Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-22T11:14:42.129Z Has data issue: false hasContentIssue false

6 - Immunology of Obsessive-Compulsive and Related Disorders

from Section 1 - Theoretical Foundations of Obsessive-Compulsive and Related Disorders

Published online by Cambridge University Press:  14 December 2018

By
Antonio L. Teixeira ,
Natalia P. Rocha  and
Andrea H. Marques
Edited by
Leonardo F. Fontenelle  and
Murat Yücel
Leonardo F. Fontenelle
Affiliation:
Federal University of Rio de Janeiro
Murat Yücel
Affiliation:
Monash University, Victoria
Get access
Type
Chapter
Information
A Transdiagnostic Approach to Obsessions, Compulsions and Related Phenomena , pp. 51 - 60
Publisher: Cambridge University Press
Print publication year: 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Swedo, SE, Rapoport, JL, Cheslow, DL, et al. High prevalence of obsessive-compulsive symptoms in patients with Sydenham’s chorea. Am J Psychiatry. 1989;146(2):246–249.Google Scholar
Barbosa, IG, Machado-Vieira, R, Soares, JC, Teixeira, AL. The immunology of bipolar disorder. Neuroimmunomodulation. 2014;21(2–3):117–122.Google Scholar
Khandaker, GM, Dantzer, R, Jones, PB. Immunopsychiatry: important facts. Psychol Med. 2017:1–9.Google Scholar
Olsen Saraiva Camara, N, Lepique, AP, Basso, AS. Lymphocyte differentiation and effector functions. Clin Dev Immunol. 2012;2012:510603.Google Scholar
Ziv, Y, Ron, N, Butovsky, O, et al. Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat Neurosci. 2006;9(2):268–275.Google Scholar
de Miranda, AS, Zhang, CJ, Katsumoto, A, Teixeira, AL. Hippocampal adult neurogenesis: does the immune system matter? J Neurol Sci. 2017;372:482–495.Google Scholar
Teixeira, AL, Rodrigues, DH, Marques, AH, Miguel, EC, Fontenelle, LF. Searching for the immune basis of obsessive-compulsive disorder. Neuroimmunomodulation. 2014;21(2–3):152–158.Google Scholar
Taylor, S. Molecular genetics of obsessive-compulsive disorder: a comprehensive meta-analysis of genetic association studies. Mol Psychiatry. 2013;18(7):799–805.Google Scholar
Jia, Y, Qin, HJ, Zhang, JX, Liu, XL, Li, LJ. Association of the tumour necrosis factor-alpha polymorphisms rs361525 and rs1800629 with susceptibility to psoriasis: a meta-analysis. Clin Exp Dermatol. 2013;38(8):836–844.Google Scholar
Baune, BT, Konrad, C, Grotegerd, D, et al. Tumor necrosis factor gene variation predicts hippocampus volume in healthy individuals. Biol Psychiatry. 2012;72(8):655–662.Google Scholar
Rodriguez, N, Morer, A, Gonzalez-Navarro, EA, et al. Human-leukocyte antigen class II genes in early-onset obsessive-compulsive disorder. World J Biol Psychiatry. 2017:1–7.Google Scholar
Maia, DP, Teixeira, AL, Jr, Quintao Cunningham, MC, Cardoso, F. Obsessive compulsive behavior, hyperactivity, and attention deficit disorder in Sydenham chorea. Neurology. 2005;64(10):1799–1801.Google Scholar
Hounie, AG, Pauls, DL, do Rosario-Campos, MC, et al. Obsessive-compulsive spectrum disorders and rheumatic fever: a family study. Biol Psychiatry. 2007;61(3):266–272.Google Scholar
Seixas, AA, Hounie, AG, Fossaluza, V, et al. Anxiety disorders and rheumatic fever: is there an association? CNS Spectr. 2008;13(12):1039–1046.Google Scholar
Ramasawmy, R, Fae, KC, Spina, G, et al. Association of polymorphisms within the promoter region of the tumor necrosis factor-alpha with clinical outcomes of rheumatic fever. Mol Immunol. 2007;44(8):1873–1878.Google Scholar
