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Update on bacterial pathogenesis in BRD

Published online by Cambridge University Press:  15 December 2009

Anthony W. Confer
Anthony W. Confer*
Affiliation:
Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK 74078-2007, USA
*
E-mail: anthony.confer@okstate.edu
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Abstract

Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, Mycoplasma bovis and Arcanobacterium pyogenes are all frequently implicated in bovine respiratory disease (BRD). M. haemolytica is considered the most important of the group. These bacteria are commensals in the nasopharynx and establish infection in the lungs of cattle that are subjected to a variety of stresses. Factors that permit adherence to and proliferation in the lungs and factors that cause tissue destruction and inflammation have been identified as having major roles in pathogenesis. These virulence factors include protein adhesins, capsular polysaccharide, outer membrane proteins, iron-binding proteins, lipopolysacharide or lipooligosaccharide, enzymes and toxins. These bacterial products function to evade the immune system, damage the immune system and induce a severe inflammatory response.

Keywords

Mannheimia haemolyticaPasteurella multocidaHistophilus somniArcanobacterium pyogenesBibersteinia trehalosiMycoplasma bovis
Type
Review Article
Information
Animal Health Research Reviews , Volume 10 , Issue 2 , December 2009 , pp. 145 - 148
Copyright
Copyright © Cambridge University Press 2009

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