Book contents
- Frontmatter
- Contents
- List of Contributors
- Foreword by Daniel R. Salomon
- Foreword by Robin Marks
- Foreword by Kathy Schwab
- Preface
- Acknowledgments
- SECTION ONE TRANSPLANT DERMATOLOGY: AN EVOLVING DYNAMIC FIELD
- Section Two Transplant Medicine and Dermatology
- 2 The History of Organ Transplantation
- 3 The Development of Modern Immunosuppressive Medications
- 4 Organ Transplantation: Current Status and Practice
- 5 The Immunology of Transplantation and Allograft Rejection
- 6 Allograft-Specific Considerations in Transplant Dermatology
- 7 Dermatologic Disease from the Transplant Perspective
- Section Three Pathogenic Factors in Transplant Dermatology
- Section Four Cutaneous Effects of Immunosuppressive Medications
- Section Five Infectious Diseases of the Skin in Transplant Dermatology
- Section Six Benign and Inflammatory Skin Diseases in Transplant Dermatology
- Section Seven Cutaneous Oncology in Transplant Dermatology
- Section Eight Special Scenarios in Transplant Cutaneous Oncology
- Section Nine Educational, Organizational, and Research Efforts in Transplant Dermatology
- Index
6 - Allograft-Specific Considerations in Transplant Dermatology
from Section Two - Transplant Medicine and Dermatology
Published online by Cambridge University Press: 18 January 2010
- Frontmatter
- Contents
- List of Contributors
- Foreword by Daniel R. Salomon
- Foreword by Robin Marks
- Foreword by Kathy Schwab
- Preface
- Acknowledgments
- SECTION ONE TRANSPLANT DERMATOLOGY: AN EVOLVING DYNAMIC FIELD
- Section Two Transplant Medicine and Dermatology
- 2 The History of Organ Transplantation
- 3 The Development of Modern Immunosuppressive Medications
- 4 Organ Transplantation: Current Status and Practice
- 5 The Immunology of Transplantation and Allograft Rejection
- 6 Allograft-Specific Considerations in Transplant Dermatology
- 7 Dermatologic Disease from the Transplant Perspective
- Section Three Pathogenic Factors in Transplant Dermatology
- Section Four Cutaneous Effects of Immunosuppressive Medications
- Section Five Infectious Diseases of the Skin in Transplant Dermatology
- Section Six Benign and Inflammatory Skin Diseases in Transplant Dermatology
- Section Seven Cutaneous Oncology in Transplant Dermatology
- Section Eight Special Scenarios in Transplant Cutaneous Oncology
- Section Nine Educational, Organizational, and Research Efforts in Transplant Dermatology
- Index
Summary
Solid organ transplantation has evolved from a highly experimental and risky procedure to the standard of care and the treatment of choice of end-stage organ failure in the past four decades. For practical purposes, the first successful kidney transplant by Murray in the 1950s, followed by a successful heart transplant by Barnard heralded a new age of promise for patients with end-stage organ disease. The goals underlying all solid organ transplantation are unified: replacement of a dysfunctional host organ with a transplanted allograft that restores the function of the compromised organ. However, there are many subtle and profound differences between various aspects of organ transplantation specific to the type of allograft being transplanted, including the patient population, alternative therapies, donor population, immunogenicity of allografts, immunosuppressive regimens, risk of rejection, and the consequences of rejection/allograft loss. These considerations are relevant to transplant dermatology in important ways including the susceptibility of the patient population to specific skin diseases, particularly skin cancer, the relative carcinopermissiveness of the immunosuppressive regimen, the degree to which reduction or alteration of immunosuppression is possible, and the consequences if reduction of immunosuppression results in allograft rejection/loss. This chapter will consider these issues for each major allograft type, which are summarized in Table 6.1.
Because the relative immunogenicity of various allografts is integral to the considerations of this chapter, we present a rough approximation of immunogenicity.
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- Information
- Skin Disease in Organ Transplantation , pp. 39 - 45Publisher: Cambridge University PressPrint publication year: 2008