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Psychiatric Hospitalization in Twins

Published online by Cambridge University Press:  01 August 2014

M. Koskenvuo ,
H. Langinvainio ,
J. Kaprio ,
J. Lönnqvist  and
P. Tienari
M. Koskenvuo*
Affiliation:
Department of Public Health Science, University of Helsinki, Finland
H. Langinvainio
Affiliation:
Department of Public Health Science, University of Helsinki, Finland
J. Kaprio
Affiliation:
Department of Public Health Science, University of Helsinki, Finland
J. Lönnqvist
Affiliation:
Department of Psychiatry, University of Helsinki, Finland
P. Tienari
Affiliation:
Department of Psychiatry, University of Oulu, Finland
*
Department of Public Health Science, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki 29, Finland

Abstract

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Hospitalization rates of monozygotic (MZ) and dizygotic (DZ) twin pairs in Finland were compared for schizophrenia, neuroses, and alcoholism. Record-linkage of hospital records and death certificates for the years 1972-1979 was carried out for persons in the Finnish Twin Cohort (16,649 like-sexed twin pairs). The ratio of the number of observed vs that of expected concordant pairs and the ratio of concordance rates between MZ and DZ pairs were greater among males than females, and greater among young (40 years old or less) than among older pairs. The highest difference was found in schizophrenia and the lowest in neuroses. Pairwise concordance rates for schizophrenia (11.0% for MZ and 1.8% for DZ) seem to indicate great environmental influence (high proportion of discordant pairs) with apparent genetic liability (6.1-fold ratio in concordance between MZ and DZ pairs). In neurotic disorders, the difference of pairwise concordance rates between MZ and DZ pairs (6.8% vs 4.0%) was quite low, not strongly supporting a genetic hypothesis. Of the MZ pairs concordant for psychiatric hospitalization, 47% had lived together for their whole life time; of those discordant, 16% lived together. The corresponding figures for DZ pairs were 18% and 15%. The effect of intrapair relationships in disease-concordant pairs should be taken into account when evaluating the effect of genetic and environmental factors in psychiatric disorders.

Keywords

Twin concordancePsychiatric hospitalizationSchizophreniaNeurosisAlcoholism
Type
Genetics of Psychopathology
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 33 , Issue 2 , April 1984 , pp. 321 - 332
Copyright
Copyright © The International Society for Twin Studies 1984

