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Meta-analysis of phosphorus utilization by growing pigs: effect of dietary phosphorus, calcium and exogenous phytase

Published online by Cambridge University Press:  16 March 2012

M. P. Létourneau-Montminy ,
C. Jondreville ,
D. Sauvant  and
A. Narcy
M. P. Létourneau-Montminy
Affiliation:
Dairy and Swine Research and Development Centre, Agriculture and Agri-Food Canada, Sherbrooke, Quebec J1M 1Z3, Canada
C. Jondreville
Affiliation:
INRA, Nancy-Université, USC 340 Animal et Fonctionnalités des Produits Animaux, F-54500 Vandoeuvre-lès-Nancy, France
D. Sauvant
Affiliation:
INRA, AgroParisTech, UMR791 Physiologie de la Nutrition et Alimentation, F-75231 Paris, France
A. Narcy*
Affiliation:
INRA, UR83 Recherches Avicoles, F-37380 Nouzilly, France
*
†E-mail: anarcy@tours.inra.fr
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Abstract

Optimizing phosphorus (P) utilization in pigs requires improving our capacity to predict the amount of P absorbed and retained, with the main modulating factors taken into account, as well as precisely determining the P requirements of the animals. Given the large amount of published data on P utilization in pigs, a meta-analysis was performed to quantify the impact of the different dietary P forms, calcium (Ca) and exogenous phytases on the digestive and metabolic utilization criteria for dietary P in growing pigs. Accordingly, the amount of phytate P (PP) leading to digestible P (g/kg) was estimated to be 21%, compared with 73% for non-phytate P (NPP) from plant ingredients and 80% for NPP from mineral and animal ingredients (P < 0.001). The increase in total digestible dietary P following the addition of microbial phytase (PhytM) from Aspergillus niger (P < 0.001) was curvilinear and about two times higher than the increase following the addition of plant phytase, which leads to a linear response (P < 0.001). The response of digestible P to PhytM also depends on the amount of substrate, PP (PhytM2 × PP, P < 0.001). The digestibility of dietary P decreased with dietary Ca concentration (P < 0.01) independently of phytase but increased with body weight (BW, P < 0.05). Although total digestible dietary P increased linearly with total NPP concentration (P < 0.001), retained P (g/kg), average daily gain (ADG, g/day) and average daily feed intake (ADFI, g/day) increased curvilinearly (P < 0.001). Interestingly, whereas dietary Ca negatively affected P digestibility, the effect of dietary Ca on retained P, ADG and ADFI depended on total dietary NPP (NPP × Ca, P < 0.01, P < 0.05 and P < 0.01, respectively). Increasing dietary Ca reduced retained P, ADG and ADFI at low NPP levels, but at higher NPP concentrations it had no effect on ADG and ADFI despite a positive effect on retained P. Although the curvilinear effect of PhytM on digestible P increased with PP (P < 0.001), this effect was lessened by total NPP for ADG and ADFI (PhytM × NPP and PhytM2 × NPP, P < 0.05) and depended on both total NPP and Ca for retained P (PhytM2 × NPP × Ca, P < 0.01). This meta-analysis improves our understanding of P utilization, with major modulating factors taken into account. The information generated will be useful for the development of robust models to formulate environmentally friendly diets for growing pigs.

