Google Scholar
Holt, RI (2015) The prevention of diabetes and cardiovascular disease in people with schizophrenia. Acta Psychiatrica Scandinavica, 132, 86–96.Google Scholar
Holt, RI, de Groot, M, Golden, SH (2014) Diabetes and depression. Current Diabetes Reports, 14, 491.Google Scholar
Holt, RI, Mitchell, AJ (2015) Diabetes mellitus and severe mental illness: mechanisms and clinical implications. Nature Reviews Endocrinology, 11, 79–89.Google Scholar
Holt, RI, Pendlebury, J, Wildgust, HJ, et al. (2010) Intentional weight loss in overweight and obese patients with severe mental illness: 8-year experience of a behavioral treatment program. Journal of Clinical Psychiatry, 71, 800–805.Google Scholar
Holt, RI, Peveler, RC (2009) Obesity, serious mental illness and antipsychotic drugs. Diabetes Obesity and Metabolism, 11, 665–679.Google Scholar
Holt, RI, Peveler, RC (2011) Antipsychotics and hyperprolactinaemia: mechanisms, consequences and management. Clinical Endocrinology, 74, 141–147.Google Scholar
Homel, P, Casey, D, Allison, DB (2002) Changes in body mass index for individuals with and without schizophrenia, 1987–1996. Schizophrenia Research, 55, 277–284.Google Scholar
Kahn, RS, Fleischhacker, WW, Boter, H, et al. (2008) Effectiveness of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: an open randomised clinical trial. Lancet, 371, 1085–1097.CrossRefGoogle ScholarPubMed
Kendrick, T (1996) Cardiovascular and respiratory risk factors and symptoms among general practice patients with long-term mental illness. British Journal of Psychiatry, 169, 733–739.Google Scholar
Kendrick, T, Burns, T, Freeling, P (1995) Randomised controlled trial of teaching general practitioners to carry out structured assessments of their long term mentally ill patients. BMJ, 311, 93–98.CrossRefGoogle ScholarPubMed
Laursen, TM (2011) Life expectancy among persons with schizophrenia or bipolar affective disorder. Schizophrenia Research, 131, 101–104.Google Scholar
Laursen, TM, Nordentoft, M, Mortensen, PB (2014) Excess early mortality in schizophrenia. Annual Review of Clinical Psychology, 10, 425–448.Google Scholar
Lester, H (2013) The James Mackenzie Lecture 2012: bothering about Billy. British Journal of General Practice, 63, e232-4. doi: 10.3399/bjgp13X664414Google Scholar
Lester, H, Tritter, JQ, Sorohan, H (2005) Patients’ and health professionals’ views on primary care for people with serious mental illness: focus group study. BMJ, 330, 1122. doi: 10.1136/bmj.38440.418426.8 FGoogle Scholar
Mezuk, B, Eaton, WW, Albrecht, S, et al. (2008) Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care, 31, 2383–2390.Google Scholar
Mitchell, AJ, Malone, D, Doebbeling, CC (2009) Quality of medical care for people with and without comorbid mental illness and substance misuse: systematic review of comparative studies. British Journal of Psychiatry, 194, 491–499.CrossRefGoogle ScholarPubMed
Mitchell, AJ, Vancampfort, D, De Herdt, A, et al. (2013) Is the prevalence of metabolic syndrome and metabolic abnormalities increased in early schizophrenia? A comparative meta-analysis of first episode, untreated and treated patients. Schizophrenia Bulletin, 39, 295–305.Google Scholar
Mizuno, Y, Suzuki, T, Nakagawa, A, et al. (2014) Pharmacological strategies to counteract antipsychotic-induced weight gain and metabolic adverse effects in schizophrenia: a systematic review and meta-analysis. Schizophrenia Bulletin, Nov;40, 6, 1385–1403. doi: 10.1093/schbul/sbu030. Epub 2014 Mar 17Google Scholar
Myles, N, Newall, HD, Curtis, J, et al. (2012) Tobacco use before, at, and after first-episode psychosis: a systematic meta-analysis. Journal of Clinical Psychiatry, 73, 468–475.Google Scholar
Nazareth, I, King, M, Tai, SS (1996) Monitoring psychosis in general practice: a controlled trial. British Journal of Psychiatry, 169, 475–482.Google Scholar
NHS Employers BMA, NHS England (2016) 2016/17 General Medical Services (GMS) Contract Quality and Outcomes Framework (QOF); Guidance for GMS Contract 2016/17. NHS Employers. Gateway ref No. 05093.Google Scholar
National Institute for Health and Care Excellence (NICE) (2011) National Institute for Health and Care Excellence. Hypertension: Clinical Management of Primary Hypertension in Adults. CG127. National Institute for Health and Care Excellence.Google Scholar
National Institute for Health and Care Excellence (NICE) (2012) National Institute for Health and Clinical Excellence. Preventing Type 2 Diabetes: Risk Identification and Interventions for Individuals at High Risk. PHG38. National Institute for Health and Care Excellence.Google Scholar
National Institute for Health and Care Excellence (NICE) (2014a) National Collaborating Centre for Mental Health. Psychosis and Schizophrenia in Adults: Treatment and Management. CG178. National Institute for Health and Care Excellence.Google Scholar
National Institute for Health and Care Excellence (NICE) (2014b) National Institute for Health and Care Excellence. Lipid Modification: Cardiovascular Risk Assessment and the Modification of Blood Lipids for the Primary and Secondary Prevention of Cardiovascular Disease. CG181. National Institute for Health and Care Excellence.Google Scholar
