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Oxytocin in schizophrenia: a review of evidence for its therapeutic effects

Published online by Cambridge University Press:  24 June 2014

Kai MacDonald  and
David Feifel
Kai MacDonald*
Affiliation:
Department of Psychiatry, San Diego Medical Center, University of California, San Diego, CA, USA
David Feifel
Affiliation:
Department of Psychiatry, San Diego Medical Center, University of California, San Diego, CA, USA
*
Dr Kaimana MacDonald, Department of Psychiatry, San Diego Medical Center, University of California, San Diego, CA, USA. Tel: +619 543 2827; Fax: +619 543 3799; E-mail: kai@kaimacdonald.com
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Extract

Background: The suggestion that the neurohormone oxytocin may have clinical application in the treatment of schizophrenia was first published in 1972. Since then, a considerable body of research on a variety of fronts – including several recent double-blind treatment trials – has buttressed these early reports, providing support for the assertion that the oxytocin system is a promising and novel therapeutic target for this devastating malady. Herein, we review the diverse, convergent lines of evidence supporting the therapeutic potential of oxytocin in psychotic illness.

Methods: We performed a systematic review of preclinical and clinical literature pertaining to oxytocin's role in schizophrenia.

Results: Multiple lines of evidence converge to support the antipsychotic potential of oxytocin. These include several animal models of schizophrenia, pharmacological studies examining the impact of antipsychotics on the oxytocin system, human trials in patients examining the aspects of the oxytocin system and several double-blind, placebo-controlled clinical treatment trials.

Conclusions: There exists considerable, convergent evidence that oxytocin has potential as a novel antipsychotic with a unique mechanism of action. Auspiciously, based on the few chronic trials to date, its safety profile and tolerability appear very good. That said, several critical clinical questions await investigation before widespread use is clinically warranted.

Keywords

brain/physiologydouble-blind methodhumansintranasaloxytocin/administration and dosageschizophreniasocial perception

Information

Type
Review article
Information
Acta Neuropsychiatrica , Volume 24 , Issue 3 , June 2012 , pp. 130 - 146
Copyright
Copyright © Cambridge University Press 2011

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References

1.Van Os, J, Kapur, S.Schizophrenia. Lancet 2009; 374: 635–645.CrossRefGoogle ScholarPubMed
2.Keshavan, MS, Nasrallah, HA, Tandon, R.Schizophrenia, “Just the Facts” 6. Moving ahead with the schizophrenia concept: from the elephant to the mouse. Schizophr Res 2011; 127: 3–13.Google Scholar
3.Meyer-Lindenberg, A.From maps to mechanisms through neuroimaging of schizophrenia. Nature 2010; 468: 194–202.Google Scholar
4.Guo, X, Zhai, J, Liu, Z et al. Effect of antipsychotic medication alone vs combined with psychosocial intervention on outcomes of early-stage schizophrenia: a randomized, 1-year study. Arch Gen Psychiatry 2010; 67: 895–904.CrossRefGoogle ScholarPubMed
5.Leucht, C, Heres, S, Kane, JM, Kissling, W, Davis, JM, Leucht, S.Oral versus depot antipsychotic drugs for schizophrenia –a critical systematic review and meta-analysis of randomised long-term trials. Schizophr Res 2011; 127: 83–92.CrossRefGoogle ScholarPubMed
6.Agid, O, Mamo, D, Ginovart, N et al. Striatal vs extrastriatal dopamine D2 receptors in antipsychotic response –a double-blind PET study in schizophrenia. Neuropsychopharmacology 2007; 32: 1209–1215.CrossRefGoogle ScholarPubMed
7.Dziedzicka-Wasylewska, M, Faron-Gorecka, A, Gorecki, A, Kusemider, M.Mechanism of action of clozapine in the context of dopamine D1-D2 receptor hetero-dimerization –a working hypothesis. Pharmacol Rep 2008; 60: 581–587.Google ScholarPubMed
8.Nord, M, Farde, L.Antipsychotic occupancy of dopamine receptors in schizophrenia. CNS Neurosci Ther 2011; 17: 97–103.Google Scholar
9.Bujanow, W.Hormones in the treatment of psychoses. Br Med J 1972; 4: 298.CrossRefGoogle ScholarPubMed
10.Kimura, T, Tanizawa, O, Mori, K, Brownstein, MJ, Okayama, H.Structure and expression of a human oxytocin receptor. Nature 1992; 356: 526–529.Google Scholar
11.Ivell, R, Richter, D.Structure and comparison of the oxytocin and vasopressin genes from rat. Proc Natl Acad Sci U S A 1984; 81: 2006–2010.Google Scholar
12.Feifel, D, Macdonald, K, Nguyen, A et al. Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients. Biol Psychiatry 2010; 68: 678–680.CrossRefGoogle ScholarPubMed
13.Pedersen, CA, Gibson, CM, Rau, SW et al. Intranasal oxytocin reduces psychotic symptoms and improves Theory of Mind and social perception in schizophrenia. Schizophr Res 2011; 132: 50–53.Google Scholar
14.Donaldson, ZR, Young, LJ.Oxytocin, vasopressin, and the neurogenetics of sociality. Science 2008; 322: 900–904.Google Scholar
15.Gimpl, G, Fahrenholz, F.The oxytocin receptor system: structure, function, and regulation. Physiol Rev 2001; 81: 629–683.Google Scholar