Keywords

calciumgrowing pigsmeta-analysisphosphorusphytase
Type
Full Paper
Information
animal , Volume 6 , Issue 10 , October 2012 , pp. 1590 - 1600
Copyright
Copyright © The Animal Consortium 2012

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References

Adeola, O, Olukosi, OA, Jendza, JA, Dilger, RN, Bedford, MR 2006. Response of growing pigs to Peniophora lycii- and Escherichia coli-derived phytases or varying ratios of calcium to total phosphorus. Animal Science 82, 637–644.CrossRefGoogle Scholar
Akinmusire, AS, Adeola, O 2009. True digestibility of phosphorus in canola and soybean meals for growing pigs: influence of microbial phytase. Journal of Animal Science 87, 977–983.CrossRefGoogle ScholarPubMed
Alebrante, L, Donzele, JL, Oliveira, RF, Saraiva, A, Guimarães, SEF, Ferreira, AS 2011. Available phosphorus levels in diets for pigs with high genetic potential for lean meat deposition kept in thermoneutral environment from 15 to 30 kg. Revista Brasileira de Zootecnia 40, 323–330.CrossRefGoogle Scholar
Barrier-Guillot, B, Casado, P, Maupetit, P, Jondreville, C, Gatel, F, Larbier, M 1996. Wheat phosphorus availability. 2. In vivo study in broilers and pigs; relationship with endogenous phytasic activity and phytic phosphorus content in wheat. Journal of the Science of Food and Agriculture 70, 69–74.3.0.CO;2-C>CrossRefGoogle Scholar
Bayley, HS, Summers, JD 1975. Nutritional evaluation of extruded full-fat soybeans and rapeseeds using pigs and chickens. Canadian Journal of Animal Science 55, 441–450.CrossRefGoogle Scholar
Beaulieu, AD, Bedford, MR, Patience, JF 2007. Supplementing corn or corn–barley diets with an E. coli derived phytase decreases total and soluble P output by weanling and growing pigs. Canadian Journal of Animal Science 87, 353–364.CrossRefGoogle Scholar
Bohlke, RA, Thaler, RC, Stein, HH 2005. Calcium, phosphorus, and amino acid digestibility in low-phytate corn, normal corn, and soybean meal by growing pigs. Journal of Animal Science 83, 2396–2403.CrossRefGoogle ScholarPubMed
Bruce, JAM, Sundstøl, F 1995. The effect of microbial phytase in diets for pigs on apparent ileal and faecal digestibility, pH and flow of digesta measurements in growing pigs fed high-fibre diet. Canadian Journal of Animal Science 75, 121–127.CrossRefGoogle Scholar
Calvert, CC, Besecker, RJ, Plumlee, MP, Cline, TR, Forsyth, DM 1978. Apparent digestibility of phosphorous in barley and corn for growing swine. Journal of Animal Science 47, 420–426.CrossRefGoogle Scholar
Crenshaw, TD 2001. Calcium, phosphorus, vitamin D, and vitamin K in swine nutrition. In Swine nutrition (ed. AJ Lewis and LL Southern), 2nd edition, pp. 187–212. CRC Press, Boca Raton, FL.Google Scholar
Cromwell, GL, Coffey, RD, Monegue, HJ, Randolph, JH 1995. Efficacy of low-activity, microbial phytase in improving the bioavailability of phosphorus in corn–soybean meal diets for pigs. Journal of Animal Science 73, 449–456.CrossRefGoogle ScholarPubMed
Dilger, RN, Adeola, O 2006. Estimation of true phosphorus digestibility and endogenous phosphorus loss in growing pigs fed conventional and low-phytate soybean meals. Journal of Animal Science 84, 627–634.CrossRefGoogle ScholarPubMed
Driver, JP, Pesti, GM, Bakalli, RI, Edwards, HD Jr 2005. Effects of calcium and nonphytate phosphorus concentrations on phytase efficacy in broiler chicks. Poultry Science 84, 1406–1417.CrossRefGoogle ScholarPubMed
Düngelhoef, M, Rodehutscord, M, Spiekers, H, Pfeffer, E 1994. Effects of supplemental microbial phytase on availability of phosphorus contained in maize, wheat and triticale to pigs. Animal Feed Science and Technology 49, 1–10.CrossRefGoogle Scholar
