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Published online by Cambridge University Press: 01 August 2014
The old concept of constitution, which has been dominating Medicine until this century, has to be revised in the light of the development of Medical Genetics and of Clinical Genetics, this new branch which is applied at the beside of the single diseased.
The study of the family of the patient from a genetic point of view is both possible and precious. The basic principles of the hereditary analysis are recalled, and the Author especially stresses how useful it can be to consider the temporary virtuality of the hereditary unity, which he suggests to call chronon. The study of the chronon of the genes contained in the genetic background of the family enables to visualize many a possibility in the future of the patient, such as the mean age of onset for a hereditary disease, or the steps of extinction in the course of ageing.
The therapy of a hereditary disease may be conceived in terms of a substitutive therapy.
Deuxième Rapport au Séminaire de Génétique Humaine Appliquée organisé par le C.I.O.M.S. à Copenhague du 25 au 29 août 1964 - Le premier Rapport a été publiée sur A. Ge. Me. Ge., XIII, 4, sous le titre: «La complexe contribution du génotype à la prédisposition morbide».