16.Madden, JR, Clutton-Brock, TH.Experimental peripheral administration of oxytocin elevates a suite of cooperative behaviours in a wild social mammal. Proc Biol Sci 2011; 278: 1189–1194.Google Scholar
17.Goodson, JL, Schrock, SE, Klatt, JD, Kabelik, D, Kingsbury, MA.Mesotocin and nonapeptide receptors promote estrildid flocking behavior. Science 2009; 325: 862–866.CrossRefGoogle ScholarPubMed
18.Oldfield, RG, Hofmann, HA.Neuropeptide regulation of social behavior in a monogamous cichlid fish. Physiol Behav 2011; 102: 296–303.CrossRefGoogle Scholar
19.Wagenaar, DA, Hamilton, MS, Huang, T, Kristan, WB, French, KA.A hormone-activated central pattern generator for courtship. Curr Biol 2010; 20: 487–495.CrossRefGoogle ScholarPubMed
20.Sala, M, Braida, D, Lentini, D et al. Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: a neurobehavioral model of autism. Biol Psychiatry 2011; 69: 875–882.CrossRefGoogle ScholarPubMed
21.Schorscher-Petcu, A, Sotocinal, S, Ciura, S et al. Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse. J Neurosci, 2010; 30: 8274–8284.CrossRefGoogle ScholarPubMed
22.Seifer, DB, Sandberg, EC, Ueland, K, Sladen, RN.Water intoxication and hyponatremic encephalopathy from the use of an oxytocin nasal spray. A case report. J Reprod Med 1985; 30: 225–228.Google ScholarPubMed
23.Stratton, JF, Stronge, J, Boylan, PC.Hyponatraemia and non-electrolyte solutions in labouring primigravida. Eur J Obstet Gynecol Reprod Biol 1995; 59: 149–151.CrossRefGoogle ScholarPubMed
24.Li, C, Wang, W, Summer, SN et al. Molecular mechanisms of antidiuretic effect of oxytocin. J Am Soc Nephrol 2008; 19: 225–232.Google Scholar
25.Liggins, GC.Antidiuretic effects of oxytocin, morphine and pethidine in pregnancy and labour. Aust N Z J Obstet Gynaecol 1963; 3: 81–83.CrossRefGoogle ScholarPubMed
26.Carter, CS, Grippo, AJ, Pournajafi-Nazarloo, H, Ruscio, MG, Porges, SW.Oxytocin, vasopressin and sociality. Prog Brain Res 2008; 170: 331–336.CrossRefGoogle ScholarPubMed
27.Insel, TR.Oxytocin –a neuropeptide for affiliation: evidence from behavioral, receptor autoradiographic, and comparative studies. Psychoneuroendocrinology 1992; 17: 3–35.CrossRefGoogle ScholarPubMed
28.Insel, TR.The challenge of translation in social neuroscience: a review of oxytocin, vasopressin, and affiliative behavior. Neuron 2010; 65: 768–779.CrossRefGoogle ScholarPubMed
29.Landgraf, R, Neumann, ID.Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication. Front Neuroendocrinol 2004; 25: 150–176.CrossRefGoogle Scholar
30.Meyer-Lindenberg, A, Domes, G, Kirsch, P, Heinrichs, M.Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. Nat Rev Neurosci 2011; 12: 524–538.Google Scholar
31.Sogolow, SR.An historical review of the use of oxytocin prior to delivery. Obstet Gynecol Surv 1966; 21: 155–172.CrossRefGoogle ScholarPubMed
32.Uvnas-Moberg, K, Eriksson, M.Breastfeeding: physiological, endocrine and behavioural adaptations caused by oxytocin and local neurogenic activity in the nipple and mammary gland. Acta Paediatr 1996; 85: 525–530.CrossRefGoogle ScholarPubMed
33.Amico, JA, Challinor, SM, Cameron, JL.Pattern of oxytocin concentrations in the plasma and cerebrospinal fluid of lactating rhesus monkeys (Macaca mulatta): evidence for functionally independent oxytocinergic pathways in primates. J Clin Endocrinol Metab 1990; 71: 1531–1535.CrossRefGoogle ScholarPubMed
34.Amico, JA, Tenicela, R, Johnston, J, Robinson, AG.A time-dependent peak of oxytocin exists in cerebrospinal fluid but not in plasma of humans. J Clin Endocrinol Metab 1983; 57: 947–951.CrossRefGoogle Scholar
35.Neumann, ID.Stimuli and consequences of dendritic release of oxytocin within the brain. Biochem Soc Trans 2007; 35( Pt 5): 1252–1257.Google Scholar
36.Burri, A, Heinrichs, M, Schedlowski, M, Kruger, TH.The acute effects of intranasal oxytocin administration on endocrine and sexual function in males. Psychoneuroendocrinology 2008; 33: 591–600.CrossRefGoogle ScholarPubMed
37.Feldman, R, Gordon, I, Schneiderman, I, Weisman, O, Zagoory-Sharon, O.Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent-infant contact. Psychoneuroendocrinology 2010; 35: 1133–1141.Google Scholar
38.Light, KC, Smith, TE, Johns, JM, Brownley, KA, Hofheimer, JA, Amico, JA.Oxytocin responsivity in mothers of infants: a preliminary study of relationships with blood pressure during laboratory stress and normal ambulatory activity. Health Psychol 2000; 19: 560–567.CrossRefGoogle ScholarPubMed
39.Strathearn, L, Fonagy, P, Amico, J, Montague, PR.Adult attachment predicts maternal brain and oxytocin response to infant cues. Neuropsychopharmacology 2009; 34: 2655–2666.CrossRefGoogle ScholarPubMed
40.Veenema, AH, Neumann, ID.Central vasopressin and oxytocin release: regulation of complex social behaviours. Prog Brain Res 2008; 170: 261–276.Google Scholar
41.Veening, JG, de Jong, T, Barendregt, HP.Oxytocin-messages via the cerebrospinal fluid: behavioral effects; a review. Physiol Behav 2010; 101: 193–210.CrossRefGoogle ScholarPubMed
42.Goldman, M, Marlow-O'Connor, M, Torres, I, Carter, CS.Diminished plasma oxytocin in schizophrenic patients with neuroendocrine dysfunction and emotional deficits. Schizophr Res 2008; 98: 247–255.CrossRefGoogle ScholarPubMed
