Hostname: page-component-78c5997874-8bhkd Total loading time: 0 Render date: 2024-11-05T16:17:16.267Z Has data issue: false hasContentIssue false
  • English
  • Français

Feline immunodeficiency virus diagnosis after vaccination

Published online by Cambridge University Press:  28 February 2007

Philip R. Andersen  and
Phyllis Tyrrell
Philip R. Andersen*
Affiliation:
IDEXX Laboratories Inc., One IDEXX Drive, Westbrook, ME 04092, USA
Phyllis Tyrrell
Affiliation:
IDEXX Laboratories Inc., One IDEXX Drive, Westbrook, ME 04092, USA
*
*E-mail: phil-andersen@idexx.com
Get access Rights & Permissions [Opens in a new window]

Abstract

Prior to the widespread use of vaccination for the control of feline immunodeficiency virus (FIV) infection, diagnosis was made by the detection of antibodies against FIV. A number of commercial animal side tests perform quite well for this determination, with positive predictive values between 91 and 100% and negative predictive values between 96 and 100%. Furthermore, results of these tests could be confirmed by western blot analysis of FIV test-positive sera. Currently, a killed whole virus FIV vaccine has been made available to practitioners. Vaccinated cats seroconvert by ELISA and western blot, making presently available diagnostic tests, which rely on antibody detection, useless in cats after vaccination. The advisory panels of the American Association of Feline Practitioners and Academy of Feline Medicine both recommend testing for feline leukemia virus antigen and FIV antibody before vaccination.

Keywords

feline immunodeficiency virusdiagnosisvaccinationcats
Type
Research Article
Information
Animal Health Research Reviews , Volume 5 , Issue 2 , December 2004 , pp. 327 - 330
Copyright
Copyright © CAB International 2004

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Celer, V, Kulhankova, H Jr and Celer, V (2000). Detection of feline immunodeficiency provirus by seminested polymerase chain reaction. Folia Microbiologica 45: 161–165.CrossRefGoogle ScholarPubMed
Dandekar, S, Beebe, AM, Barlough, J, Phillips, T, Elder, J, Torten, M and Pedersen, N (1992). Detection of feline immunodeficiency virus (FIV) nucleic acids in FIV seronegative cats. Journal of Virology 66: 4040–4049.CrossRefGoogle ScholarPubMed
Diehl, LJ, Mathiason-DuBard, CK, O'Neil, LL and Hoover, EA (1995). Longitudinal assessment of feline immunodeficiency virus kinetics in plasma by use of a quantitative competitive reverse transcriptase PCR. Journal of Virology 69: 2328–2332.CrossRefGoogle ScholarPubMed
Klein, D, Janda, P, Steinborn, R, Muller, M, Salmons, B and Gunzburg, WH (1999). Proviral load determination of different feline immunodeficiency virus isolates using real-time polymerase chain reaction: influence of mismatches on quantification. Electrophoresis 20: 291–299.3.0.CO;2-R>CrossRefGoogle ScholarPubMed
Lawson, M, Meers, J, Blechynden, L, Robinson, W, Greene, W and Carnegie, P (1993). The detection and quantification of feline immunodeficiency provirus in peripheral blood mononuclear cells using the polymerase chain reaction. Veterinary Microbiology 38: 11–21.CrossRefGoogle ScholarPubMed
Leutenegger, CM, Klein, D, Hofmann-Lehmann, R, Mislin, C, Hummel, U, Boni, J, Boretti, F, Guenzburg, WH and Lutz, H (1999). Rapid feline immunodeficiency virus provirus quantitation by polymerase chain reaction using the TaqMan fluorogenic real-time detection system. Journal of Virological Methods 78: 105–116.Google Scholar
O'Neil, LL, Burkhard, MJ, Obert, LA and Hoover, EA (1997). Regression of feline immunodeficiency virus infection. AIDS Research Human Retroviruses 13: 713–718.Google Scholar
Pyra, H, Boni, J and Schupbach, J (1994). Ultrasensitive retrovirus detection by a reverse transcriptase assay based on product enhancement. Proceedings of the National Academy of Sciences of the United States of America 91: 1544–1548.CrossRefGoogle ScholarPubMed
Schechter, MT, Neumann, PW, Weaver, MS, Montaner, JS, Cassol, SA, Le, TN, Craib, KJ, O'Shaughnessy, MV (1991). Low HIV-1 proviral DNA burden detected by negative polymerase chain reaction in seropositive individuals correlates with slower disease progression. AIDS 5: 373–379.CrossRefGoogle ScholarPubMed
Vahlenkamp, TW, Egberink, HF, van Eijk, MJ, Slotboom-Kamphorst, AM, Verschoor, EJ, Horzinek, MC and de Ronde, A (1995). Competitive reverse transcriptase–polymerase chain reaction for quantitation of feline immunodeficiency virus. Journal of Virological Methods 52: 335–336.CrossRefGoogle Scholar