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Depression is associated with lower circulating endothelial progenitor cells and increased inflammatory markers

Published online by Cambridge University Press:  24 June 2014

Lu Yang ,
Lie-Min Ruan ,
Hong-Hua Ye ,
Han-Bin Cui ,
Qi-Tian Mu ,
Yan-Ru Lou ,
Yun-Xin Ji ,
Wan-Zhen Li ,
Ding-He Sun  and
Xiao-Bei Chen
Lu Yang
Affiliation:
Department of Psychology, Ningbo First Hospital, Ningbo, Zhejiang, China
Lie-Min Ruan*
Affiliation:
Department of Psychology, Ningbo First Hospital, Ningbo, Zhejiang, China
Hong-Hua Ye
Affiliation:
Department of Cardiology, Ningbo First Hospital, Ningbo, Zhejiang, China
Han-Bin Cui
Affiliation:
Department of Cardiology, Ningbo First Hospital, Ningbo, Zhejiang, China
Qi-Tian Mu
Affiliation:
The Stem Cells Transplantation Center, Ningbo First Hospital, Ningbo, Zhejiang, China
Yan-Ru Lou
Affiliation:
The Stem Cells Transplantation Center, Ningbo First Hospital, Ningbo, Zhejiang, China
Yun-Xin Ji
Affiliation:
Department of Psychology, Ningbo First Hospital, Ningbo, Zhejiang, China
Wan-Zhen Li
Affiliation:
Department of Psychology, Ningbo First Hospital, Ningbo, Zhejiang, China
Ding-He Sun
Affiliation:
The Stem Cells Transplantation Center, Ningbo First Hospital, Ningbo, Zhejiang, China
Xiao-Bei Chen
Affiliation:
The Stem Cells Transplantation Center, Ningbo First Hospital, Ningbo, Zhejiang, China
*
Professor Lie-Min Ruan, Department of Psychology, Ningbo First Hospital, Ningbo, Zhejiang 315010, China. Tel: 86 574 87085588; Fax: 86 1354787662; E-mail: liemin_ruan@163.com
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Extract

Yang L, Ruan L-M, Ye H-H, Cui H-B, Mu Q-T, Lou Y-R, Ji Y-X, Li W-Z, Sun D-H, Chen X-B. Depression is associated with lower circulating endothelial progenitor cells and increased inflammatory markers.

Objective: To test the hypothesis that depression status in subjects without cardiovascular diseases (CVD) or diabetes is associated with depletion of circulating endothelial progenitor cells (EPCs) and impaired endothelial function.

Method: Thirty depressive persons with the first episode of depression (case group) diagnosed according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) and 30 healthy people (control group) were investigated. The depression status was estimated using Hamilton Rating Scale of Depression from which the criteria of depression are determined to be >21 score. EPCs labeled with CD34-ECD, CD133-phycoerythrin and kinase insert domain receptor (KDR)-fluorescein isothiocyanate antibodies were counted by flow cytometry in the peripheral blood of patients and control subjects. Mononuclear cells that were positive for CD34/KDR, CD133/KDR and CD34/CD133/KDR within the lymphocyte population were characterised as different phenotypes of EPCs.

Results: There were no significant differences in baseline clinical characteristics between patients and healthy individuals (all p > 0.05). However, patients with depression had significantly lower levels of circulating CD34+CD133+KDR+ EPCs (132.20 ± 17.27 vs. 225.93 ± 9.88, p = 0.000) and endothelial colony-forming units (26.40 ± 3.79 vs. 36.60 ± 2.88, p = 0.000) than that of healthy subjects. Furthermore, CD34+CD133+KDR+ EPCs had a negative correlation with tumour necrosis factor-α (Spearman's ρ = 0.433, p = 0.000) and interleukin-6 (Spearman's ρ = 0.441, p = 0.032).

Conclusion: Our result shows that depression was associated with lower levels of circulating EPCs, which may contribute to the development of endothelial dysfunction and atherosclerosis.

Keywords

cardiovascular diseasedepressionendothelial progenitor cellshigh-sensitive C-reactive proteininterleukin-6tumour necrosis factor-α
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 23 , Issue 5 , October 2011 , pp. 235 - 240
Copyright
Copyright © Cambridge University Press 2011