Eeckhout, W, De Paepe, M 1992. Phytase de blé, phytase microbienne et digestibilité apparente du phosphore d'un aliment simple pour porcelets. Revue de l'Agriculture 45, 195–207.Google Scholar
Ekpe, ED, Zijlstra, RT, Patience, JF 2002. Digestible phosphorus requirement of grower pigs. Canadian Journal of Animal Science 82, 541–549.CrossRefGoogle Scholar
Guggenbuhl, P, Simões Nunes, C 2007. Effects of two phytases on the ileal apparent digestibility of minerals and amino acids in ileo-rectal anastomosed pigs fed on a maize–rapeseed meal diet. Livestock Science 109, 261–263.CrossRefGoogle Scholar
Harper, AF, Kornegay, ET, Schell, TC 1997. Phytase supplementation of low-phosphorus growing–finishing pig diets improves performance, phosphorus digestibility, and bone mineralization and reduces phosphorus excretion. Journal of Animal Science 75, 3174–3186.CrossRefGoogle ScholarPubMed
Heaney, RP, Nordin, BEC 2002. Calcium effects on phosphorus absorption: implications for the prevention and co-therapy of osteoporosis. Journal of the American College of Nutrition 21, 239–244.CrossRefGoogle ScholarPubMed
Hill, BE, Sutton, AL, Richert, BT 2009. Effects of low-phytic acid corn, low-phytic acid soybean meal, and phytase on nutrient digestibility and excretion in growing pigs. Journal of Animal Science 87, 1518–1527.CrossRefGoogle ScholarPubMed
Htoo, JK, Sauer, WC, Yáñez, YL, Cervantes, M, Zhang, Y, Helm, JH, Zijlstra, RT 2007. Effect of low-phytate barley or phytase supplementation to a barley–soybean meal diet on phosphorus retention and excretion by grower pigs. Journal of Animal Science 85, 2941–2948.CrossRefGoogle ScholarPubMed
Hu, HL, Wise, A, Henderson, C 1996. Hydrolysis of phytate and inositol tri-, tetra-, and penta-phosphates by the intestinal mucosa of the pig. Nutrition Research 16, 781–787.CrossRefGoogle Scholar
Jendza, JA, Dilger, RN, Sands, JS, Adeola, O 2006. Efficacy and equivalency of an Escherichia coli-derived phytase for replacing inorganic phosphorus in the diets of broiler chickens and young pigs. Journal of Animal Science 84, 3364–3374.CrossRefGoogle ScholarPubMed
Jendza, JA, Dilger, RN, Adedokun, SA, Sands, JS, Adeola, O 2005. Escherichia coli phytase improves growth performance of starter, grower, and finisher pigs fed phosphorus-deficient diets. Journal of Animal Science 83, 1882–1889.CrossRefGoogle ScholarPubMed
Johnston, SL, Williams, SB, Southern, LL, Bidner, TD, Bunting, LD, Matthews, JO, Olcott, BM 2004. Effect of phytase addition and dietary calcium and phosphorus levels on plasma metabolites and ileal and total-tract nutrient digestibility in pigs. Journal of Animal Science 82, 705–714.CrossRefGoogle ScholarPubMed
Jongbloed, AW, Kemme, PA 1990. Effect of pelleting mixed feeds on phytase activity and the apparent absorbability of phosphorus and calcium in pigs. Animal Feed Science and Technology 28, 233–242.CrossRefGoogle Scholar
Jongbloed, AW, Mroz, Z, Kemme, PA 1992. The effect of supplementary Aspergillus niger phytase in diets for pigs on concentration and apparent digestibility of dry matter, total phosphorus, and phytic acid in different sections of the alimentary tract. Journal of Animal Science 70, 1159–1168.CrossRefGoogle ScholarPubMed
Jongbloed, AW, Kemme, PA, Mroz, Z 1996. Effectiveness of Natuphos phytase in improving the bioavailabilities of phosphorus and other nutrients for growing–finishing pigs. In Phytase in animal nutrition and waste management (ed. MB Coelho and ET Kornegay), pp. 259–274. BASF Corporation, Mount Olive, NJ.Google Scholar
