Active drag reduction systems, such as hybrid laminar flow control (HLFC), have the potential for significant fuel savings; however, this is at the expense of an increase in aircraft weight and engine power off-take. A computer program – capable of accurately determining the trip fuel for a given mission profile – has been developed. The program was validated against manufacturer’s payload-range data, and then modified to emulate the installation of an active drag reduction system, by incorporating changes to the drag polars, specific fuel consumption (SFC) data and operating empty weight (OEW). Results of sensitivity studies are presented that enable the reduction in trip fuel to be determined for given changes in CD, SFC and OEW. The underlying assumption of linear independence of the three parameters is explored. The linearised method was observed to underestimate the fuel savings of the HLFC aircraft by approximately 0·6% compared to an analysis which took into account the coupling between the parameters. A mathematical relationship has been established to estimate the impact on cruise fuel burn arising from relative changes to the aircraft’s mass, lift-to-drag ratio and SFC.