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References

1. Rihmer, Z, Angst, J. Mood disorders: epidemiology. In: Sadock, BJ, Sadock, VA, eds. Kaplan & Sadock's comprehensive textbook of psychiatry, 8th edn. Philadelphia: Lippincott Williams & Wilkins, 2005: 1576–1582. Google Scholar
2. Heather, SL, James, AB, Michael, AB et al. Depression as a risk factor for coronary artery disease: evidence, mechanisms, and treatment. Psychosom Med 2004;66:305–315. Google Scholar
3. Charlton, BG, Leake, A, Wright, C, Griffiths, HW, Ferrier, IN. A combined study of cortisol, ACTH and dexamethasone concentrations in major depression. Multiple time-point sampling. Br J Psychiatry 1987;150:791–796. CrossRefGoogle ScholarPubMed
4. Carmine, P, Lamberto, M, Stefano, M, Grazia, MC. Analysis of potential predictors of depression among coronary heart disease risk factors including heart rate variability, markers of inflammation, and endothelial function. Eur Heart J 2008;29:1110–1117.Google Scholar
5. Erica, CB, Dominique, LM. Depression, alterations in platelet function, and ischemic heart disease. Psychosom Med 2005;67:S34–S36. Google Scholar
6. Empana, JP, Sykes, DH, Luc, G et al. Contributions of depressive mood and circulating inflammatory markers to coronary heart disease in healthy European men: the prospective epidemiological study of myocardial infarction (PRIME). Circulation 2005;111:2299–2305. Google Scholar
7. Ladwig, KH, Birgitt, MM, Hannelore, L, Angela, D, Wolfgang, K. C-reactive protein, depressed mood, and the prediction of coronary heart disease in initially healthy men: results from the MONICA-KORA Augsburg Cohort Study 1984–98. Eur Heart J 2005;26:2537–2542. Google Scholar
8. Sanjay, R, Robert, B, Melvyn, R, Elaine, P, Elizabeth, Y, Bertram, P. Abnormal brachial artery flow-mediated vasodilation in young adults with major depression. Am J Cardiol 2001;88:196–198. Google Scholar
9. Lett, HS, Blumenthal, JA, Babyak, MA, Sherwood, A, Strauman, T, Robins, C. Depression as a risk factor for coronary artery disease: evidence, mechanisms, and treatment. Psychosom Med 2004;66:305–315. Google ScholarPubMed
10. Aaron, L, Frank, B, Timothy, OB. Endothelial progenitor cells: diagnostic and therapeutic considerations. Bioessays 2006;28:261–270. Google Scholar
11. Gian, PF, Anna, C, Ilenia, B et al. Peripheral blood CD34+KDR+ endothelial progenitor cells are determinants of subclinical atherosclerosis in a middle-aged general population. Stroke 2006;37:2277–2282. Google Scholar
12. Jonathan, MH, Gloria, Z, Julian, PJ et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003;348:593–600. Google Scholar
13. Imanishi, T, Moriwaki, C, Hano, T, Nishio, I. Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients with essential hypertension. J Hypertens 2005;23:1831–1837. Google Scholar
14. Nikos, W, Sonja, K, Tobias, S et al. Circulating endothelial progenitor cells and cardiovascular outcomes. N Engl J Med 2005;53:999–1007. Google Scholar
15. Loomans, CJM, De Koning, EJP, Staal, FJT et al. Endothelial progenitor cell dysfunction: a novel concept in the pathogenesis of vascular complications of type 1 diabetes. Diabetes 2004;53:195–299. CrossRefGoogle ScholarPubMed
16. Chen, JZ, Zhang, FR, Tao, QM, Wang, XX, Zhu, JH, Zhu, JH. Number and activity of endothelial progenitor cells from peripheral blood in patients with hyper- cholesterolaemia. Clin Sci (Lond) 2004;10:273–280. Google Scholar
17. Kay, H, Frank, P, Sarah, F, Peter, G. Endothelial progenitor cells in chronic renal insufficiency. Kidney Blood Press Res 2006;29:24–31. Google Scholar
18. Johannes, G, Daniel, A, Carl, WS et al. Depletion of endothelial progenitor cells in the peripheral blood of patients with rheumatoid arthritis. Circulation 2005;111:204–211. Google Scholar
19. Michaud, SE, Dussault, S, Haddad, P, Groleau, J, Rivard, A. Circulating endothelial progenitor cells from healthy smokers exhibit impaired functional activities. Atherosclerosis 2006;187:423–432. CrossRefGoogle ScholarPubMed
20. Dirk, H, Walter Kilian, R et al. Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells. Circulation 2002;105:3017–3024. Google Scholar
21. Jalees, R, Jingling, L, Lakshmi, P et al. Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells. J Am Coll Cardiol 2004;4:2314–2318. Google Scholar
22. Kerstin, S, Nikos, W, Jan, B et al. Estrogen increases bone marrow-derived endothelial progenitor cell production and diminishes neointima formation. Circulation 2003;107:3059–3065. Google Scholar
23. Kilpatrick, JM, Volanakis, JE. Molecular genetics, structure, and function of C-reactive protein. Immunol Res 1991; 10:43–53. Google Scholar
24. Subodh, V, Wang, CH, Li, SH et al. A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis. Circulation 2002;106:913–919. Google Scholar
25. Joseph, AV, John, FK, Martin, JG et al. Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study. Circulation 2004;110:3604– 3609. Google Scholar
26. Florian, HS, Judith, H, Dirk, H et al. Mitogen-activated protein kinase downregulates endothelial progenitor cells. Circulation 2005;111:1184–1191. Google Scholar