Hounie, AG, Cappi, C, Cordeiro, Q, et al. TNF-alpha polymorphisms are associated with obsessive-compulsive disorder. Neurosci Lett. 2008;442(2):86–90.Google Scholar
Swedo, SE, Leonard, HL, Rapoport, JL. The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) subgroup: separating fact from fiction. Pediatrics. 2004;113(4):907–911.Google Scholar
Snider, LA, Sachdev, V, Mackaronis, JE, St Peter, M, Swedo, SE. Echocardiographic findings in the PANDAS subgroup. Pediatrics. 2004;114(6): e748–e751.Google Scholar
Singer, HS, Hong, JJ, Yoon, DY, Williams, PN. Serum autoantibodies do not differentiate PANDAS and Tourette syndrome from controls. Neurology. 2005;65(11):1701–1707.Google Scholar
Brilot, F, Merheb, V, Ding, A, Murphy, T, Dale, RC. Antibody binding to neuronal surface in Sydenham chorea, but not in PANDAS or Tourette syndrome. Neurology. 2011;76(17):1508–1513.Google Scholar
Morris, CM, Pardo-Villamizar, C, Gause, CD, Singer, HS. Serum autoantibodies measured by immunofluorescence confirm a failure to differentiate PANDAS and Tourette syndrome from controls. J Neurol Sci. 2009;276(1–2):45–48.Google Scholar
Kurlan, R, Johnson, D, Kaplan, EL. Tourette Syndrome Study G. Streptococcal infection and exacerbations of childhood tics and obsessive-compulsive symptoms: a prospective blinded cohort study. Pediatrics. 2008;121(6):1188–1197.Google Scholar
Leckman, JF, King, RA, Gilbert, DL, et al. Streptococcal upper respiratory tract infections and exacerbations of tic and obsessive-compulsive symptoms: a prospective longitudinal study. J Am Acad Child Adolesc Psychiatry. 2011;50(2):108–118.e3.Google Scholar
Singer, HS, Gilbert, DL, Wolf, DS, Mink, JW, Kurlan, R. Moving from PANDAS to CANS. J Pediatr. 2012;160(5):725–731.Google Scholar
Williams, KA, Swedo, SE, Farmer, CA, et al. Randomized, controlled trial of intravenous immunoglobulin for pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections. J Am Acad Child Adolesc Psychiatry. 2016;55(10):860–867.e2.Google Scholar
Swedo, SE, Seidlitz, J, Kovacevic, M, et al. Clinical presentation of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections in research and community settings. J Child Adolesc Psychopharmacol. 2015;25(1):26–30.Google Scholar
Chang, K, Frankovich, J, Cooperstock, M, et al. Clinical evaluation of youth with pediatric acute-onset neuropsychiatric syndrome (PANS): recommendations from the 2013 PANS Consensus Conference. J Child Adolesc Psychopharmacol. 2015;25(1):3–13.Google Scholar
de Barros, JL, Barbosa, IG, Salem, H, et al. Is there any association between Toxoplasma gondii infection and bipolar disorder? A systematic review and meta-analysis. J Affect Disord. 2017;209:59–65.Google Scholar
Miman, O, Mutlu, EA, Ozcan, O, Atambay, M, Karlidag, R, Unal, S. Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder? Psychiatry Res. 2010;177(1–2):263–265.Google Scholar
Flegr, J, Horacek, J. Toxoplasma-infected subjects report an obsessive-compulsive disorder diagnosis more often and score higher in obsessive-compulsive inventory. Eur Psychiatry. 2017;40:82–87.Google Scholar
Perez-Vigil, A, Fernandez de la Cruz, L, Brander, G, Isomura, K, Gromark, C, Mataix-Cols, D. The link between autoimmune diseases and obsessive-compulsive and tic disorders: a systematic review. Neurosci Biobehav Rev. 2016;71:542–562.Google Scholar
