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Epigenetic alterations related to early-life stressful events

Published online by Cambridge University Press:  24 June 2014

Raúl Ventura-Junca  and
Luisa M. Herrera
Raúl Ventura-Junca
Affiliation:
School of Psychology, Universidad de los Andes, Santiago, Chile Human Genetics Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago, Chile
Luisa M. Herrera*
Affiliation:
Human Genetics Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago, Chile
*
Luisa Herrera, Programa de Genética Humana, ICBM, Facultad de Medicina, Universidad de Chile, Independencia 1027, Independencia, Santiago, Chile. Tel: 562 9786976; Fax: 562 7373158; E-mail: lherrera@med.uchile.cl
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Extract

Objective: Early stress events severely impact brain and behaviour. From a neurobiological point of view early stress influences neuroanatomical structures and is associated with a dysregulation of the hypothalamic-pituitary-adrenal axis. The objective of this article is to review the epigenetic alterations implicated in brain adaptation to early stress events.

Method: A review of empirical research of epigenetic alterations associated to early stress events was performed.

Results: Neuroanatomic and epigenetic alterations have been observed after early stress events. Epigenetics alterations include DNA methylation, histones modifications and microRNA (miRNA) expression. The most studied is largely the former, affecting genes involved in neuroendocrine, neurotransmission and neuroplasticity regulation after early stress exposition. It includes glucocorticoid receptor, FK506-binding protein 5, arginine vasopressin, oestrogen receptor alpha, 5-hydroxy-tryptamine transporter and brain-derived neurotrophic factor.

Conclusion: Epigenetic regulation is critical in the interplay between nature and nurture. Alterations in the DNA methylation as well as histones modifications and miRNA expression patterns could explain abnormal behaviours secondary to early stress events.

Keywords

behaviourearly stressepigeneticHPAmethylation
Type
Review Article
Information
Acta Neuropsychiatrica , Volume 24 , Issue 5 , October 2012 , pp. 255 - 265
Copyright
Copyright © Cambridge University Press 2012

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