43.Rubin, LH, Carter, CS, Drogos, L et al. Sex-specific associations between peripheral oxytocin and emotion perception in schizophrenia. Schizophr Res 2011; 130: 266–270.CrossRefGoogle ScholarPubMed
44.Rubin, LH, Carter, CS, Drogos, L, Pournajafi- Nazarloo, H, Sweeney, JA, Maki, PM.Peripheral oxytocin is associated with reduced symptom severity in schizophrenia. Schizophr Res 2010; 124: 13–21.CrossRefGoogle ScholarPubMed
45.Gutkowska, J, Jankowski, M.Oxytocin revisited: it is also a cardiovascular hormone. J Am Soc Hyperten 2008; 2: 318–325.Google Scholar
46.Feldman, R, Gordon, I, Zagoory-Sharon, O.Maternal and paternal plasma, salivary, and urinary oxytocin and parent-infant synchrony: considering stress and affiliation components of human bonding. Dev Sci 2011; 14: 752–761.CrossRefGoogle ScholarPubMed
47.Ludwig, M, Leng, G.Dendritic peptide release and peptide-dependent behaviours. Nat Rev Neurosci 2006; 7: 126–136.Google Scholar
48.Buijs, RM, Van Heerikhuize, JJ.Vasopressin and oxytocin release in the brain –a synaptic event. Brain Res 1982; 252: 71–76.CrossRefGoogle Scholar
49.Sofroniew, MV, Weindl, A, Schrell, U, Wetzstein, R.Immunohistochemistry of vasopressin, oxytocin and neurophysin in the hypothalamus and extrahypothalamic regions of the human and primate brain. Acta Histochem Suppl 1981; 24: 79–95.Google ScholarPubMed
50.Baumgartner, T, Heinrichs, M, Vonlanthen, A, Fischbacher, U, Fehr, E.Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron 2008; 58: 639–650.Google Scholar
51.Domes, G, Heinrichs, M, Glascher, J, Buchel, C, Braus, DF, Herpertz, SC.Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Biol Psychiatry 2007; 62: 1187–1190.CrossRefGoogle ScholarPubMed
52.Domes, G, Lischke, A, Berger, C et al. Effects of intranasal oxytocin on emotional face processing in women. Psychoneuroendocrinology 2010; 35: 83–93.CrossRefGoogle ScholarPubMed
53.Gamer, M, Zurowski, B, Buchel, C.Different amygdala subregions mediate valence-related and attentional effects of oxytocin in humans. Proc Natl Acad Sci U S A 2010; 107: 9400–9405.CrossRefGoogle ScholarPubMed
54.Kirsch, P, Esslinger, C, Chen, Q et al. Oxytocin modulates neural circuitry for social cognition and fear in humans. J Neurosci 2005; 25: 11489–11493.Google Scholar
55.Petrovic, P, Kalisch, R, Singer, T, Dolan, RJ.Oxytocin attenuates affective evaluations of conditioned faces and amygdala activity. J Neurosci 2008; 28: 6607–6615.CrossRefGoogle ScholarPubMed
56.Riem, MM, Bakermans-Kranenburg, MJ, Pieper, S et al. Oxytocin modulates amygdala, insula, and inferior frontal gyrus responses to infant crying: a randomized controlled trial. Biol Psychiatry 2011; 70: 291–297.Google Scholar
57.Rilling, JK, Demarco, AC, Hackett, PD et al. Effects of intranasal oxytocin and vasopressin on cooperative behavior and associated brain activity in men. Psychoneuroendocrinology 2011 (in press).Google Scholar
58.McGregor, IS, Callaghan, PD, Hunt, GE.From ultrasocial to antisocial: a role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use? Br J Pharmacol 2008; 154: 358–368.CrossRefGoogle ScholarPubMed
59.Rosenfeld, AJ, Lieberman, JA, Jarskog, LF.Oxytocin, dopamine, and the amygdala: a neurofunctional model of social cognitive deficits in schizophrenia. Schizophr Bull 2011; 37: 1077–1087.CrossRefGoogle ScholarPubMed
60.de Bono, M.Molecular approaches to aggregation behavior and social attachment. J Neurobiol 2003; 54: 78–92.Google Scholar
61.Skuse, DH, Gallagher, L.Dopaminergic-neuropeptide interactions in the social brain. Trends Cogn Sci 2009; 13: 27–35.Google Scholar
62.Broad, KD, Levy, F, Evans, G, Kimura, T, Keverne, EB, Kendrick, KM.Previous maternal experience potentiates the effect of parturition on oxytocin receptor mRNA expression in the paraventricular nucleus. Eur J Neurosci 1999; 11: 3725–3737.Google Scholar
63.Loup, F, Tribollet, E, Dubois-Dauphin, M, Dreifuss, J J.Localization of high-affinity binding sites for oxytocin and vasopressin in the human brain. An autoradiographic study. Brain Res 1991; 555: 220–232.CrossRefGoogle Scholar
64.Loup, F, Tribollet, E, Dubois-Dauphin, M, Pizzolato, G, Dreifuss, JJ.Localization of oxytocin binding sites in the human brainstem and upper spinal cord: an autoradiographic study. Brain Res 1989; 500: 223–230.Google Scholar
65.Tribollet, E, Dubois-Dauphin, M, Dreifuss, JJ, Barberis, C, Jard, S.Oxytocin receptors in the central nervous system. Distribution, development, and species differences. Ann N Y Acad Sci 1992; 652: 29–38.CrossRefGoogle ScholarPubMed
66.Inoue, H, Yamasue, H, Tochigi, M et al. Association between the oxytocin receptor gene and amygdalar volume in healthy adults. Biol Psychiatry 2011; 68: 1066–1072.Google Scholar
67.Liu, X, Kawamura, Y, Shimada, T et al. Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population. J Hum Genet 2011; 55: 137–141.CrossRefGoogle Scholar
68.Montag, C, Fiebach, CJ, Kirsch, P, Reuter, M.Interaction of 5-HTTLPR and a variation on the oxytocin receptor gene influences negative emotionality. Biol Psychiatry 2011; 69: 601–603.CrossRefGoogle Scholar
69.Rodrigues, SM, Saslow, LR, Garcia, N, John, OP, Keltner, D.Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc Natl Acad Sci U S A 2009; 106: 21437–21441.CrossRefGoogle ScholarPubMed