Jongbloed, AW, Mroz, Z, van der Weij-Jongbloed, R, Kemme, PA 2000. The effects of microbial phytase, organic acids and their interaction in diets for growing pigs. Livestock Production Science 67, 113–122.CrossRefGoogle Scholar
Kemme, PA 1998. Phytate and phytases in pig nutrition. Impact on nutrient digestibility and factors affecting phytase efficacy. PhD, University of Wageningen.Google Scholar
Kemme, PA, Jongbloed, AW, Mroz, Z, Beynen, AC 1997a. The efficacy of Aspergillus niger phytase in rendering phytate phosphorus available for absorption in pigs is influenced by pig physiological status. Journal of Animal Science 75, 2129–2138.CrossRefGoogle ScholarPubMed
Kemme, PA, Radcliffe, JS, Jongbloed, AW, Mroz, Z 1997b. Factors affecting phosphorus and calcium digestibility in diets for growing–finishing pigs. Journal of Animal Science 75, 2139–2146.CrossRefGoogle ScholarPubMed
Kemme, PA, Schlemmer, U, Mroz, Z, Jongbloed, AW 2006. Monitoring the stepwise phytate degradation in the upper gastrointestinal tract of pigs. Journal of the Science of Food and Agriculture 86, 612–622.CrossRefGoogle Scholar
Kemme, PA, Jongbloed, AW, Mroz, Z, Kogut, J, Beynen, AC 1999a. Digestibility of nutrients in growing–finishing pigs is affected by Aspergillus niger phytase, phytate and lactic acid levels: 1. Apparent ileal digestibility of amino acids. Livestock Production Science 58, 107–117.CrossRefGoogle Scholar
Kemme, PA, Jongbloed, AW, Mroz, Z, Kogut, J, Beynen, AC 1999b. Digestibility of nutrients in growing–finishing pigs is affected by Aspergillus niger phytase, phytate and lactic acid levels: 2. Apparent total tract digestibility of phosphorus, calcium and magnesium and ileal degradation of phytic acid. Livestock Production Science 58, 119–127.CrossRefGoogle Scholar
Ketaren, PP, Batterham, ES, Dettmann, EB, Farrell, DJ 1993. Phosphorus studies in pigs. 3. Effect of phytase supplementation on the digestibility and availability of phosphorus in soya-bean meal for grower pigs. British Journal of Nutrition 70, 289–311.CrossRefGoogle ScholarPubMed
Kidder, DE, Manners, MJ 1978. Digestion in the pig. Kingston Press, Bath, UK.Google Scholar
Kies, AK, Kemme, PA, Sebek, LBJ, van Diepen, JTM, Jongbloed, AW 2006. Effect of graded doses and a high dose of microbial phytase on the digestibility of various minerals in weaner pigs. Journal of Animal Science 84, 1169–1175.CrossRefGoogle Scholar
Kim, JC, Simmins, PH, Mullan, BP, Pluske, JR 2005. The effect of wheat phosphorus content and supplemental enzymes on digestibility and growth performance of weaner pigs. Animal Feed Science and Technology 118, 139–152.CrossRefGoogle Scholar
Kim, JC, Sands, JS, Mullan, BP, Pluske, JR 2008. Performance and total-tract digestibility responses to exogenous xylanase and phytase in diets for growing pigs. Animal Feed Science and Technology 142, 163–172.CrossRefGoogle Scholar
Kornegay, ET, Qian, H 1996. Replacement of inorganic phosphorus by microbial phytase for young pigs fed on a maize–soyabean-meal diet. British Journal of Nutrition 76, 563–578.CrossRefGoogle ScholarPubMed
Kornegay, ET, Radcliffe, JS, Zhang, Z 1998. Influence of phytase and diet composition on phosphorus and amino acid digestibilities, and phosphorus and nitrogen excretion in swine. BASF Technology Symposium, Mount Olive, NJ, pp. 125–155.Google Scholar
