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Chapter 7 - Inflammation, Sickness Behaviour and Depression

Published online by Cambridge University Press:  02 September 2021

By
Golam Khandaker ,
Alessandro Colasanti  and
Neil Harrison
Edited by
Golam Khandaker ,
Neil Harrison ,
Edward Bullmore  and
Robert Dantzer
Golam Khandaker
Affiliation:
University of Cambridge
Neil Harrison
Affiliation:
Cardiff University Brain Research Imaging Centre (CUBRIC)
Edward Bullmore
Affiliation:
University of Cambridge
Robert Dantzer
Affiliation:
University of Texas, MD Anderson Cancer Center
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Summary

The association between infections and changes in mood, motivation and cognition including induction of lethargy, irritability, impaired concentration and memory, lowering of mood, decreased social activity, anhedonia and somnolence has been known for centuries (1). However, it was only in the late 1980s when it was realized that these behavioural changes are the same regardless of the infecting organism (2; 3), and that sickness behaviours represent a critical component of the host response to infection. Indeed, it is now clear that pro-inflammatory cytokines such as interleukin (IL)-1 and tumour necrosis factor-α (TNF-α) that play a central role in coordinating peripheral immune response also play a critical role in triggering systemic responses to infection including fever and sickness behaviours through direct and indirect actions on the brain (4).

Type
Chapter
Information
Textbook of Immunopsychiatry , pp. 109 - 138
Publisher: Cambridge University Press
Print publication year: 2021

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