70.Thompson, RJ, Parker, KJ, Hallmayer, JF, Waugh, CE, Gotlib, IH.Oxytocin receptor gene polymorphism (rs225 4298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls. Psychoneuroendocrinology 2011; 36: 144–147.CrossRefGoogle Scholar
71.Insel, TR.A neurobiological basis of social attachment. Am J Psychiatry 1997; 154: 726–735.Google ScholarPubMed
72.Bale, TL, Davis, AM, Auger, AP, Dorsa, DM, McCarthy, MM.CNS region-specific oxytocin receptor expression: importance in regulation of anxiety and sex behavior. J Neurosci 2001; 21: 2546–2552.CrossRefGoogle ScholarPubMed
73.Meddle, SL, Bishop, VR, Gkoumassi, E, Van Leeuwen, FW, Douglas, AJ.Dynamic changes in oxytocin receptor expression and activation at parturition in the rat brain. Endocrinology 2007; 148: 5095–5104.CrossRefGoogle ScholarPubMed
74.Champagne, F, Diorio, J, Sharma, S, Meaney, MJ.Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors. Proc Natl Acad Sci U S A 2001; 98: 12736–12741.CrossRefGoogle ScholarPubMed
75.Champagne, FA, Chretien, P, Stevenson, CW, Zhang, TY, Gratton, A, Meaney, MJ.Variations in nucleus accumbens dopamine associated with individual differences in maternal behavior in the rat. J Neurosci 2004; 24: 4113–4123.CrossRefGoogle ScholarPubMed
76.Norman, GJ, Karelina, K, Morris, JS, Zhang, N, Cochran, M, Courtney DeVries, A.Social interaction prevents the development of depressive-like behavior post nerve injury in mice: a potential role for oxytocin. Psychosom Med 2010; 72: 519–526.Google Scholar
77.Timmer, M, Cordero, MI, Sevelinges, Y, Sandi, C.Evidence for a role of oxytocin receptors in the long-term establishment of dominance hierarchies. Neuropsychopharmacology 2011; 36: 2349–2356.CrossRefGoogle ScholarPubMed
78.Lieberman, JA, Sheitman, BB, Kinon, BJ.Neurochemical sensitization in the pathophysiology of schizophrenia: deficits and dysfunction in neuronal regulation and plasticity. Neuropsychopharmacology 1997; 17: 205–229.CrossRefGoogle ScholarPubMed
79.Pruessner, JC, Champagne, F, Meaney, MJ, Dagher, A.Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using raclopride. J Neurosci 2004; 24: 2825–2831.CrossRefGoogle Scholar
80.Selten, JP, Cantor-Graae, E.Social defeat: risk factor for schizophrenia? Br J Psychiatry 2005; 187: 101–102.Google Scholar
81.Born, J, Lange, T, Kern, W, McGregor, GP, Bickel, U, Fehm, HL.Sniffing neuropeptides: a transnasal approach to the human brain. Nat Neurosci 2002; 5: 514–516.CrossRefGoogle ScholarPubMed
82.Illum, L.Is nose-to-brain transport of drugs in man a reality? J Pharm Pharmacol 2004; 56: 3–17.Google Scholar
83.Rossoni, E, Feng, J, Tirozzi, B, Brown, D, Leng, G, Moos, F.Emergent synchronous bursting of oxytocin neuronal network. PLoS Comput Biol 2008; 4: e1000123.CrossRefGoogle ScholarPubMed
84.Mens, WB, Witter, A, Van Wimersma Greidanus, TB.Penetration of neurohypophyseal hormones from plasma into cerebrospinal fluid (CSF): half-times of disappearance of these neuropeptides from CSF. Brain Res 1983; 262: 143–149.Google Scholar
85.Robinson, IC, Coombes, JE.Neurohypophysial peptides in cerebrospinal fluid: an update. Ann N Y Acad Sci 1993; 689: 269–284.Google Scholar
86.Robinson, IC, Jones, PM.Oxytocin and neurophysin in plasma and CSF during suckling in the guinea-pig. Neuroendocrinology 1982; 34: 59–63.Google Scholar
87.Carter, CS.Developmental consequences of oxytocin. Physiol Behav 2003; 79: 383–397.Google Scholar
88.Choleris, E, Devidze, N, Kavaliers, M, Pfaff, DW.Steroidal/neuropeptide interactions in hypothalamus and amygdala related to social anxiety. Prog Brain Res 2008; 170: 291–303.CrossRefGoogle ScholarPubMed
89.Patisaul, HB, Scordalakes, EM, Young, LJ, Rissman, EF.Oxytocin, but not oxytocin receptor, is regulated by oestrogen receptor beta in the female mouse hypothalamus. J Neuroendocrinol 2003; 15: 787–793.Google Scholar
90.Emiliano, AB, Cruz, T, Pannoni, V, Fudge, JL.The interface of oxytocin-labeled cells and serotonin transporter-containing fibers in the primate hypothalamus: a substrate for SSRIs therapeutic effects? Neuropsychopharmacology 2007; 32: 977–988.CrossRefGoogle ScholarPubMed
91.Baskerville, TA, Douglas, AJ.Dopamine and oxytocin interactions underlying behaviors: potential contributions to behavioral disorders. CNS Neurosci Ther 2010; 16: e92–e123.Google Scholar
92.Shahrokh, DK, Zhang, TY, Diorio, J, Gratton, A, Meaney, MJ.Oxytocin-dopamine interactions mediate variations in maternal behavior in the rat. Endocrinology 2010; 151: 2276–2286.CrossRefGoogle ScholarPubMed
93.Succu, S, Sanna, F, Melis, T, Boi, A, Argiolas, A, Melis, MR.Stimulation of dopamine receptors in the paraventricular nucleus of the hypothalamus of male rats induces penile erection and increases extra-cellular dopamine in the nucleus accumbens: involvement of central oxytocin. Neuropharmacology 2007; 52: 1034–1043.CrossRefGoogle ScholarPubMed
94.Hrabovszky, E, Liposits, Z.Novel aspects of glutamatergic signalling in the neuroendocrine system. J Neuroendocrinol 2008; 20: 743–751.Google Scholar
95.Ninan, I.Oxytocin suppresses basal glutamatergic transmission but facilitates activity-dependent synaptic potentiation in the medial prefrontal cortex. J Neurochem 2011; 119: 324–331.CrossRefGoogle ScholarPubMed
