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Effects of resistant starch on behaviour, satiety-related hormones and metabolites in growing pigs

Published online by Cambridge University Press:  20 May 2014

C. Souza da Silva ,
D. Haenen ,
S. J. Koopmans ,
G. J. E. J. Hooiveld ,
G. Bosch ,
J. E. Bolhuis ,
B. Kemp ,
M. Müller  and
W. J. J. Gerrits
C. Souza da Silva*
Affiliation:
Adaptation Physiology Group, Wageningen University, P.O. Box 338, 6700 AH, Wageningen, The Netherlands Animal Nutrition Group, Wageningen University, P.O. Box 338, 6700 AH, Wageningen, The Netherlands
D. Haenen
Affiliation:
Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD, Wageningen, The Netherlands
S. J. Koopmans
Affiliation:
Adaptation Physiology Group, Wageningen University, P.O. Box 338, 6700 AH, Wageningen, The Netherlands
G. J. E. J. Hooiveld
Affiliation:
Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD, Wageningen, The Netherlands
G. Bosch
Affiliation:
Animal Nutrition Group, Wageningen University, P.O. Box 338, 6700 AH, Wageningen, The Netherlands
J. E. Bolhuis
Affiliation:
Adaptation Physiology Group, Wageningen University, P.O. Box 338, 6700 AH, Wageningen, The Netherlands
B. Kemp
Affiliation:
Adaptation Physiology Group, Wageningen University, P.O. Box 338, 6700 AH, Wageningen, The Netherlands
M. Müller
Affiliation:
Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Bomenweg 2, 6703 HD, Wageningen, The Netherlands
W. J. J. Gerrits
Affiliation:
Animal Nutrition Group, Wageningen University, P.O. Box 338, 6700 AH, Wageningen, The Netherlands
*
†E-mail: carol.souza@live.nl
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Abstract

Resistant starch (RS) has been suggested to prolong satiety in adult pigs. The present study investigated RS-induced changes in behaviour, satiety-related hormones and metabolites in catheterized growing pigs to explore possible underlying mechanisms for RS-induced satiety. In a cross-over design with two 14-day periods, 10 pigs (initial BW: 58 kg) were assigned to two treatments comprising diets containing either 35% pregelatinized starch (PS) or 34% retrograded starch (RS). Diets were isoenergetic on gross energy. Pigs were fed at 2.8× maintenance. Postprandial plasma response of satiety-related hormones and metabolites was measured at the end of each period using frequent blood sampling. Faecal and urinary energy losses were measured at the end of each period. Behaviour was scored 24 h from video recordings using scan sampling. Energy digestibility and metabolizability were ~6% lower in RS compared with PS diet (P<0.001), and metabolizable energy (ME) intake was ~3% lower in RS-fed than in PS-fed pigs (P<0.001). RS-fed pigs showed less feeder-directed (P=0.001) and drinking (P=0.10) behaviours than PS-fed pigs throughout the day. Postprandial peripheral short-chain fatty acid (SCFA) levels were higher in RS-fed than in PS-fed pigs (P<0.001). Postprandial glucose and insulin responses were lower in RS-fed than in PS-fed pigs (P<0.001). Triglyceride levels were higher in RS-fed than in PS-fed pigs (P<0.01), and non-esterified fatty acid levels did not differ between diets (P=0.90). Glucagon-like peptide-1 (GLP-1) levels were lower in RS-fed than in PS-fed pigs (P<0.001), and peptide tyrosine tyrosine (PYY) levels did not differ between diets (P=0.90). Blood serotonin levels were lower (P<0.001), whereas monoamine oxidase activity (P<0.05) and tryptophan (P<0.01) levels were higher in RS-fed than in PS-fed pigs. Despite a lower ME intake, RS seemed to prolong satiety, based on behavioural observations. Possible underlying mechanisms for RS-induced satiety include increased 24 h plasma SCFA levels, and decreased postprandial glucose and insulin responses. GLP-1 and PYY seemed not to play a role in RS-induced satiety. Low blood serotonin levels in RS-fed pigs suggested a difference in intestinal serotonin release between treatments. Increased postprandial plasma triglyceride levels corresponded with increased SCFA levels, but it is unclear whether triglycerides may have signalled satiety in RS-fed pigs.

Keywords

hungerphysical activitypigsresistant starchsatiety-related hormones
Type
Research Article
Information
animal , Volume 8 , Issue 9 , September 2014 , pp. 1402 - 1411
Copyright
© The Animal Consortium 2014 

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