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A New Estimate of Genetic Load from Inbreeding Data

Published online by Cambridge University Press:  01 August 2014

Ademar Freire-Maia
Ademar Freire-Maia*
Affiliation:
Departamento de Genética, Faculdade de Ciências Médicas e Biológicas, Botucatú, São Paulo
*
Departamento de Genética, Faculdade de Ciências Médicas e Biológicas, Botucatú, Est. São Paulo, Brazil

Summary

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Inbreeding effect revealed as mortality and morbidity in general may be ascribed to deleterious mutations generally present at different loci of the ancestors common to each consanguineous mating. A new coefficient (E) is suggested to measure this effect. On the basis of this theory, a new method to estimate the load of mutations disclosed by inbreeding has been presented elsewhere, and is now extended. In this method, the load is estimated without introducing gene frequency notions. Genetic loads estimated through our method are in rather close agreement to those estimated through the classical theory of Morton, Crow and Muller (MCM).

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 19 , Issue 4 , October 1970 , pp. 507 - 514
Copyright
Copyright © The International Society for Twin Studies 1970

References

Freire-Maia, A. (1969). Human genetic studies in areas of high natural radiation. I. Methodology. Acta Genet. Med. Gemellol., 18: 175–212.CrossRefGoogle ScholarPubMed
Freire-Maia, A., Freire-Maia, N. (1965a). Estimativa do efeito genético dos casamentos consanguíneos. Cienc. Cult., 17: 539–547.Google Scholar
Freire-Maia, A., Freire-Maia, N. (1965b). Genetic load and undetected abortions. Amer. J. Hum. Genet., 17: 93–94.Google ScholarPubMed
Freire-Maia, N. (1964), On the methods available for estimating the load of mutations disclosed by inbreeding. Cold Spring Harb. Symp. Quant. Biol., 29: 31–40.CrossRefGoogle ScholarPubMed
Freire-Maia, N., Freire-Maia, A. (1964). Estimate of the genetic load disclosed by inbreeding. Genetics, 50: 527–529.CrossRefGoogle ScholarPubMed
Frota-Pessoa, O. (1966). Lethal equivalents acting before birth. Amer. J. Hum. Genet., 18: 57–61.Google ScholarPubMed
Morton, N. E. (1960). The mutational load due to detrimental genes in man. Amer. J. Hum. Genet., 12: 348–364.Google ScholarPubMed
Morton, N. E., Crow, J. F., Muller, H. J. (1956). An estimate of the mutational damage in man from data on consanguineous marriages. Proc. Nat. Acad. Sci. USA, 42: 855–863.CrossRefGoogle ScholarPubMed
Muller, H. J. (1950). Our load of mutations. Amer. J. Hum. Genet., 2: 111–176.Google ScholarPubMed
Slatis, H. M. (1960). An analysis of inbreeding in the European bison. Genetics, 45: 275–287.CrossRefGoogle ScholarPubMed
Wright, S. (1921). Systems of mating. I. The biometric relations between parent and offspring. Genetics, 6: 111–123.CrossRefGoogle ScholarPubMed
Wright, S. (1922). Coefficients of inbreeding and relationship. Amer. Nat., 56: 330–338.CrossRefGoogle Scholar