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Chapter 21 - The Risks of Assisted Reproduction

Published online by Cambridge University Press:  03 June 2019

By
Neil McClure
Edited by
Jane A. Stewart
Jane A. Stewart
Affiliation:
Newcastle Hospitals NHS Foundation Trust
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Summary

Assisted reproductive techniques (ART) are now responsible for more than 2% of all human births in the United Kingdom and closer to 5% in mainland Europe. According to the Human Fertilisation and Embryology Authority (HFEA), 63,600 cycles of treatment were performed in 2013 alone in the United Kingdom [1]. Despite being so common, the ART ‘industry’ remains one of the most tightly regulated branches of medicine – and probably not without due reason as the consequences of error are potentially huge. This chapter deals, though, with the medical complications of the treatment process and not the ‘social’ complications of embryo mishandling.

Type
Chapter
Information
Subfertility, Reproductive Endocrinology and Assisted Reproduction , pp. 159 - 164
Publisher: Cambridge University Press
Print publication year: 2019

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References

HFEA. Fertility Treatment in 2013: Trends and Figures. 2015.Google Scholar
Aragona, C, Mohamed, MA, Espinola, MS, Linari, A, Pecorini, F, Micara, G, Sbracia, M. Clinical complications after transvaginal oocyte retrieval in 7,098 IVF cycles. Fertil Steril 2011; 95(1): 293–4Google Scholar
HFEA. Adverse Incidents in Fertility Clinics 2014: Lessons to Learn. 2015.Google Scholar
McClure, N, Healy, DL, Rogers, PA, Sullivan, J, Beaton, L, Haning, RV Jr, Connolly, DT, Robertson, DM. Vascular endothelial growth factor as capillary permeability agent in ovarian hyperstimulation syndrome. Lancet 1994; 344(8917): 235–6.Google Scholar
Tso, LO, Costello, MF, Albuquerque, LT, Andriolo, RB, Macedo, CR. Metformin in women with polycystic ovary syndrome for improving fertility. Cochrane Database Syst Rev 2014; Issue 11. Art. No.: CD006105. DOI: 10.1002/14651858.CD006105.pub3.Google Scholar
Tang, H, Hunter, T, Hu, Y, Zhai, S-D, Sheng, X, Hart, RJ. Cabergoline for preventing ovarian hyperstimulation syndrome. Cochrane Database Syst Rev 2012; Issue 2. Art. No.: CD008605. DOI: 10.1002/14651858.CD008605.pub2.CrossRefGoogle Scholar
Youssef, MA, Van der Veen, F, Al-Inany, HG, Mochtar, MH, Griesinger, G, Nagi Mohesen, M, Aboulfoutouh, I, van Wely, M. Gonadotropin-releasing hormone agonist versus HCG for oocyte triggering in antagonist-assisted reproductive technology. Cochrane Database Syst Rev. 2014 Oct; Issue 10. Art. No.: CD008046. DOI: 10.1002/14651858.CD008046.pub4.Google Scholar
Brook, N, Khalaf, Y, Coomarasamy, A, Edgeworth, J, Braude, P. A randomized controlled trial of prophylactic antibiotics (co-amoxiclav) prior to embryo transfer. Hum Reprod 2006; 21(11):2911–15.CrossRefGoogle ScholarPubMed
Kroon, B, Hart, RJ, Wong, BMS, Ford, E, Yazdani, A. Antibiotics prior to embryo transfer in ART. Cochrane Database Syst Rev. 2012; Issue 3. Art. No.: CD008995. DOI: 10.1002/14651858.CD008995.pub2.Google Scholar
Sunkara, SK, Khalaf, Y, Maheshwari, A, Seed, P, Coomarasamy, A. Association between response to ovarian stimulation and miscarriage following IVF: an analysis of 124 351 IVF pregnancies. Hum Reprod 2014; 29(6): 1218–24.Google Scholar
Sunkara, SK, La Marca, A, Seed, PT, Khalaf, Y. Increased risk of preterm birth and low birthweight with very high number of oocytes following IVF: an analysis of 65 868 singleton live birth outcomes. Hum Reprod 2015; 30(6): 1473–80Google Scholar
Londra, L, Moreau, C, Strobino, D, Garcia, J, Zacur, H, Zhao, Y. Ectopic pregnancy after in vitro fertilization: differences between fresh and frozen-thawed cycles. Fertil Steril 2015; 104(1): 110–18.Google Scholar
Braat, DD, Schutte, JM, Bernardus, RE, Mooij, TM, van Leeuwen, FE. Maternal death related to IVF in the Netherlands 1984–2008. Hum Reprod 2010; 25(7): 1782–6.Google Scholar
Lewis, G (ed.). The Confidential Enquiry into Maternal and Child Health (CEMACH). Saving Mothers Lives; Reviewing Maternal Deaths to Make Motherhood Safer 2003–2005. The Seventh Report of the United Kingdom Confidential Enquiries into Maternal Deaths in the United Kingdom. London: CEMACH, 2007.Google Scholar
Knight, M, Kenyon, S, Brocklehurst, P, Neilson, J, Shakespeare, J, Kurinczuk, JJ (eds.) on behalf of MBRRACE-UK. Saving Lives, Improving Mothers’ Care - Lessons learned to inform future maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2009–2012. Oxford: National Perinatal Epidemiology Unit, University of Oxford 2014.Google Scholar
Knight, M, Bunch, K, Tuffnell, D, Jayakody, H, Shakespeare, J, Kotnis, R, Kenyon, S, Kurinczuk, JJ (eds.) on behalf of MBRRACE-UK. Saving Lives, Improving Mothers’ Care - Lessons learned to inform maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2014–2016. Oxford: National Perinatal Epidemiology Unit, University of Oxford 2018.Google Scholar

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