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Functional brain imaging, sleep, and sleep deprivation: contributions to the “overarousal” hypothesis of depression

Published online by Cambridge University Press:  18 September 2015

J.C. Gillin ,
A.P. Ho ,
M.S. Buchsbaum ,
J. Wu ,
L. Abel  and
W.E. Bunney Jr
J.C. Gillin*
Affiliation:
University of California, San Diego and San Diego VA Medical Center
A.P. Ho
Affiliation:
University of California, San Diego and San Diego VA Medical Center
M.S. Buchsbaum
Affiliation:
Mt. Sinai School of Medicine
J. Wu
Affiliation:
University of California. Irvine
L. Abel
Affiliation:
University of California. Irvine
W.E. Bunney Jr
Affiliation:
University of California. Irvine
*
Dept. of Psychiatry (0603), University of California, San Diego, VA Medical Center, 9500 Gilman Drive, La Jolla CA 92093-0603, USA
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Extract

In 1975 van den Burg and van den Hoofdakker hypothesized that depressed patients might be ‘overaroused.’ This suggestion is consistent not only with their seminal observations on the antidepressant effects of total sleep deprivation in depression, but with the short, fragmented, and shallow sleep of depressed patients, lowered arousal thresholds, hyperactivity of the hypothalamus-pituitary adrenal (HPA) axis, and elevated core body temperature commonly found in some patients during the sleep period.

Keywords

sleep deprivationdepressioncerebral glucose consumptionpositron emission tomographyslaapdeprivatiedepressiecerebraal glucose verbruikpositron emissie tomografie
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 7 , Issue 2 , June 1995 , pp. 33 - 34
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1995

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References

Literature

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