Lantzsch, HJ, Wjst, S, Drochner, W 1995. The effect of dietary calcium on the efficacy of microbial phytase in rations for growing pigs. Journal of Animal Physiology and Animal Nutrition 73, 19–26.CrossRefGoogle Scholar
Laplace, JP, Aumaitre, A, Rerat, A 2001. Forty years of achievement in French research on digestive physiology in the pig. Reproduction Nutrition Development 41, 129–151.CrossRefGoogle ScholarPubMed
Larsen, T, Sandström, B 1993. Effect of dietary calcium level on mineral and trace element utilization from a rapeseed (Brassica napus L.) diet fed to ileum-fistulated pigs. British Journal of Nutrition 69, 211–224.CrossRefGoogle ScholarPubMed
Lei, XG, Ku, PK, Miller, ER, Yokoyama, MT 1993a. Supplementing corn–soybean meal diets with microbial phytase linearly improves phytate phosphorus utilization by weanling pigs. Journal of Animal Science 71, 3359–3367.CrossRefGoogle ScholarPubMed
Lei, XG, Ku, PK, Miller, ER, Yokoyama, MT, Ullrey, DE 1993b. Supplementing corn–soybean meal diets with microbial phytase maximizes phytate phosphorus utilization by weanling pigs. Journal of Animal Science 71, 3368–3375.CrossRefGoogle ScholarPubMed
Létourneau-Montminy, MP, Narcy, A, Lescoat, P, Bernier, JF, Magnin, M, Pomar, C, Nys, Y, Sauvant, D, Jondreville, C 2010a. Meta-analysis of phosphorus utilisation by broilers receiving corn–soyabean meal diets: influence of dietary calcium and microbial phytase. Animal 4, 1844–1853.CrossRefGoogle ScholarPubMed
Létourneau-Montminy, MP, Narcy, A, Magnin, M, Sauvant, D, Bernier, JF, Pomar, C, Jondreville, C 2010b. Effect of reduced dietary calcium concentration and phytase supplementation on calcium and phosphorus utilization in weaned piglets with modified mineral status. Journal of Animal Science 88, 1706–1717.CrossRefGoogle Scholar
Létourneau-Montminy, MP, Narcy, A, Lescoat, P, Magnin, M, Bernier, JF, Sauvant, D, Jondreville, C, Pomar, C 2011. Modeling the fate of dietary phosphorus in the digestive tract of growing pigs. Journal of Animal Science 89, 3596–3611.CrossRefGoogle ScholarPubMed
Liu, J, Bollinger, DW, Ledoux, DR, Ellersieck, MR, Veum, TL 1997. Soaking increases the efficacy of supplemental microbial phytase in a low-phosphorus corn–soybean meal diet for growing pigs. Journal of Animal Science 75, 1292–1298.CrossRefGoogle Scholar
Lyberg, K, Simonsson, A, Lindberg, JE 2005. Influence of phosphorus level and soaking of food on phosphorus availability and performance in growing–finishing pigs. Animal Science 81, 375–381.CrossRefGoogle Scholar
Maxson, PF, Mahan, DC 1983. Dietary calcium and phosphorus levels for growing swine from 18 to 57 kilograms body weight. Journal of Animal Science 56, 1124–1134.CrossRefGoogle ScholarPubMed
Mroz, Z, Jongbloed, AW, Kemme, PA 1994. Apparent digestibility and retention of nutrients bound to phytate complexes as influenced by microbial phytase and feeding regimen in pigs. Journal of Animal Science 72, 126–132.CrossRefGoogle ScholarPubMed
Murry, AC 1995. Effect of microbial phytase on calcium and phosphorus digestibility and serum mineral concentrations in growing and finishing pigs. The University of Georgia Animal and Dairy Science Annual Report.Google Scholar
Narcy, A, Létourneau-Montminy, MP, Bouzouagh, E, Même, N, Magnin, M, Dourmad, JY 2010. Effect of dietary calcium concentration and microbial phytase addition on P utilisation in weaned pigs. Journal of Animal Science 88 (Suppl. 2), 861–862.Google Scholar
Olukosi, OA, Sands, JS, Adeola, O 2007. Supplementation of carbohydrases or phytase individually or in combination to diets for weanling and growing–finishing pigs. Journal of Animal Science 85, 1702–1711.CrossRefGoogle ScholarPubMed