Gray, SM, Bloch, MH. Systematic review of proinflammatory cytokines in obsessive-compulsive disorder. Curr Psychiatry Rep. 2012;14(3):220–228.Google Scholar
Simsek, S, Yuksel, T, Cim, A, Kaya, S. Serum cytokine profiles of children with obsessive-compulsive disorder shows the evidence of autoimmunity. Int J Neuropsychopharmacol. 2016;19(8):pii: pyw027.Google Scholar
Mitchell, RH, Goldstein, BI. Inflammation in children and adolescents with neuropsychiatric disorders: a systematic review. J Am Acad Child Adolesc Psychiatry. 2014;53(3):274–296.Google Scholar
Fontenelle, LF, Barbosa, IG, Luna, JV, de Sousa, LP, Abreu, MN, Teixeira, AL. A cytokine study of adult patients with obsessive-compulsive disorder. Compr Psychiatry. 2012;53(6):797–804.Google Scholar
Carpenter, LL, Heninger, GR, McDougle, CJ, Tyrka, AR, Epperson, CN, Price, LH. Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania. Psychiatry Res. 2002;112(3):257–262.Google Scholar
Mittleman, BB, Castellanos, FX, Jacobsen, LK, Rapoport, JL, Swedo, SE, Shearer, GM. Cerebrospinal fluid cytokines in pediatric neuropsychiatric disease. J Immunol. 1997;159(6):2994–2999.Google Scholar
Marazziti, D, Presta, S, Pfanner, C, et al. Immunological alterations in adult obsessive-compulsive disorder. Biol Psychiatry. 1999;46(6):810–814.Google Scholar
Marazziti, D, Mungai, F, Masala, I, et al. Normalisation of immune cell imbalance after pharmacological treatments of patients suffering from obsessive-compulsive disorder. J Psychopharmacol. 2009;23(5):567–573.Google Scholar
da Rocha, FF, Correa, H, Teixeira, AL. Obsessive-compulsive disorder and immunology: a review. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(5):1139–1146.Google Scholar
Maina, G, Albert, U, Bogetto, F, et al. Anti-brain antibodies in adult patients with obsessive-compulsive disorder. J Affect Disord. 2009;116(3):192–200.Google Scholar
Nicholson, TR, Ferdinando, S, Krishnaiah, RB, et al. Prevalence of anti-basal ganglia antibodies in adult obsessive-compulsive disorder: cross-sectional study. Br J Psychiatry. 2012;200(5):381–386.Google Scholar
Pearlman, DM, Vora, HS, Marquis, BG, Najjar, S, Dudley, LA. Anti-basal ganglia antibodies in primary obsessive-compulsive disorder: systematic review and meta-analysis. Br J Psychiatry. 2014;205(1):8–16.Google Scholar
Bhattacharyya, S, Khanna, S, Chakrabarty, K, Mahadevan, A, Christopher, R, Shankar, SK. Anti-brain autoantibodies and altered excitatory neurotransmitters in obsessive-compulsive disorder. Neuropsychopharmacology. 2009;34(12):2489–2496.Google Scholar
Frick, L, Pittenger, C. Microglial dysregulation in OCD, Tourette syndrome, and PANDAS. J Immunol Res. 2016;2016:8606057.Google Scholar
Kumar, A, Williams, MT, Chugani, HT. Evaluation of basal ganglia and thalamic inflammation in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection and Tourette syndrome: a positron emission tomographic (PET) study using 11C-[R]-PK11195. J Child Neurol. 2015;30(6):749–756.Google Scholar
Attwells, S, Setiawan, E, Wilson, AA, et al. Inflammation in the neurocircuitry of obsessive-compulsive disorder. JAMA Psychiatry. 2017;74(8):833–840.Google Scholar
Lennington, JB, Coppola, G, Kataoka-Sasaki, Y, et al. Transcriptome analysis of the human striatum in Tourette syndrome. Biol Psychiatry. 2016;79(5):372–382.Google Scholar