96.Sarnyai, Z, Szabo, G, Kovacs, GL, Telegdy, G.Oxytocin attenuates the cocaine-induced exploratory hyperactivity in mice. Neuroreport 1990; 1: 200–202.Google Scholar
97.Drago, F, Caldwell, JD, Pedersen, CA, Continella, G, Scapagnini, U, Prange, AJ Jr.Dopamine neurotransmission in the nucleus accumbens may be involved in oxytocin-enhanced grooming behavior of the rat. Pharmacol Biochem Behav 1986; 24: 1185–1188.Google Scholar
98.Drago, F, Contarino, A, Busa, L.The expression of neuropeptide-induced excessive grooming behavior in dopamine D1 and D2 receptor-deficient mice. Eur J Pharmacol 1999; 365: 125–131.CrossRefGoogle ScholarPubMed
99.Liu, Y, Wang, ZX.Nucleus accumbens oxytocin and dopamine interact to regulate pair bond formation in female prairie voles. Neuroscience 2003; 121: 537–544.Google Scholar
100.Kovacs, G, Telegdy, G.Effects of oxytocin, des-glycinamide-oxytocin and anti-oxytocin serum on the alpha-MPT-induced disappearance of catecholamines in the rat brain. Brain Res 1983; 268: 307–314.CrossRefGoogle ScholarPubMed
101.Qi, J, Yang, JY, Song, M, Li, Y, Wang, F, Wu, CF.Inhibition by oxytocin of methamphetamine-induced hyperactivity related to dopamine turnover in the mesolimbic region in mice. Naunyn Schmiedebergs Arch Pharmacol 2008; 376: 441–448.CrossRefGoogle ScholarPubMed
102.Uvnas-Moberg, K, Alster, P, Svensson, TH.Amperozide and clozapine but not haloperidol or raclopride increase the secretion of oxytocin in rats. Psychopharmacology (Berl) 1992; 109: 473–476.CrossRefGoogle ScholarPubMed
103.Kiss, A, Bundzikova, J, Pirnik, Z, Mikkelsen, JD.Different antipsychotics elicit different effects on magnocellular oxytocinergic and vasopressinergic neurons as revealed by Fos immunohistochemistry. J Neurosci Res 2010; 88: 677–685.Google Scholar
104.Souza, RP, Ismail, P, Meltzer, HY, Kennedy, JL.Variants in the oxytocin gene and risk for schizophrenia. Schizophr Res 2010; 121: 279–280.Google Scholar
105.Feifel, D, Reza, T.Oxytocin modulates psychotomimetic-induced deficits in sensorimotor gating. Psychopharmacology 1999; 141: 93–98.CrossRefGoogle ScholarPubMed
106.Caldwell, HK, Stephens, SL, Young, WS III.Oxytocin as a natural antipsychotic: a study using oxytocin knockout mice. Mol Psychiatry 2009; 14: 190–196.CrossRefGoogle ScholarPubMed
107.Lee, PR, Brady, DL, Shapiro, RA, Dorsa, DM, Koenig, JI.Social interaction deficits caused by chronic phencyclidine administration are reversed by oxytocin. Neuropsychopharmacology 2005; 30: 1883–1894.Google Scholar
108.Sams-Dodd, F.Phencyclidine in the social interaction test: an animal model of schizophrenia with face and predictive validity. Rev Neurosci 1999; 10: 59–90.CrossRefGoogle ScholarPubMed
109.Allen, RM, Young, SJ.Phencyclidine-induced psychosis. Am J Psychiatry 1978; 135: 1081–1084.Google ScholarPubMed
110.Lee, PR, Brady, DL, Shapiro, RA, Dorsa, DM, Koenig, JI.Prenatal stress generates deficits in rat social behavior: reversal by oxytocin. Brain Res 2007; 1156: 152–167.CrossRefGoogle ScholarPubMed
111.Brown, AS.The environment and susceptibility to schizophrenia. Prog Neurobiol 2011; 93: 23–58.Google Scholar
112.Van Os, J, Kenis, G, Rutten, BP.The environment and schizophrenia. Nature 2010; 468: 203–212.Google Scholar
113.Qi, J, Yang, JY, Wang, F, Zhao, YN, Song, M, Wu, CF.Effects of oxytocin on methamphetamine-induced conditioned place preference and the possible role of glutamatergic neurotransmission in the medial prefrontal cortex of mice in reinstatement. Neuropharmacology 2009; 56: 856–865.CrossRefGoogle ScholarPubMed
114.Meyer-Lindenberg, A, Miletich, RS, Kohn, PD et al. Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia. Nat Neurosci 2002; 5: 267–271.CrossRefGoogle ScholarPubMed
115.Weinberger, DR, Lipska, BK.Cortical maldevelopment, anti-psychotic drugs, and schizophrenia: a search for common ground. Schizophr Res 1995; 16: 87–110.Google Scholar
116.Feifel, D, Shilling, PD, Belcher, A.The effects of oxytocin and its analog, carbetocin, on genetic deficits in sensorimotor gating. Eur Neuropsychopharmacol 2011 (in press).Google ScholarPubMed
117.Feifel, D, Shilling, PD, Melendez, G.Clozapine and PD149163 elevate prepulse inhibition in Brown Norway rats. Behav Neurosci 2011; 125: 268–272.CrossRefGoogle ScholarPubMed
118.Carlsson, A.Does dopamine play a role in schizophrenia? Psychol Med 1977; 7: 583–597.CrossRefGoogle ScholarPubMed
119.Carlsson, A, Carlsson, ML.A dopaminergic deficit hypothesis of schizophrenia: the path to discovery. Dialog Clin Neurosci 2006; 8: 137–142.CrossRefGoogle ScholarPubMed
120.Sarter, M, Nelson, CL, Bruno, JP.Cortical cholinergic transmission and cortical information processing in schizophrenia. Schizophr Bull 2005; 31: 117–138.Google Scholar
121.Qiao, H, Noda, Y, Kamei, H et al. Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment. Neuroreport 2001; 12: 11–15.Google Scholar
122.Azorin, JM, Spiegel, R, Remington, G et al. A double-blind comparative study of clozapine and risperidone in the management of severe chronic schizophrenia. Am J Psychiatry 2001; 158: 1305–1313.CrossRefGoogle ScholarPubMed