O'Quinn, PR, Knabe, DA, Gregg, EJ 1997a. Digestible phosphorus needs of terminal-cross growing–finishing pigs. Journal of Animal Science 75, 1308–1318.CrossRefGoogle ScholarPubMed
O'Quinn, PR, Knabe, DA, Gregg, EJ 1997b. Efficacy of Natuphos in sorghum-based diets of finishing swine. Journal of Animal Science 75, 1299–1307.CrossRefGoogle ScholarPubMed
Pallauf, J, Rimbach, G, Pippig, S, Schindler, B, Most, E 1994. Effect of phytase supplementation to a phytate-rich diet based on wheat, barley and soya on the bioavailability of dietary phosphorus, calcium, magnesium, zinc and protein in piglets. Agribiology Research 47, 39–48.Google Scholar
Phillippy, BQ 1999. Susceptibility of wheat and Aspergillus niger phytases to inactivation by gastrointestinal enzymes. Journal of Agricultural Food Chemistry 47, 1385–1388.CrossRefGoogle ScholarPubMed
Pointillart, A 1991. Enhancement of phosphorus utilization in growing pigs fed phytate-rich diets by using rye bran. Journal of Animal Science 69, 1109–1115.CrossRefGoogle ScholarPubMed
Pointillart, A, Fontaine, N 1983. Effet de deux régimes hypocalcémiants sur la rétention et l'absorption du phosphore et du calcium chez le porc en croissance. Journées de la Recherche Porcine en France 15, 375–384.Google Scholar
Pointillart, A, Fontaine, N, Thomasset, M 1984. Phytate phosphorus utilization and intestinal phosphatases in pigs fed low phosphorus: wheat or corn diets. Nutrition Report International 29, 473–483.Google Scholar
Pointillart, A, Fourdin, A, Delmas, A 1987a. Conséquences néfastes de l'excès de calcium chez des porcs non supplémentés en phosphore minéral. Journées de la Recherche Porcine en France 19, 281–288.Google Scholar
Pointillart, A, Fourdin, A, Fontaine, N 1987b. Importance of cereal phytase activity for phytate phosphorus utilization by growing pigs fed diets containing triticale or corn. Journal of Nutrition 117, 907–913.CrossRefGoogle ScholarPubMed
Pointillart, A, Fontaine, N, Thomasset, M, Jay, ME 1985. Phosphorus utilization, intestinal phosphatases and hormonal control of calcium metabolism in pigs fed phytic phosphorus: soyabean or rapeseed diets. Nutrition Report International 32, 155–167.Google Scholar
Qian, H, Kornegay, ET, Conner, DE Jr 1996. Adverse effects of wide calcium : phosphorus ratios on supplemental phytase efficacy for weanling pigs fed two dietary phosphorus levels. Journal of Animal Science 74, 1288–1297.CrossRefGoogle ScholarPubMed
Radcliffe, JS, Kornegay, ET 1998. Phosphorus equivalency value of microbial phytase in weanling pigs fed a maize–soyabean meal based diet. Journal of Animal Feed Science 7, 197–211.CrossRefGoogle Scholar
Radcliffe, JS, Zhang, Z, Kornegay, ET 1998. The effects of microbial phytase, citric acid, and their interaction in a corn–soybean meal-based diet for weanling pigs. Journal of Animal Scienec 76, 1880–1886.CrossRefGoogle Scholar
Radcliffe, JS, Pleasant, RS, Kornegay, ET 2006. Estimating equivalency values of microbial phytase for amino acids in growing and finishing pigs fitted with steered ileo-cecal valve cannulas. Journal of Animal Science 84, 1119–1129.CrossRefGoogle ScholarPubMed
Rapp, C, Lantzsch, HJ, Drochner, W 2001. Hydrolysis of phytic acid by intrinsic plant or supplemented microbial phytase (Aspergillus niger) in the stomach and small intestine of minipigs fitted with re-entrant cannulas: 1. Passage of dry matter and total phosphorus. Journal of Animal Physiology and Animal Nutrition 85, 406–413.CrossRefGoogle ScholarPubMed
