Hostname: page-component-78c5997874-lj6df Total loading time: 0 Render date: 2024-11-08T03:32:17.324Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of inflammation stimulation on energy and nutrient utilization in piglets selected for low and high residual feed intake

Published online by Cambridge University Press:  17 June 2015

E. Labussière ,
S. Dubois ,
H. Gilbert ,
J. N. Thibault ,
N. Le Floc’h ,
J. Noblet  and
J. van Milgen
E. Labussière*
Affiliation:
INRA, UMR 1348 Pegase, F-35590 Saint-Gilles, France Agrocampus Ouest, UMR 1348 Pegase, F-35000 Rennes, France
S. Dubois
Affiliation:
INRA, UMR 1348 Pegase, F-35590 Saint-Gilles, France Agrocampus Ouest, UMR 1348 Pegase, F-35000 Rennes, France
H. Gilbert
Affiliation:
INRA, UMR 0444 LGC, INRA Chemin de Borde-Rouge, Auzeville, CS52627, F-31326 Castanet-Tolosan, France
J. N. Thibault
Affiliation:
INRA, UMR 1348 Pegase, F-35590 Saint-Gilles, France Agrocampus Ouest, UMR 1348 Pegase, F-35000 Rennes, France
N. Le Floc’h
Affiliation:
INRA, UMR 1348 Pegase, F-35590 Saint-Gilles, France Agrocampus Ouest, UMR 1348 Pegase, F-35000 Rennes, France
J. Noblet
Affiliation:
INRA, UMR 1348 Pegase, F-35590 Saint-Gilles, France Agrocampus Ouest, UMR 1348 Pegase, F-35000 Rennes, France
J. van Milgen
Affiliation:
INRA, UMR 1348 Pegase, F-35590 Saint-Gilles, France Agrocampus Ouest, UMR 1348 Pegase, F-35000 Rennes, France
*
†E-mail: etienne.labussiere@rennes.inra.fr
Get access

Abstract

Selection of animals for improved feed efficiency can affect sustainability of animal production because the most efficient animals may face difficulties coping with challenges. The objective of this study was to determine the effects of an inflammatory challenge (using an intravenous injection of complete Freund’s adjuvant – CFA) in piglets from two lines of pigs divergently selected during the fattening period for a low (RFI−) or a high (RFI+) residual feed intake (RFI; difference between actual feed intake and theoretical feed requirements). Nitrogen and energy balances (including heat production – HP – and its components: activity-related HP – AHP, thermic effect of feeding, and resting HP) were measured individually in thirteen 20-kg BW castrated male piglets (six and seven from RFI+ and RFI− line, respectively) fed at the same level (1.72 MJ ME/kg BW0.60 per day) from 3 days before to 3 days after CFA injection. Dynamics of dietary U-13C-glucose oxidation were estimated from measurements of 13CO2 production on the day before and 3 days after the CFA injection. Oxidation of dietary nutrients and lipogenesis were calculated based on HP and O2 consumption and CO2 production. The data were analyzed as repeated measurements within piglets in a mixed model. Before CFA injection, RFI− piglets had a lower resting energy expenditure than RFI+ piglets, which tended to increase energy retention because of a higher energy retention as fat. The CFA injection did not affect feed intake from the day following CFA injection onwards but it increased energy retention (P=0.04). Time to recover 50% of 13C from dietary glucose as expired 13CO2 was higher in RFI+ piglets before inducing inflammation but decreased after to the level of RFI− piglets (P<0.01). Oxidation of U-13C-glucose tended to slightly increased in RFI− piglets and to decreased in RFI+ piglets (P=0.10) because of CFA. Additionally, RFI− piglets had a lower respiratory quotient during the 1st day following the CFA injection whereas RFI+ piglets tended to have a higher respiratory quotient. In conclusion, selection for RFI during the fattening period also affected the energy metabolism of pigs during earlier stages of growth. The effects of CFA injection were moderated in both lines but the most efficient animals (RFI−) exhibited a marked re-orientation of nutrients only during the 1st day after CFA, and seemed to recover thereafter, whereas the less efficient piglets expressed a more prolonged alteration of their metabolism.