NICE Primary Care Quality and Outcomes Framework Indicator Advisory Committee (2013) Minutes of Extraordinary Meeting 18 September 2013. Available from: www.nice.org.uk/media/default/Get-involved/Meetings-In-Public/QOF-Advisory-Committee/QOF-minutes-18-September-2013.pdfGoogle Scholar
Nielsen, RE, Uggerby, AS, Jensen, SO, et al. (2013) Increasing mortality gap for patients diagnosed with schizophrenia over the last three decades – a Danish nationwide study from 1980 to 2010. Schizophrenia Research, 146, 22–27.Google Scholar
Nordentoft, M, Wahlbeck, K, Hallgren, J, et al. (2013) Excess mortality, causes of death and life expectancy in 270,770 patients with recent onset of mental disorders in Denmark, Finland and Sweden. PLoS One, 8, 1, e55176.Google Scholar
Norris, SL, Kansagara, D, Bougatsos, C, et al. (2008) Screening adults for type 2 diabetes: a review of the evidence for the U.S. Preventive Services Task Force. Annals of Internal Medicine, 148, 855–868.Google Scholar
Nouwen, A, Winkley, K, Twisk, J, et al. (2010) Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia, 53, 2480–2486.Google Scholar
Osborn, DP, Hardoon, S, Omar, RZ, et al. (2015) Cardiovascular risk prediction models for people with severe mental illness: results from the Prediction and Management of Cardiovascular Risk in People With Severe Mental Illnesses (PRIMROSE) research program. JAMA Psychiatry, 72, 143–151.Google Scholar
Osborn, DP, King, MB, Nazareth, I (2003) Participation in screening for cardiovascular risk by people with schizophrenia or similar mental illnesses: cross sectional study in general practice. BMJ, 326, 1122–1123.Google Scholar
Osborn, DP, Levy, G, Nazareth, I, et al. (2007) Relative risk of cardiovascular and cancer mortality in people with severe mental illness from the United Kingdom’s General Practice Research Database. Archives of General Psychiatry, 64, 242–249.CrossRefGoogle Scholar
Osborn, DP, Wright, CA, Levy, G, et al. (2008) Relative risk of diabetes, dyslipidaemia, hypertension and the metabolic syndrome in people with severe mental illnesses: systematic review and metaanalysis. BMC Psychiatry, 8, 84.Google Scholar
Partti, K, Vasankari, T, Kanervisto, M, et al. (2015) Lung function and respiratory diseases in people with psychosis: population-based study. British Journal of Psychiatry 207, 37–45.Google Scholar
Petrak, F, Baumeister, H, Skinner, TC, et al. (2015) Depression and diabetes: treatment and health-care delivery. Lancet Diabetes and Endocrinology, 3, 472–485.Google Scholar
Reilly, S, Planner, C, Hann, M, et al. (2012) The role of primary care in service provision for people with severe mental illness in the United Kingdom. PLoS One, 7, 5, e36468.Google Scholar
Seminog, OO, Goldacre, MJ (2013) Risk of pneumonia and pneumococcal disease in people hospitalized with diabetes mellitus: English record-linkage studies. Diabetic Medicine, 30, 1412–1419.Google Scholar
Shiers, D, Rafi, I, Cooper, SJ, et al. (2014) 2014 update (with acknowledgement to the late Helen Lester for her contribution to the original 2012 version) Positive Cardiometabolic Health Resource: An Intervention Framework for Patients with Psychosis and Schizophrenia. Royal College of Psychiatrists.Google Scholar
Smith, DJ, Langan, J, McLean, G, et al. (2013a) Schizophrenia is associated with excess multiple physical-health comorbidities but low levels of recorded cardiovascular disease in primary care: cross-sectional study. BMJ Open, 3, 4, pii: e002808.CrossRefGoogle ScholarPubMed
Smith, DJ, Martin, D, McLean, G, et al. (2013b) Multimorbidity in bipolar disorder and undertreatment of cardiovascular disease: a cross sectional study. BMC Medicine, 11, 263.Google Scholar
Subramaniam, M, Chong, SA, Pek, E (2003) Diabetes mellitus and impaired glucose tolerance in patients with schizophrenia. Canadian Journal of Psychiatry, 48, 345–347.Google Scholar
Taylor, D, Young, C, Mohamed, R, et al. (2005) Undiagnosed impaired fasting glucose and diabetes mellitus amongst inpatients receiving antipsychotic drugs. Journal of Psychopharmacology, 19, 182–186.Google Scholar
Taylor, FC, Huffman, M, Ebrahim, S (2013a) Statin therapy for primary prevention of cardiovascular disease. JAMA, 310, 2451–2452.Google Scholar
Taylor, J, Cottrell, C, Chatterton, H, et al. (2013b) Identifying risk and preventing progression to Type 2 diabetes in vulnerable and disadvantaged adults: a pragmatic review. Diabetic Medicine, 30, 16–25.Google Scholar
Witchel, HJ, Hancox, JC, Nutt, DJ (2003) Psychotropic drugs, cardiac arrhythmia, and sudden death. Journal of Clinical Psychopharmacology, 23, 58–77.Google Scholar
Yi-Hua, Chen, Hsiu-Chen, Lin, Herng-Ching, Lin (2011) Poor clinical outcomes among pneumonia patients with schizophrenia. Schizophrenia Bulletin, 37, 1088–1094.Google Scholar
Yusuf, S, Hawken, S, Ounpuu, S, et al. (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet, 364, 937–952.Google Scholar

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