Reinhart, GA, Mahan, DC 1986. Effect of various calcium : phosphorus ratios at low and high dietary phosphorus for starter, grower and finishing swine. Journal of Animal Science 63, 457–466.CrossRefGoogle Scholar
Rodehutscord, M, Faust, M, Pfeffer, E 1999. The course of phosphorus excretion in growing pigs fed continuously increasing phosphorus concentrations after a phosphorus depletion. Arch Tierernähr 52, 323–334.CrossRefGoogle ScholarPubMed
Sandberg, AS, Larsen, T, Sandström, B 1993. High dietary calcium level decreases colonic phytate degradation in pigs fed a rapeseed diet. Journal of Nutrition 123, 559–566.CrossRefGoogle ScholarPubMed
Sands, JS, Ragland, D, Baxter, C, Joern, BC, Sauber, TE, Adeola, O 2001. Phosphorus bioavailability, growth performance, and nutrient balance in pigs fed high available phosphorus corn and phytase. Journal of Animal Science 79, 2134–2142.CrossRefGoogle ScholarPubMed
Sauvant, D, Perez, JM, Tran, G 2004. Tables of composition and nutritional value of feed materials. Institut National de la Recherche Agronomique, Association Française de Zootechnie, Paris, France.CrossRefGoogle Scholar
Sauvant, D, Schmidely, P, Daudin, JJ, St-Pierre, NR 2008. Meta-analyses of experimental data in animal nutrition. Animal 2, 1203–1214.CrossRefGoogle ScholarPubMed
Schindler, B, Lantzsch, HJ, Mosenthin, R, Biesalski, HK, Drochner, W 1997. Dose response effects of microbial phytase on P absorption in growing pigs fed P-reduced diets. Conference at the VII International Symposium on Digestive Physiology in Pigs, Saint Malo, France, pp. 441–445.Google Scholar
Schlemmer, U, Jany, KD, Berk, A, Schulz, E, Rechkemmer, G 2001. Degradation of phytate in the gut of pigs – pathway of gastrointestinal inositol phosphate hydrolysis and enzymes involved. Arch Tierernähr 55, 255–280.CrossRefGoogle ScholarPubMed
Selle, PH, Ravindran, V 2008. Phytate-degrading enzymes in pig nutrition. Livestock Science 113, 99–122.CrossRefGoogle Scholar
Selle, PH, Cowieson, AJ, Ravindran, V 2009. Consequences of calcium interactions with phytate and phytase for poultry and pigs. Livestock Science 124, 126–141.CrossRefGoogle Scholar
Seynaeve, M, Janssens, G, Hesta, M, Van Nevel, C, De Wilde, RO 2000. Effects of dietary Ca/P ratio, P level and microbial phytase supplementation on nutrient digestibilities in growing pigs: precaecal, post-ileal and total tract disappearances of OM, P and Ca. Journal of Animal Physiology and Animal Nutrition 83, 36–48.CrossRefGoogle Scholar
Shirai, K, Revah-Moiseev, S, García-Garibay, M, Marshall, VM 1994. Ability of some strains of lactic acid bacteria to degrade phytic acid. Letter of Applied Microbiology 19, 366–369.CrossRefGoogle Scholar
Skiba, F, Hazouard, I, Bertin, JM, Chauvel, J 2000. Digestibilité du phosphore de 14 matières premières et influence de la phytase végétale dans l'alimentation du porc charcutier. Journées de la Recherche Porcine en France 32, 169–175.Google Scholar
Skiba, F, Callu, P, Castaing, J, Paboeuf, F, Chauvel, J, Jondreville, C 2004. Variabilité intra-matière première de la digestibilité de phosphore des céréales et du pois chez le porc en croissance. Journées de la Recherche Porcine en France 36, 9–16.Google Scholar
Spencer, JD, Allee, GL, Sauber, TE 2000. Phosphorus bioavailability and digestibility of normal and genetically modified low-phytate corn for pigs. Journal of Animal Science 78, 675–681.CrossRefGoogle ScholarPubMed
Sreeramulu, G, Srinivasa, DS, Nand, K, Joseph, R 1996. Lactobacillus amylovorus as a phytase producer in submerged culture. Letter of Applied Microbiology 23, 385–388.CrossRefGoogle Scholar
