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Serum total oxidant and antioxidant status in earthquake survivors with post-traumatic stress disorder

Published online by Cambridge University Press:  19 January 2015

Pinar Guzel Ozdemir ,
İbrahim Kaplan ,
Cem Uysal ,
Mahmut Bulut ,
Abdullah Atli ,
Yasin Bez ,
Mehmet Cemal Kaya  and
Osman Ozdemir
Pinar Guzel Ozdemir*
Affiliation:
Medicine Faculty, Department of Psychiatry, Yuzuncu Yil University, Van, Turkey
İbrahim Kaplan
Affiliation:
Department of Biochemistry, Dicle University, Diyarbakir,Turkey
Cem Uysal
Affiliation:
Department of Forensic Medicine, Dicle University, Diyarbakir,Turkey
Mahmut Bulut
Affiliation:
Medicine Faculty, Department of Psychiatry, Dicle University, Diyarbakir, Turkey
Abdullah Atli
Affiliation:
Medicine Faculty, Department of Psychiatry, Dicle University, Diyarbakir, Turkey
Yasin Bez
Affiliation:
Medicine Faculty, Department of Psychiatry, Marmara University, İstanbul, Turkey
Mehmet Cemal Kaya
Affiliation:
Medicine Faculty, Department of Psychiatry, Dicle University, Diyarbakir, Turkey
Osman Ozdemir
Affiliation:
Medicine Faculty, Department of Psychiatry, Yuzuncu Yil University, Van, Turkey
*
Dr. Pinar Guzel Ozdemir, Medicine Faculty, Department of Psychiatry, Yuzuncu Yil University, Van 65200, Turkey. Tel: +905056179746; Fax: +904322167519; E-mail: pguzelozdemir@yahoo.com
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Abstract

Objective

Oxidative stress has been shown to play an important role in the pathogenesis of post-traumatic stress disorder (PTSD). Although there are some studies on oxidative stress and PTSD, there is no report available on the serum total oxidant and antioxidant status in earthquake survivors with PTSD. Therefore, this study aimed to investigate the serum total oxidant and antioxidant status in earthquake survivors with chronic PTSD.

Material and Methods

The study group included 45 earthquake survivors with PTSD and 40 earthquake survivors without PTSD. The oxidative status was determined using the total antioxidant status and total oxidant status (TOS) measurements and by calculating the oxidative stress index (OSI).

Results

There were no statistically significant differences in the total antioxidant status, TOS, or OSI when comparing individuals with and without PTSD (all, p>0.05). There were no correlations between Clinician-Administered PTSD Scale scores and oxidant and antioxidant stress markers (all, p>0.05).

Conclusions

Our results suggest that the total oxidant and antioxidant status may not affect earthquake survivors with PTSD. This is the first study to evaluate the oxidative status in earthquake survivors with PTSD. Further studies are necessary to confirm these findings.

Keywords

earthquake survivorsoxidative stress indexpost-traumatic stress disordertotal antioxidant statustotal oxidant status
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 27 , Issue 3 , June 2015 , pp. 153 - 158
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Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