123.Davis, JM, Chen, N, Glick, ID.A meta-analysis of the efficacy of second-generation antipsychotics. Archiv Gen Psychiatry 2003; 60: 553–564.Google Scholar
124.Lewis, SW, Barnes, TR, Davies, L et al. Randomized controlled trial of effect of prescription of clozapine versus other second-generation antipsychotic drugs in resistant schizophrenia. Schizophr Bull 2006; 32: 715–723.Google Scholar
125.Souza, RP, de Luca, V, Meltzer, HY, Lieberman, JA, Kennedy, JL.Schizophrenia severity and clozapine treatment outcome association with oxytocinergic genes. Int J Neuropsychopharmacol 2010; 13: 793–798.Google Scholar
126.Koenig, JI, Elmer, GI, Shepard, PD et al. Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia. Behav Brain Res 2005; 156: 251–261.CrossRefGoogle ScholarPubMed
127.Huber, D, Veinante, P, Stoop, R.Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 2005; 308: 245–248.Google Scholar
128.Viviani, D, Charlet, A, Van Den Burg, E et al. Oxytocin selectively gates fear responses through distinct outputs from the central amygdala. Science 2011; 333: 104–107.CrossRefGoogle ScholarPubMed
129.Adolphs, R.How do we know the minds of others? Domain-specificity, simulation, and enactive social cognition. Brain Res 2006; 1079: 25–35.CrossRefGoogle ScholarPubMed
130.Braff, DL, Geyer, MA, Swerdlow, NR.Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology (Berl) 2001; 156: 234–258.Google Scholar
131.Geyer, MA, Krebs-Thomson, K, Braff, DL, Swerdlow, NR.Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology (Berl) 2001; 156: 117–154.CrossRefGoogle ScholarPubMed
132.Koch, M, Schnitzler, HU.The acoustic startle response in rats –circuits mediating evocation, inhibition and potentiation. Behav Brain Res 1997; 89: 35–49.CrossRefGoogle ScholarPubMed
133.Swerdlow, NR, Geyer, MA, Braff, DL.Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology (Berl) 2001; 156: 194–215.CrossRefGoogle ScholarPubMed
134.Geyer, MA, Ellenbroek, B.Animal behavior models of the mechanisms underlying antipsychotic atypicality. Prog Neuropsychopharmacol Biol Psychiatry 2003; 27: 1071–1079.Google Scholar
135.Palmer, AA, Dulawa, SC, Mottiwala, AA, Conti, LH, Geyer, MA, Printz, MP.Prepulse startle deficit in the Brown Norway rat: a potential genetic model. Behav Neurosci 2000; 114: 374–388.Google Scholar
136.Ferguson, JN, Aldag, JM, Insel, TR, Young, LJ.Oxytocin in the medial amygdala is essential for social recognition in the mouse. J Neurosci 2001; 21: 8278–8285.CrossRefGoogle ScholarPubMed
137.Mantella, RC, Vollmer, RR, Li, X, Amico, JA.Female oxytocin-deficient mice display enhanced anxiety-related behavior. Endocrinology 2003; 144: 2291–2296.CrossRefGoogle ScholarPubMed
138.Teltsh, O, Kanyas-Sarner, K, Rigbi, A, Greenbaum, L, Lerer, B, Kohn, Y.Oxytocin and vasopressin genes are significantly associated with schizophrenia in a large Arab-Israeli pedigree. Int J Neuropsychopharmacol 2011. [E-pub ahead of print; DOI: 10.1017/S1461145711001374]Google Scholar
139.Feifel, D, Shilling, PD.Promise and pitfalls of animal models of schizophrenia. Curr Psychiatry Rep 2010; 12: 327–334.CrossRefGoogle ScholarPubMed
140.Linkowski, P, Geenen, V, Kerkhofs, M, Mendlewicz, J, Legros, JJ.Cerebrospinal fluid neurophysins in affective illness and in schizophrenia. Eur Arch Psychiatry Neurol Sci 1984; 234: 162–165.Google Scholar
141.Legros, JJ, Gazzotti, C, Carvelli, T et al. Apomorphine stimulation of vasopressin- and oxytocin-neurophysins. Evidence for increased oxytocinergic and decreased vasopressinergic function in schi-zophrenics. Psychoneuroendocrinology 1992; 17: 611–617.CrossRefGoogle Scholar
142.Beckmann, H, Lang, RE, Gattaz, WF.Vasopressin – oxytocin in cerebrospinal fluid of schizophrenic patients and normal controls. Psychoneuroendocrinology 1985; 10: 187–191.Google Scholar
143.Nussey, SS, Hawthorn, J, Page, SR, Ang, VT, Jenkins, JS.Responses of plasma oxytocin and arginine vasopressin to nausea induced by apomorphine and ipecacuanha. Clin Endocrinol 1988; 28: 297–304.CrossRefGoogle ScholarPubMed
144.Baskerville, TA, Allard, J, Wayman, C, Douglas, AJ.Dopamine-oxytocin interactions in penile erection. Eur J Neurosci 2009; 30: 2151–2164.Google Scholar
145.Melis, MR, Argiolas, A.Central control of penile erection: a re-visitation of the role of oxytocin and its interaction with dopamine and glutamic acid in male rats. Neurosci Biobehav Rev 2011; 35: 939–955.CrossRefGoogle ScholarPubMed
146.Mai, JK, Berger, K, Sofroniew, MV.Morphometric evaluation of neurophysin-immunoreactivity in the human brain: pronounced inter-individual variability and evidence for altered staining patterns in schizophrenia. Journal fur Hirnforschung 1993; 34: 133–154.Google Scholar
147.Glovinsky, D, Kalogeras, KT, Kirch, DG, Suddath, R, Wyatt, RJ.Cerebrospinal fluid oxytocin concentration in schizophrenic patients does not differ from control subjects and is not changed by neuroleptic medication. Schizophr Res 1994; 11: 273–276.Google Scholar
148.Goldman, MB, Gomes, AM, Carter, CS, Lee, R.Divergent effects of two different doses of intranasal oxytocin on facial affect discrimination in schizophrenic patients with and without polydipsia. Psychopharmacology 2011; 216: 101–110.CrossRefGoogle ScholarPubMed