Stein, HH, Shurson, GC 2009. Board-invited review: the use and applications of distillers dried grains with solubles in swine diets. Journal of Animal Science 87, 1292–1303.CrossRefGoogle Scholar
Stein, HH, Kadzere, CT, Kim, SW, Miller, PS 2008. Influence of dietary phosphorus concentration on the digestibility of phosphorus in monocalcium phosphate by growing pigs. Journal of Animal Science 86, 1861–1867.CrossRefGoogle ScholarPubMed
Steiner, T, Mosenthin, R, Greiner, R 2006. Influence of feeding level and dietary oil supplementation on apparent ileal and total tract digestibilities of phosphorus and calcium in pigs fed low-phosphorus diets supplemented with microbial or wheat phytase. Canadian Journal of Animal Science 86, 479–488.CrossRefGoogle Scholar
Thacker, PA, Rossnagel, BG, Raboy, V 2003. The effects of phytase supplementation on nutrient digestibility, plasma parameters, performance and carcass traits of pigs fed diets based on low-phytate barley without inorganic phosphorus. Canadian Journal of Animal Science 86, 245–254.CrossRefGoogle Scholar
Tonroy, B, Plumlee, MP, Conrad, JH, Cline, TR 1973. Apparent digestibility of the phosphorus in sorghum grain and soybean meal for growing swine. Journal of Animal Science 36, 669–673.CrossRefGoogle Scholar
Underwood, EJ, Suttle, N 2001. The mineral nutrition of livestock, 3rd edition. CABI Publishing, Wallingford, UK.Google Scholar
Veum, TL, Ledoux, DR, Raboy, V, Ertl, DS 2001. Low-phytic acid corn improves nutrient utilization for growing pigs. Journal of Animal Science 79, 2873–2880.CrossRefGoogle ScholarPubMed
Veum, TL, Bollinger, DW, Buff, CE, Bedford, MR 2006. A genetically engineered Escherichia coli phytase improves nutrient utilization, growth performance, and bone strength of young swine fed diets deficient in available phosphorus. Journal of Animal Science 84, 1147–1158.CrossRefGoogle ScholarPubMed
Vipperman, PE, Peo, ER Jr, Cunningham, PJ 1974. Effect of dietary calcium and phosphorus level upon calcium, phosphorus and nitrogen balance in swine. Journal of Animal Science 38, 758–765.CrossRefGoogle ScholarPubMed
Woyengo, TA, Sands, JS, Guenter, W, Nyachoti, CM 2008. Nutrient digestibility and performance responses of growing pigs fed phytase- and xylanase-supplemented wheat-based diets. Journal of Animal Science 86, 848–857.CrossRefGoogle ScholarPubMed
Yi, Z, Kornegay, ET, Ravindran, V, Lindemann, MD, Wilson, JH 1996. Effectiveness of Natuphos phytase in improving the bioavailabilities of phosphorus and other nutrients in soybean meal-based semipurified diets for young pigs. Journal of Animal Science 74, 1601–1611.CrossRefGoogle ScholarPubMed
Zhang, ZB, Kornegay, ET, Radcliffe, JS, Wilson, JH, Veit, HP 2000. Comparison of phytase from genetically engineered Aspergillus and canola in weanling pig diets. Journal of Animal Science 78, 2868–2878.CrossRefGoogle ScholarPubMed
Zimmermann, B, Lantzsch, HJ, Mosenthin, R, Biesalski, HK, Drochner, W 2003. Additivity of the effect of cereal and microbial phytases on apparent phosphorus absorption in growing pigs fed diets with marginal P supply. Animal Feed Science and Technology 104, 143–152.CrossRefGoogle Scholar
Zimmermann, B, Lantzsch, HJ, Mosenthin, R, Schöner, FJ, Biesalski, HK, Drochner, W 2002. Comparative evaluation of the efficacy of cereal and microbial phytases in growing pigs fed diets with marginal phosphorus supply. Journal of the Science of Food and Agriculture 82, 1298–1304.CrossRefGoogle Scholar