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References

1.Basoglu, M, Kilic, C, Salcioglu, E, Livanou, M. Prevalence of posttraumatic stress disorder and comorbid depression in earthquake survivors in Turkey: an epidemiological study. J Trauma Stress 2004;17:133–141.CrossRefGoogle ScholarPubMed
2.AFAD. Disaster report|Van earthquake 2012. https://www.afad.gov.tr.Google Scholar
3.Bunting, BP, Ferry, FR, Murphy, SD, O’neill, SM, Bolton, D. Trauma associated with civil conflict and posttraumatic stress disorder: evidence from the Northern Ireland study of health and stress. J Trauma Stress 2013;26:134–141.CrossRefGoogle ScholarPubMed
4.Basoglu, M, Salcioglu, E, Livanou, M. Traumatic stress responses in earthquake survivors in Turkey. J Trauma Stress 2002;15:269–276.CrossRefGoogle ScholarPubMed
5.NG, F, Berk, M, Dean, O, Bush, AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychoph 2008;11:851–876.CrossRefGoogle ScholarPubMed
6.Huang, CJ, Webb, HE, Evans, RKet al. Psychological stress during exercise. Immunoendocrine and oxidative stress. Exp Biol Med 2010;235:1498–1504.CrossRefGoogle Scholar
7.Herken, H, UZ, E, Ozyurt, H, Sogut, S, Virit, O, Akyol, O. Evidence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation ape increased in different forms of schizophrenia. Mol Psychiatry 2001;6:66–73.CrossRefGoogle ScholarPubMed
8.Yao, JK, Reddy, R, Mcelhinny, LG, Van Kammen, DP. Reduced status of plasma total antioxidant capacity in schizophrenia. Schizophr Res 1998;32:1–8.CrossRefGoogle ScholarPubMed
9.Yanik, M, Vural, H, Kocyigit, Aet al. Is the arginine-nitric oxide pathway involved in the pathogenesis of schizophrenia? Neuropsychobiology 2003;47:61–65.CrossRefGoogle ScholarPubMed
10.Frey, BN, Andreazza, AC, Kunz, Met al. Increased oxidative stress and DNA damage in bipolar disorder: a twin-case report. Prog NeuroPsychoph 2007;31:283–285.CrossRefGoogle ScholarPubMed
11.Selek, S, Savas, HA, Gergerlioglu, HS, Bulbul, F, UZ, E, Yumru, M. The course of nitric oxide and superoxide dismuTACe during treatment of bipolar depressive episode. J Affect Disord 2008;107:89–94.CrossRefGoogle ScholarPubMed
12.Hovatta, I, Juhila, J, Donner, J. Oxidative stress in anxiety and comorbid disorders. Neurosci Res 2010;68:261–275.CrossRefGoogle ScholarPubMed
13.Bouayed, J, Rammal, H, Soulimani, R. Oxidative stress and anxiety relationship and cellular pathways. Oxid Med Cell Longev 2009;2:63–67.CrossRefGoogle ScholarPubMed
14.Selek, S, Herken, H, Bulut, Met al. Oxidative imbalance in obsessive compulsive disorder patients: a total evaluation of oxidant-antioxidant status. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:487–491.CrossRefGoogle ScholarPubMed
15.Tezcan, E, Atmaca, M, Kuloglu, M, Ustundag, B. Free radicals in patients with post-traumatic stress disorder. Eur Arch Psychiatry Clin Neurosci 2003;253:89–91.CrossRefGoogle ScholarPubMed
16.Attari, A, Naderi Attari, GA, Rezayat, A. Lipid peroxidation and antioxidant capacity in posttraumatic stress disorder. J Isfahan Med Sch 2002;20:4–6.Google Scholar
17.Terawaki, H, Terada, T, Ogura, M, Era, S, Hosoya, T. The elevation of oxidative stress after the great East Japan earthquake. Clin Exp Nephrol 2012;16:816–817.CrossRefGoogle ScholarPubMed
18.Song, Y, Zhou, D, Wang, X. Increased serum cortisol and growth hormone levels in earthquake survivors with PTSD or subclinical PTSD. Psychoneuroendocrinology 2008;33:1155–1159.CrossRefGoogle ScholarPubMed
19.Erel, O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 2004;37:277–285.CrossRefGoogle ScholarPubMed
20.Blake, DD, Weathers, FW, Nagy, LMet al. The development of a Clinician-Administered PTSD Scale. J Trauma Stress 1995;8:75–90.Google ScholarPubMed
21.Aker, AT, Özeren, M, Basoglu, M, Kaptanoglu, C, Erol, A, Buran, B. Clinician administered post traumatic stress disorder scale (CAPS) reliability and validity study. Turk J Psychiatry 1999;10:286–293.Google Scholar
22.Guy, WE. ECDEU assessment manual for psychopharmacology. Rockville: US Department of Health, Education, and Welfare, 1976.Google Scholar
23.Kadouri, A, Corruble, E, Falissard, B. The improved clinical global impression scale (iCGI): development and validation in depression. BMC Psychiatry 2007;6:7.CrossRefGoogle Scholar
24.Erel, O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005;38:1103–1111.CrossRefGoogle ScholarPubMed
25.Erel, O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem 2004;37:112–119.CrossRefGoogle ScholarPubMed
26.Aslan, M, Nazligul, Y, Horoz, M, et al. Serum prolidase activity and oxidative status in Helicobacter pylori infection. Clin Biochem 2007;40:37–40.CrossRefGoogle ScholarPubMed
27.Gulec, M, Ozkol, H, Selvi, Yet al. Oxidative stress in patients with primary insomnia. Prog Neuropsychopharmacol Biol Psychiatry 2012;37(2):247–251.CrossRefGoogle ScholarPubMed
28.Richards, RS, Nwose, EU, Bwititi, P. Biochemical basis of circadian rhythms and diseases: with emphasis on post-traumatic stress disorder. Med Hypotheses 2011;77:605–609.CrossRefGoogle ScholarPubMed
29.Yu, BP. Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994;74:139–162.CrossRefGoogle ScholarPubMed
30.Bilici, M, EFE, H, Koroglu, MA, Uydu, HA, Bekaroglu, M, Deger, O. Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. J Affect Disord 2001;64:43–51.CrossRefGoogle ScholarPubMed
31.Saito, K, Aoki, H, Fujiwara, N, Goto, M, Tomiyama, C, Iwasa, Y. Association of urinary 8-OHdG with lifestyle and body composition in elderly natural disaster victims living in emergency temporary housing. Environ Health Prev 2013;18:72–77.CrossRefGoogle ScholarPubMed
32.Borovac Stefanovic, L, Kalinic, D, Mimica, Net al. Oxidative status and the severity of clinical symptoms in patients with post-traumatic stress disorder. Ann Clin Biochem 2014:4.Google ScholarPubMed
33.Ceprnja, M, Derek, L, Unic, Aet al. Oxidative stress markers in patients with post-traumatic stress disorder. Coll Antropol 2011;35:1155–1160.Google ScholarPubMed
34.Wayner, DDM, Burton, GW, Ingold, KU, Barclay, LRC, Locke, SJ. The relative contributions of vitamin-E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human-blood plasma. Biochim Biophys Acta 1987;22:408–419.CrossRefGoogle Scholar