Ebrahimi Taj, F, Noorbakhsh, S, Ghavidel Darestani, S, Shirazi, E, Javadinia, S. Group A beta-hemolytic streptococcal infection in children and the resultant neuro-psychiatric disorder; a cross sectional study; Tehran, Iran. Basic Clin Neurosci. 2015;6(1):38–43.Google Scholar
Oglodek, EA, Szota, AM, Just, MJ, Mos, DM, Araszkiewicz, A. The MCP-1, CCL-5 and SDF-1 chemokines as pro-inflammatory markers in generalized anxiety disorder and personality disorders. Pharmacol Rep. 2015;67(1):85–89.Google Scholar
Kawikova, I, Leckman, JF, Kronig, H, et al. Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: a preliminary study. Biol Psychiatry. 2007;61(3):273–278.Google Scholar
Leckman, JF, Katsovich, L, Kawikova, I, et al. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette’s syndrome. Biol Psychiatry. 2005;57(6):667–673.Google Scholar
Gabbay, V, Coffey, BJ, Guttman, LE, et al. A cytokine study in children and adolescents with Tourette’s disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(6):967–971.Google Scholar
Bos-Veneman, NG, Bijzet, J, Limburg, PC, Minderaa, RB, Kallenberg, CG, Hoekstra, PJ. Cytokines and soluble adhesion molecules in children and adolescents with a tic disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(8):1390–1395.Google Scholar
Perlmutter, SJ, Leitman, SF, Garvey, MA, et al. Therapeutic plasma exchange and intravenous immunoglobulin for obsessive-compulsive disorder and tic disorders in childhood. Lancet. 1999;354(9185):1153–1158.Google Scholar
Murphy, TK, Brennan, EM, Johnco, C, et al. A double-blind randomized placebo-controlled pilot study of azithromycin in youth with acute-onset obsessive-compulsive disorder. J Child Adolesc Psychopharmacol. 2017;27(7):640–651.Google Scholar
Murphy, TK, Parker-Athill, EC, Lewin, AB, Storch, EA, Mutch, PJ. Cefdinir for recent-onset pediatric neuropsychiatric disorders: a pilot randomized trial. J Child Adolesc Psychopharmacol. 2015;25(1):57–64.Google Scholar
Muller, N. Anti-inflammatory therapy with a COX-2 inhibitor in Tourette’s syndrome. Inflammopharmacology. 2004;12(3):271–275.Google Scholar
Brown, K, Farmer, C, Farhadian, B, Hernandez, J, Thienemann, M, Frankovich, J. Pediatric acute-onset neuropsychiatric syndrome response to oral corticosteroid bursts: an observational study of patients in an academic community-based PANS clinic. J Child Adolesc Psychopharmacol. 2017;27(7):629–639.Google Scholar
Barash, J, Margalith, D, Matitiau, A. Corticosteroid treatment in patients with Sydenham’s chorea. Pediatr Neurol. 2005;32(3):205–207.Google Scholar
Paz, JA, Silva, CA, Marques-Dias, MJ. Randomized double-blind study with prednisone in Sydenham’s chorea. Pediatr Neurol. 2006;34(4):264–269.Google Scholar
Walker, AR, Tani, LY, Thompson, JA, Firth, SD, Veasy, LG, Bale, JF, Jr. Rheumatic chorea: relationship to systemic manifestations and response to corticosteroids. J Pediatr. 2007;151(6):679–683.Google Scholar
Brown, KD, Farmer, C, Freeman, GM, Jr, et al. Effect of early and prophylactic nonsteroidal anti-inflammatory drugs on flare duration in pediatric acute-onset neuropsychiatric syndrome: an observational study of patients followed by an academic community-based pediatric acute-onset neuropsychiatric syndrome clinic. J Child Adolesc Psychopharmacol. 2017;27(7):619–628.Google Scholar
Grant, JE. Clinical practice: obsessive-compulsive disorder. N Engl J Med. 2014;371(7):646–653.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×