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Feline immunodeficiency virus diagnosis after vaccination

Published online by Cambridge University Press:  28 February 2007

Philip R. Andersen  and
Phyllis Tyrrell
Philip R. Andersen*
Affiliation:
IDEXX Laboratories Inc., One IDEXX Drive, Westbrook, ME 04092, USA
Phyllis Tyrrell
Affiliation:
IDEXX Laboratories Inc., One IDEXX Drive, Westbrook, ME 04092, USA
*
*E-mail: phil-andersen@idexx.com
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Abstract

Prior to the widespread use of vaccination for the control of feline immunodeficiency virus (FIV) infection, diagnosis was made by the detection of antibodies against FIV. A number of commercial animal side tests perform quite well for this determination, with positive predictive values between 91 and 100% and negative predictive values between 96 and 100%. Furthermore, results of these tests could be confirmed by western blot analysis of FIV test-positive sera. Currently, a killed whole virus FIV vaccine has been made available to practitioners. Vaccinated cats seroconvert by ELISA and western blot, making presently available diagnostic tests, which rely on antibody detection, useless in cats after vaccination. The advisory panels of the American Association of Feline Practitioners and Academy of Feline Medicine both recommend testing for feline leukemia virus antigen and FIV antibody before vaccination.

Keywords

feline immunodeficiency virusdiagnosisvaccinationcats
Type
Research Article
Information
Animal Health Research Reviews , Volume 5 , Issue 2 , December 2004 , pp. 327 - 330
Copyright
Copyright © CAB International 2004

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