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Perseveration in schizophrenic patients: a neuropsychological approach for research

Published online by Cambridge University Press:  18 September 2015

M.G. Lanser ,
B.A. Ellenbroek ,
A.R. Cools  and
F.G. Zitman
M.G. Lanser*
Affiliation:
Department of Psychoneuropharmacology, Katholieke Universiteit Nijmegen
B.A. Ellenbroek
Affiliation:
Department of Psychoneuropharmacology, Katholieke Universiteit Nijmegen
A.R. Cools
Affiliation:
Department of Psychoneuropharmacology, Katholieke Universiteit Nijmegen
F.G. Zitman
Affiliation:
Department of Psychiatry, St. Radboud Ziekenhuis, Nijmegen
*
Department of Psychoneuropharmacology, Katholieke Universiteit Nijmegen, Postbus 9101, 6500 HB Nijmegen, The Netherlands
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Summary

Perseveration is a core symptom of schizophrenia, the cause, however, is unknown. It has been shown that for people with frontal lobe lesions, perseveration can be explained with a set-maintenance problem. Perseveration in Parkinson's disease can be explained with problems shifting from one set to another without cues (set-shifting). These disorders can be distinguished using a two-choice task and the Wisconsin Card Sorting Test, that is analysed in phases. Analogs of these tests can be used in animal research. By adding an animal part to the human research, more insight can be gained into the role of specific brain areas in set-maintenance and set-shifting.

Keywords

schizophreniaperseverationWisconsin Card sorting Testtwo-choice taskset-maintenanceset-shifting
Type
Articles
Information
Acta Neuropsychiatrica , Volume 12 , Issue 1 , March 2000 , pp. 27 - 31
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2000

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