149.Goldman, MB, Wood, G, Gavin, M et al. Diminished glucocorticoid negative feedback in polydipsic hyponatremic schizophrenic patients. J Clin Endocrinol Metab 2007; 92: 698–704.CrossRefGoogle ScholarPubMed
150.Goldman, MB, Wang, L, Wachi, C et al. Structural pathology underlying neuroendocrine dysfunction in schizo phrenia. Behav Brain Res 2011; 218: 106–113.Google Scholar
151.Keri, S, Kiss, I, Kelemen, O.Sharing secrets: oxytocin and trust in schizophrenia. Soc Neurosci 2009; 4: 287–293.CrossRefGoogle ScholarPubMed
152.Bartz, JA, Zaki, J, Bolger, N, Ochsner, KN.Social effects of oxytocin in humans: context and person matter. Trends Cogn Sci 2011; 15: 301–309.Google ScholarPubMed
153.Walker, E, Mittal, V, Tessner, K.Stress and the hypothalamic pituitary adrenal axis in the developmental course of schizophrenia. Annu Rev Clin Psychol 2008; 4: 189–216.CrossRefGoogle ScholarPubMed
154.Averbeck, BB, Bobin, T, Evans, S, Shergill, SS.Emotion recognition and oxytocin in patients with schizophrenia. Psychol Med 2011. [E-pub ahead of print; DOI: 10.1017/S0033291711001413]Google Scholar
155.Mendrek, A, Stip, E.Sexual dimorphism in schizophrenia: is there a need for gender-based protocols? Expert RevNeurother 2011; 11: 951–959.CrossRefGoogle Scholar
156.Figueira, ML, Ouakinin, S.Gender-related endocrinological dysfunction and mental disorders. Curr Opin Psychiatry 2010; 23: 369–372.Google Scholar
157.Murakami, G et al. Relationships among estrogen receptor, oxytocin and vasopressin gene expression and social interaction in male mice. Eur J Neurosci 2011; 34: 469–477.Google Scholar
158.Popeski, N et al. Prolactin and oxytocin interaction in the paraventricular and supraoptic nuclei: effects on oxytocin mRNA and nitric oxide synthase. J Neuroendocrinol 2003; 15: 687–696.CrossRefGoogle ScholarPubMed
159.Gordon, I et al. Oxytocin and the development of parenting in humans. Biol Psychiatry 2010; 68: 377–382.Google Scholar
160.Holt-Lunstad, J, Birmingham, W, Light, KC.The influence of depressive symptomatology and perceived stress on plasma and salivary oxytocin before, during and after a support enhancement intervention. Psychoneuroendocrinology 2011; 36: 1249–1256.CrossRefGoogle ScholarPubMed
161.Bernstein, HG, Stanarius, A, Baumann, B et al. Nitric oxide synthase-containing neurons in the human hypothalamus: reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Neuroscience 1998; 83: 867–875.CrossRefGoogle ScholarPubMed
162.Goldman, MB, Torres, IJ, Keedy, S, Marlow-O'Connor, M, Beenken, B, Pilla, R.Reduced anterior hippocampal formation volume in hyponatremic schizophrenic patients. Hippocampus 2007; 17: 554–562.CrossRefGoogle ScholarPubMed
163.Pedersen, C, Rau, S, Salimi, K, Gibson, C, Leserman, J, Penn, D. Oxytocin treatment improves social cognition and reduces psychotic symptoms in schizophrenia (poster). Paper presented at the American College of Neuropsychopharmacology. 2010.Google Scholar
164.Kosfeld, M, Heinrichs, M, Zak, PJ, Fischbacher, U, Fehr, E.Oxytocin increases trust in humans. Nature 2005; 435: 673–676.CrossRefGoogle ScholarPubMed
165.Zak, PJ, Kurzban, R, Matzner, WT.Oxytocin is associated with human trustworthiness. Horm Behav 2005; 48: 522–527.CrossRefGoogle ScholarPubMed
166.Engell, AD, Haxby, JV, Todorov, A.Implicit trustworthiness decisions: automatic coding of face properties in the human amygdala. J Cogn Neurosci 2007; 19: 1508–1519.CrossRefGoogle ScholarPubMed
167.Koscik, TR, Tranel, D.The human amygdala is necessary for developing and expressing normal interpersonal trust. Neuropsychologia 2011; 49: 602–611.CrossRefGoogle ScholarPubMed
168.Wizemann, TM, Pardue, ML., eds. Exploring biological contributions to human health: does sex matter? Washington, DC: National Academy Press, 2001.Google Scholar
169.Liedman, R, Hansson, SR, Howe, D et al. Reproductive hormones in plasma over the menstrual cycle in primary dysmenorrhea compared with healthy subjects. Gynecol Endocrinol 2008; 24: 508–513.Google Scholar
170.Salonia, A, Nappi, RE, Pontillo, M et al. Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy women. Horm Behav 2005; 47: 164–169.Google Scholar
171.Shukovski, L, Healy, DL, Findlay, JK.Circulating immunoreactive oxytocin during the human menstrual cycle comes from the pituitary and is estradiol dependent. J Clin Endocrinol Metab 1989; 68: 455–460.Google Scholar
172.Stock, S, Bremme, K, Uvnas-Moberg, K.Plasma levels of oxytocin during the menstrual cycle, pregnancy and following treatment with HMG. Hum Reprod 1991; 6: 1056–1062.Google Scholar
173.Silber, M, Almkvist, O, Larsson, B, Stock, S, Uvnas-Moberg, K.The effect of oral contraceptive pills on levels of oxytocin in plasma and on cognitive functions. Contraception 1987; 36: 641–650.CrossRefGoogle ScholarPubMed
174.Stock, S, Karlsson, R, von Schoultz, B.Serum profiles of oxytocin during oral contraceptive treatment. Gynecol Endocrinol 1994; 8: 121–126.Google Scholar
175.Bergemann, N, Parzer, P, Runnebaum, B, Resch, F, Mundt, C.Estrogen, menstrual cycle phases, and psychopathology in women suffering from schizophrenia. Psychol Med 2007; 37: 1427–1436.CrossRefGoogle ScholarPubMed