Keywords

pigletresidual feed intakeheat productionnutrient oxidationinflammation
Type
Research Article
Information
animal , Volume 9 , Issue 10 , October 2015 , pp. 1653 - 1661
Copyright
© The Animal Consortium 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

AOAC 1990. Official methods of analysis, 15th edition. AOAC, Arlington, VA, USA.Google Scholar
Barea, R, Dubois, S, Gilbert, H, Sellier, P, van Milgen, J and Noblet, J 2010. Energy utilization in pigs selected for high and low residual feed intake. Journal of Animal Science 88, 2062–2072.Google Scholar
Boddicker, N, Gabler, NK, Spurlock, ME, Nettleton, D and Dekkers, JCM 2011a. Effects of ad libitum and restricted feed intake on growth performance and body composition of Yorkshire pigs selected for reduced residual feed intake. Journal of Animal Science 89, 40–51.Google Scholar
Boddicker, N, Gabler, NK, Spurlock, ME, Nettleton, D and Dekkers, JCM 2011b.Effects of ad libitum and restricted feeding on early production performance and body composition of Yorkshire pigs selected for reduced residual feed intake. Animal 5, 1344–1353.Google Scholar
Brouwer, E 1965. Report of sub-comittee on constants and factors. In Energy metabolism (ed. KL Blaxter), pp. 441–443. Academic Press, London, UK.Google Scholar
Bunter, KL, Cai, W, Johnston, DJ and Dekkers, JCM 2010. Selection to reduce residual feed intake in pigs produces a correlated response in juvenile insulin-like growth factor-I concentration. Journal of Animal Science 88, 1973–1981.Google Scholar
Chwalibog, A and Thorbek, G 2000. Estimation of net nutrient oxydation and lipogenesis in growing pigs. Archives of Animal Nutrition 53, 253–271.Google Scholar
Cruzen, SM, Harris, AJ, Hollinger, K, Punt, RM, Grubbs, JK, Selsby, JT, Dekkers, JCM, Gabler, NK, Lonergan, SM and Huff-Lonergan, E 2013. Evidence of decreased muscle protein turnover in gilts selected for low residual feed intake. Journal of Animal Science 91, 4007–4016.Google Scholar
Damgaard, BM, Dalgaard, TS, Larsen, T, Hedemann, MS and Hansen, SW 2012. The effects of feed restriction on physical activity, body weight, physiology, haematology and immunology in female mink. Research in Veterinary Science 93, 936–942.Google Scholar
de Haer, LCM, Luiting, P and Aarts, HLM 1993. Relations among individual (residual) feed intake, growth performance and feed intake pattern of growing pigs in group housing. Livestock Production Science 36, 233–253.Google Scholar
Edwards, JF and Slauson, DO 1983. Complete Freund’s adjuvant-induced pneumonia in swine: a model of interstitial lung disease. Journal of Comparative Pathology 93, 353–361.Google Scholar
Faure, J, Lefaucheur, L, Bonhomme, N, Ecolan, P, Meteau, K, Coustard, SM, Kouba, M, Gilbert, H and Lebret, B 2013. Consequences of divergent selection for residual feed intake in pigs on muscle energy metabolism and meat quality. Meat Science 93, 37–45.Google Scholar
Gilbert, H and Dekkers, JCM 2013. Improvement of feed efficiency: lessons from residual feed intake studies in pigs: part 1. In 64th Annual Meeting of the European Federation of Animal Science, pp. 589. Wageningen Academic Publishers, Wageningen, NL.Google Scholar
Gilbert, H, Bidanel, JP, Gruand, J, Caritez, JC, Billon, Y, Guillouet, P, Lagant, H, Noblet, J and Sellier, P 2007. Genetic parameters for residual feed intake in growing pigs, with emphasis on genetic relationships with carcass and meat quality traits. Journal of Animal Science 85, 3182–3188.Google Scholar
Herd, RM and Arthur, PF 2009. Physiological basis for residual feed intake. Journal of Animal Science 87, E64–E71.Google Scholar
Klasing, KC and Barnes, DM 1988. Decreased amino acid requirements of growing chicks due to immunologic stress. The Journal of Nutrition 118, 1158–1164.CrossRefGoogle ScholarPubMed
Klasing, KC and Iseri, VJ 2013. Recent advances in understanding the interactions between nutrients and immunity in farm animals. In Energy and protein metabolism and nutrition in sustainable animal production (ed. JW Oltjen, E Kebreab and H Lapierre), pp. 353–359. Wageningen Academic Publishers, Wageningen, NL.Google Scholar
Koch, RM, Swiger, LA, Chambers, D and Gregory, KE 1963. Efficiency of feed use in beef cattle. Journal of Animal Science 22, 486–494.Google Scholar
Labussière, E, Dubois, S, van Milgen, J and Noblet, J 2013. Partitioning of heat production in growing pigs as a tool to improve the determination of efficiency of energy utilization. Frontiers in Physiology 4.Google Scholar
Le Floc’h, N, Melchior, D and Seve, B 2008. Dietary tryptophan helps to preserve tryptophan homeostasis in pigs suffering from lung inflammation. Journal of Animal Science 86, 3473–3479.CrossRefGoogle ScholarPubMed