References

REFERENCES

1.Baron, M, Gruen, R, Asnis, L (1982): Schizophrenia: A comparative study of patients with and without family history. Br J Psychiatry 140:516–517.CrossRefGoogle ScholarPubMed
2.Belmaker, R, Pollin, W, Wyatt, RJ, Cohen, S (1974): A follow-up of monozygotic twins discordant for schizophrenia. Arch Gen Psychiatry 30:219–222.CrossRefGoogle ScholarPubMed
3.Cederlöf, R, Friberg, L, Jonsson, E, Kail, L (1961): Studies on similarity diagnosis in twins with the aid of mailed questionnaires. Acta Genet 11:338–348.Google Scholar
4.Dalgard, OS, Kringlen, E (1976): A Norwegian twin study of criminality. Br J Criminol 16:213–232.Google Scholar
5.Eysenck, HJ (1976): Genetic factors in personality development. In Vandenberg, S (ed): Progress in Human Behavior Genetics. Baltimore: John Hopkins Press.Google Scholar
6.Fischer, M, Harvald, B, Hauge, M (1969): A Danish twin study of schizophrenia. Br J Psychiatry 115:981–990.Google Scholar
7.Fischer, M (1973): Genetic and environmental factors in schizophrenia. Acta Psychiatr Scand Suppl 238.Google Scholar
8.Gottesman, II, Shields, J (1972): Schizophrenia and genetics: twin study advantage point. New York: Academic Press.Google Scholar
9.Gottesman, II, Shields, J (1976): A critical review of recent adoption, twin, and family studies of schizophrenia: behavioral genetic perspectives. Schizophrenia Bull 2:360–401.CrossRefGoogle Scholar
10.Gottesman, II, Shields, J (1977): Twin studies and schizophrenia a decade later. In Maher, BA (ed): Contributions to the Psychopathology of Schizophrenia. New York: Academic Press.Google Scholar
11.Gottesman, II, Shields, J, Hanson, DR (1982): Schizophrenia. The Epigenetic Puzzle. New York: Cambridge University Press.Google Scholar
12.Gralnick, A (1942): Folie a deux -The psychosis of association. Psychiat Quart 16:230–320.Google Scholar
13.Jonsson, AE, Nilsson, T (1968): Alkohol konsumption hos monozygote och dizygota tvillingar. Nord Hyg Tidskr 49:21–25.Google Scholar
14.Kaij, L (1960): Alcoholism in Twins. Stockholm: Almqist and Wiksel.Google Scholar
15.Kallmann, FJ (1946): The genetic theory of schizophrenia: An analysis of 691 schizophrenic twin index families. Am J Psychiatry 103:309–322.CrossRefGoogle ScholarPubMed
16.Kaprio, J, Sarna, S, Koskenvuo, M, Rantasalo, I (1978): The Finnish Twin Registry: Baseline Characteristics: Section II. Helsinki: Publications of the Department of Public Health Science M37.Google Scholar
17.Kaprio, J, Sarna, S, Koskenvuo, M, Rantasalo, I (1978): The Finnish Twin Registry: Formation and complication, questionnaire study, zygosity determination procedures and research program. Prog Clin Biol Res 24B:179–184.Google Scholar
18.Kaprio, J, Koskenvuo, M, Artimo, M, Sarna, S, Rantasalo, I (1979): The Finnish Twin Registry: Baseline characteristics: Section I. Helsinki: Publications of the Department of Public Health Science M47.Google Scholar
19.Kaprio, J, Hammar, N, Koskenvuo, M, Floderus-Myrhed, B, Langinvainio, H, Sarna, S (1982): Cigarette smoking and alcohol use in Finland and Sweden: A cross-national twin study. Int J Epid 11:378–386.CrossRefGoogle ScholarPubMed
20.Koskenvuo, M, Langinvainio, H, Kaprio, J, Rantasalo, I, Sarna, S (1979): The Finnish Twin Registry: Baseline Characteristics: Section III. Helsinki, Publications of the Department of Public Health Science M49.Google Scholar
21.Koskenvuo, M, Langinvainio, H, Kaprio, J, Sarna, S (1984): Health related psychosocial correlates of neuroticism, a study of adult male twins in Finland. Acta Genet Med Gemellol 33:307–320.Google ScholarPubMed
22.Kringlen, E (1967): Heredity and Environment in the Functional Psychoses. London: Heinemann.Google Scholar
23.Luchins, DJ, Weinberger, DR, Wyatt, RJ (1982): Schizophrenia and cerebral asymmetry detected by computed Tomography. Am J Psychiatry 139:753–757.Google Scholar
24.Luxenburger, H (1928): Vorläufiger bericht über psychiatrische Serienuntersuchungen an Zwillinge. Z Gesamte Neurol Psychiatr 116:297–326.Google Scholar
25.Partanen, J, Bruun, K, and Markkanen, K (1966): Inheritance of Drinking Behavior. Helsinki: The Finnish Foundation of Alcohol Studies.Google Scholar
26.Poikolainen, K (1982): Accuracy of Finnish hospital discharge data: five alcohol-related diseases. (English summary). Duodecim 98:461–467.Google Scholar
27.Pollin, W, Allen, MG, Hoffer, A, Stabenau, JR, Hrubec, Z (1969): Psychopathology in 15,909 pairs of veteran twins. Am J Psychiatry 126:597–609.CrossRefGoogle Scholar
28.Reveley, AM, Reveley, AR, Clifford, CA, Murray, RM (1982): Cerebral ventricular size in twins discordant for schizophrenia. Lancet i: 540:541.Google Scholar
29.Rosanoff, AJ, Hardy, LM, Plesset, IR, Brush, S (1934): The etiology of so called schizophrenic psychoses. Am J Psychiatry 91:247–286.Google Scholar
30.Sarna, S, Kaprio, J, Sistonen, P and Koskenvuo, M (1978): Diagnosis of twin zygosity by mailed questionnaire. Hum Hered 28:241–254.Google Scholar
31.Sarna, S and Kaprio, J (1980): Use of multiple logistic analysis in twin zygosity diagnosis. Hum Hered 30:71–80.Google Scholar
32.Scharfetter, C (1972): Studies on heredity in symbiontic psychoses. Int J Ment Health 1:116–123.Google Scholar
33.Siemon, M (1980): The separation-individuation process in adult twins. Am J Psychother 34:387–400.CrossRefGoogle ScholarPubMed
34.Slater, E (1953): Psychotic and neurotic illnesses in twins. Spec Rep Ser Med Res Counc (London) 278–385.Google Scholar
35.Tienari, P (1963): Psychiatric illness in identical twins. Acta Psychiatr Scand 39: Suppl 171.Google Scholar
36.Tienari, P (1971): Schizophrenia and monozygotic twins. Psychiatrica Fennica: 97–104.Google Scholar
37.Tienari, P (1975): Schizophrenia in Finnish male twins. Ed. MH Lader: Studies of Schizophrenia. London, Br J Psychiatry Spec Publ No. 10.Google Scholar
38.Torgersen, S (1980): The genetics of depressive neurosis. Ed. Achte, K, Aalberg, V and Lönnqvist, J: Psychopathology of depression, Helsinki, Psychiatrica Fennica: Suppl.Google Scholar