176.Van Anders, SM, Goldey, KL, Kuo, PX.The steroid/ peptide theory of social bonds: integrating testosterone and peptide responses for classifying social behavioral contexts. Psychoneuroendocrinology 2011; 36: 1265–1275.Google Scholar
177.Tandon, R, Keshavan, MS, Nasrallah, HA.Schizophrenia, “just the facts” what we know in 2008. 2. Epidemiology and etiology. Schizophr Res 2008; 102: 1–18.CrossRefGoogle Scholar
178.Grewen, KM, Girdler, SS, Amico, J, Light, KC.Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact. Psychosom Med 2005; 67: 531–538.CrossRefGoogle ScholarPubMed
179.Taylor, SE, Klein, LC, Lewis, BP, Gruenewald, TL, Gurung, RA, Updegraff, JA.Biobehavioral responses to stress in females: tend-and-befriend, not fight-or-flight. Psychol Rev 2000; 107: 411–429.CrossRefGoogle Scholar
180.Bakharev, VD, Tikhomirov, SM, Lozhkina, TK.Psychotropic properties of oxytocin. Neurosci Behav Physiol 1986; 16: 160–164.CrossRefGoogle ScholarPubMed
181.Calder, A et al. Facial emotion recognition after bilateral amygdala damage: differentially severe impairment of fear. Cogn Neuropsychol 1996; 13: 699–745.Google Scholar
182.Bruins, J, Hijman, R, Van Ree, JM.Effect of a single dose of des-glycinamide-[Arg8]vasopressin or oxytocin on cognitive processes in young healthy subjects. Peptides 1992; 13: 461–468.CrossRefGoogle ScholarPubMed
183.Fehm-Wolfsdorf, G, Born, J, Voigt, KH, Fehm, HL.Human memory and neurohypophyseal hormones: opposite effects of vasopressin and oxytocin. Psychoneuroendocrinology 1984; 9: 285–292.Google Scholar
184.Feifel, D, Cobb, P, MacDonald, K, Nguyen, A, Minassian, A, Perry, W. Daily intranasal oxytocin improves verbal memory in schizophrenia patients (poster). Paper presented at the American College of Neuropsychopharmacology. 2010.Google Scholar
185.Macdonald, K, Macdonald, TM.The peptide that binds: a systematic review of oxytocin and its prosocial effects in humans. Harv Rev Psychiatry 2010; 18: 1–21.CrossRefGoogle ScholarPubMed
186.Tremeau, F.A review of emotion deficits in schizophrenia. Dialogues Clin Neurosci 2006; 8: 59–70.CrossRefGoogle ScholarPubMed
187.Fett, AK, Viechtbauer, W, Dominguez, MD, Penn, DL, Van Os, J, Krabbendam, L.The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci Biobehav Rev 2011; 35: 573–588.Google Scholar
188.Penn, DL., Keefe, RS, Davis, SM, Meyer, PS, Perkins, DO, Losardo, D, et al. The effects of antipsychotic medications on emotion perception in patients with chronic schizophrenia in the CATIE trial. Schizophrenia research 2009; 115: 17–23.CrossRefGoogle ScholarPubMed
189.Ursu, S, Kring, AM, Gard, MG et al. Prefrontal cortical deficits and impaired cognition-emotion interactions in schizophrenia. Am J Psychiatry 2011; 168: 276–285.Google Scholar
190.Macdonald, E, Dadds, MR, Brennan, JL, Williams, K, Levy, F, Cauchi, AJ.A review of safety, side-effects and subjective reactions to intranasal oxytocin in human research. Psychoneuroendocrinology 2011; 36: 1114–1126.Google Scholar
191.Ohlsson, B, Truedsson, M, Bengtsson, M et al. Effects of long-term treatment with oxytocin in chronic constipation; a double blind, placebo-controlled pilot trial. Neurogastroenterol Motil 2005; 17: 697–704.Google Scholar
192.Rummel-Kluge, C, Komossa, K, Schwarz, S et al. Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis. Schizophr Res 2010; 123: 225–233.CrossRefGoogle ScholarPubMed
193.Rasmussen, MS, Simonsen, JA, Sandgaard, NC, Hoilund-Carlsen, PF, Bie, P.Effects of oxytocin in normal man during low and high sodium diets. Acta Physiol Scand 2004; 181: 247–257.Google Scholar
194.Kubzansky, LD, Mendes, WB, Appleton, A, Block, J, Adler, GK.Protocol for an experimental investigation of the roles of oxytocin and social support in neuroendocrine, cardiovascular, and subjective responses to stress across age and gender. BMC Public Health 2009; 9: 481.Google Scholar
195.Bryant, RA, Hung, L, Guastella, AJ, Mitchell, PB.Oxytocin as a moderator of hypnotizability. Psychoneuroendocrinology 2011 (in press).Google Scholar
196.Roberts, DL, Penn, DL.Social cognition and interaction training (SCIT) for outpatients with schizophrenia: a preliminary study. Psychiatry Res 2009; 166: 141–147.CrossRefGoogle ScholarPubMed
197.Ceanga, M, Spataru, A, Zagrean, AM.Oxytocin is neuroprotective against oxygen-glucose deprivation and reoxygenation in immature hippocampal cultures. Neurosci Lett 2010; 477: 15–18.CrossRefGoogle ScholarPubMed
198.Cohen, H, Kaplan, Z, Kozlovsky, N, Gidron, Y, Matar, MA, Zohar, J.Hippocampal microinfusion of oxytocin attenuates the behavioural response to stress by means of dynamic interplay with the glucocorticoid-catecholamine responses. J Neuroendocrinol 2010; 22: 889–904.CrossRefGoogle ScholarPubMed
199.Leuner, B, Caponiti, JM, Gould, E.Oxytocin stimulates adult neurogenesis even under conditions of stress and elevated glucocorticoids. Hippocampus 2011 (in press).Google Scholar
200.Tomizawa, K, Iga, N, Lu, YF, et al. Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade. Nat Neurosci 2003; 6: 384–390.Google Scholar
201.Windle, RJ, Kershaw, YM, Shanks, N, Wood, SA, Lightman, SL, Ingram, CD.Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity. J Neurosci 2004; 24: 2974–2982.CrossRefGoogle ScholarPubMed