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Na+,K+-ATPase activity is increased in rats subjected to chronic administration of ketamine

Published online by Cambridge University Press:  24 June 2014

Renata D. De Luca ,
Daiane de B. Fraga ,
Fernando V. Ghedim ,
Janaína Kolling ,
Andrea G. K. Ferreira ,
Aline A. Cunha ,
Angela T. S. Wyse  and
Alexandra I. Zugno
Renata D. De Luca
Affiliation:
Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, SC, Brazil
Daiane de B. Fraga
Affiliation:
Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, SC, Brazil
Fernando V. Ghedim
Affiliation:
Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, SC, Brazil
Janaína Kolling
Affiliation:
Laboratório de Erros Inatos do Metabolismo, Programa de Pós-Graduação em Ciências Biológicas – Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
Andrea G. K. Ferreira
Affiliation:
Laboratório de Erros Inatos do Metabolismo, Programa de Pós-Graduação em Ciências Biológicas – Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
Aline A. Cunha
Affiliation:
Laboratório de Erros Inatos do Metabolismo, Programa de Pós-Graduação em Ciências Biológicas – Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
Angela T. S. Wyse
Affiliation:
Laboratório de Erros Inatos do Metabolismo, Programa de Pós-Graduação em Ciências Biológicas – Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
Alexandra I. Zugno*
Affiliation:
Laboratório de Neurociências and Instituto Nacional de Ciência e Tecnologia Translacional em Medicina (INCT-TM), Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000, Criciúma, SC, Brazil
*
Professor Alexandra Ioppi Zugno, Laboratório de Neurociências, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-000 Criciúma, SC, Brazil. Tel: +55 48 3431 2792; Fax: +55 48 3431 2759; E-mail: zugno@terra.com.br
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Extract

De Luca RD, Fraga DB, Ghedim FV, Kolling J, Ferreira AGK, Cunha AA, Wyse ATS, Zugno AI. Na+,K+-ATPase activity is increased in rats subjected to chronic administration of ketamine.

Objective: Schizophrenia is a devastating psychiatric disorder. Symptoms of schizophrenia can be divided into positive, negative and cognitive, and the physiopathology is still been unknown. Na+,K+-ATPase is a protein in its role as a maintainer of fluid balance in all mammals and alterations in this enzyme could cause brain abnormalities. The aim of our study was to investigate the activity of this enzyme in rats submitted to chronic administration of ketamine.

Methods: Adult male Wistar rats were submitted to sub-anaesthetic doses of the 25 mg/kg ketamine by seven consecutive days and the Na+,K+-ATPase activity was analysed in prefrontal and hippocampus of rats.

Results: We observed an increase in Na+,K+-ATPase activity in prefrontal cortex administration of 25 mg/kg ketamine. However, ketamine has no effect in hippocampus.

Conclusion: This evidence indicates that the alteration in Na+,K+-ATPase may be related with glutamatergic system and consequently could be related to the development of schizophrenia.

Keywords

Na+,K+-ATPasehippocampusprefrontal cortexschizophrenia
Type
Rapid Communications
Information
Acta Neuropsychiatrica , Volume 23 , Issue 5 , October 2011 , pp. 215 - 218
Copyright
Copyright © Cambridge University Press 2011

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