Le Floc’h, N, Deblanc, C, Cariolet, R, Gautier-Bauchardon, AV, Merlot, E and Simon, G 2014. Effect of feed restriction on performance and postprandial nutrient metabolims in pigs co-infected with Mycoplasma hyopneumoniae and Swine influenza virus. PLoS One 9, e104605.Google Scholar
Le Naou, T, Le Floc’h, N, Louveau, I, Gilbert, H and Gondret, F 2012. Metabolic changes and tissue responses to selection on residual feed intake in growing pigs. Journal of Animal Science 90, 4771–4780.Google Scholar
Melchior, D, Seve, B and Le Floc’h, N 2004. Chronic lung inflammation affects plasma amino acid concentrations in pigs. Journal of Animal Science 82, 1091–1099.CrossRefGoogle ScholarPubMed
Moon, HK, Han, IK, Gentry, JL, Parmentier, HK and Schrama, JW 1999. Effect of chronic inflammation on energy metabolism and growth performance in weanling piglets. Asian-Australian Journal of Animal Sciences 12, 174–179.CrossRefGoogle Scholar
Montagne, L, Loisel, F, Le Naou, T, Gondret, F, Gilbert, H and Le Gall, M 2014. Difference in short-term responses to a high-fiber diet in pigs divergently selcted for residual feed intake. Journal of Animal Science 92, 1512–1523.Google Scholar
Njaa, LR 1961. Determination of protein digestibility with titanium dioxide as indicator substance. Acta Agricultura Scandinavia 11, 227–241.Google Scholar
Noblet, J, Karege, C, Dubois, S and van Milgen, J 1999. Metabolic utilization of energy and maintenance requirements in growing pigs: effects of sex and genotype. Journal of Animal Science 77, 1208–1216.Google Scholar
Rakhshandeh, A, Htoo, JK and de Lange, CFM 2010. Immune system stimulation of growing pigs does not alter apparent ileal amino acid digestibility but reduces the ratio between whole body nitrogen and sulfur retention. Livestock Science 134, 21–23.Google Scholar
Rauw, WM, Kanis, E, Noordhuizen-Stassen, EN and Grommers, FJ 1998. Undesirable side effects of selection for high production efficiency in farm animals: a review. Livestock Production Science 56, 15–33.CrossRefGoogle Scholar
Rauw, WM, Soler, J, Tibau, J, Reixach, J and Raya, LG 2006. The relationship between residual feed intake and feed intake behavior in group-housed Duroc barrows. Journal of Animal Science 84, 956–962.Google Scholar
Renaudeau, D, Frances, G, Dubois, S, Gilbert, H and Noblet, J 2013. Effect of thermal heat stress on energy utilization in two lines of pigs divergently selected for residual feed intake. Journal of Animal Science 91, 1162–1175.Google Scholar
Sadler, LJ, Johnson, AK, Lonergan, SM, Nettleton, D and Dekkers, JCM 2011. The effect of selection for residual feed intake on general behavioral activity and the occurrence of lesions in Yorkshire gilts. Journal of Animal Science 89, 258–266.CrossRefGoogle ScholarPubMed
Sandberg, FB, Emmans, GC and Kyriazakis, I 2007. The effects of pathogen challenges on the performance of naive and immune animals: the problem of prediction. Animal 1, 67–86.Google Scholar
SAS 2004. SAS/STAT® 9.1 user’s guide. SAS Institute Inc, New York, USA.Google Scholar
Sauvant, D, Perez, JM and Tran, G 2002. Tables de composition et de valeur nutritive des matières premières destinées aux animaux d’élevage. INRA Editions, Paris, France.Google Scholar
Sellier, P, Billon, Y, Riquet, J, Lagant, H, Calderon, JA, Guillouet, P, Bidanel, JP, Noblet, J and Gilbert, H 2010. Six générations de sélection divergente pour la consommation journalière résiduelle chez le porc en croissance: réponses corrélatives sur les caractères de reproduction des truies et synthèse des réponses sur les caractères de production. In 42èmes Journées de la Recherche Porcine, pp. 167–172, IFIP, Paris, France.Google Scholar
van Milgen, J and Noblet, J 2000. Modelling energy expenditure in pigs. In Modelling nutrient utilization in farm animals (ed. JP McNamara, J France and DE Beever), pp. 103–114. CAB International, Oxon, UK.Google Scholar
van Milgen, J, Noblet, J, Dubois, S and Bernier, JF 1997. Dynamic aspects of oxygen consumption and carbon dioxide production in swine. British Journal of Nutrition 78, 397–410.Google Scholar
Vermorel, M, Bouvier, JC, Bonnet, Y and Fauconneau, G 1973. Construction et fonctionnement de deux chambres respiratoires du type “circuit ouvert” pour jeunes bovins. Annales de Biologie Animale Biochimie Biophysique 13, 659–681.Google Scholar
Young, JM, Cai, W and Dekkers, JCM 2011. Effect of selection for residual feed intake on feeding behavior and daily feed intake patterns in Yorkshire swine. Journal of Animal Science 89, 639–647.Google Scholar