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Precursors for liver gluconeogenesis in periparturient dairy cows*

Published online by Cambridge University Press:  03 July 2013

M. Larsen  and
N. B. Kristensen
M. Larsen*
Affiliation:
Department of Animal Science, Aarhus University, Foulum, DK-8830 Tjele, Denmark
N. B. Kristensen
Affiliation:
Department of Animal Science, Aarhus University, Foulum, DK-8830 Tjele, Denmark
*
†E-mail: Mogens.Larsen@agrsci.dk
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Abstract

The review is based on a compiled data set from studies quantifying liver release of glucose concomitant with uptake of amino acids (AA) and other glucogenic precursors in periparturient dairy cows. It has become dogma that AAs are significant contributors to liver gluconeogenesis in early lactation, presumably accounting for the observed lack of glucogenic precursors to balance estimated glucose need. Until recently, there has been paucity in quantitative data on liver nutrient metabolism in the periparturient period. Propionate is the quantitatively most important glucogenic precursor throughout the periparturient period. However, the immediate post partum increment in liver release of glucose is not followed by an equivalent increment in propionate uptake, because of the lower rate of increment in feed intake compared with the rate of increment in requirements for milk synthesis. The quantitative data on liver metabolism of AA do not support the hypothesis that the rapid post partum increase in net liver release of glucose is supported by increased utilisation of AA for gluconeogenesis. Only alanine is likely to contribute to liver release of glucose through its role in the inter-organ transfer of nitrogen from catabolised AA. AAs seem to be prioritised for anabolic purposes, indicating the relevance of investigating effects of supplying additional protein to post partum dairy cows. Combining data from quantitative and qualitative experimental techniques on L-lactate metabolism point to the conclusion that the quantitatively most important adaptation of metabolism to support the increased glucose demand in the immediate post partum period is endogenous recycling of glucogenic carbon through lactate. This is mediated by a dual site of adaptation of metabolism in the liver and in the peripheral tissues, where the liver affinity for L-lactate is increased and glucose metabolism in peripheral tissues is shifted towards L-lactate formation over complete oxidation.

Keywords

gluconeogenesisamino acidglucosecowparturition
Type
Physiology and functional biology of systems
Information
animal , Volume 7 , Issue 10 , October 2013 , pp. 1640 - 1650
Copyright
Copyright © The Animal Consortium 2013 

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Footnotes

*

The present review is based on an invited presentation at the 62nd annual EAAP meeting in Stavanger, Norway.

References

Agca, C, Greenfield, RB, Hartwell, JR, Donkin, SS 2002. Cloning and characterization of bovine cytosolic and mitochondrial PEPCK during transition to lactation. Physiological Genomics 11, 53–63.Google Scholar
Amaral, DM, Veenhuizen, JJ, Drackley, JK, Cooley, MH, McGilliard, AD, Young, JW 1990. Metabolism of propionate, glucose, and carbon dioxide as affected by exogenous glucose in dairy cows at energy equilibrium. Journal of Dairy Science 73, 1244–1254.Google Scholar
Aschenbach, JR, Kristensen, NB, Donkin, SS, Hammon, HM, Penner, GB 2010. Gluconeogenesis in dairy cows: the secret of making sweet milk from sour dough. IUBMB Life 62, 869–877.Google Scholar
Bach, A, Huntington, GB, Calsamiglia, S, Stern, MD 2000. Nitrogen metabolism of early lactation cows fed diets with two different levels of protein and different amino acid profiles. Journal of Dairy Science 83, 2585–2595.CrossRefGoogle ScholarPubMed
Baird, GD, Van Der Walt, JG, Bergman, EN 1983. Whole-body metabolism of glucose and lactate in productive sheep and cows. British Journal of Nutrition 50, 249–265.Google Scholar
Baird, GD, Lomax, MA, Symonds, HW, Shaw, SR 1980. Net hepatic and splanchnic metabolism of lactate, pyruvate and propionate in dairy cows in vivo in relation to lactation and nutrient supply. Biochemical Journal 186, 47–57.Google Scholar
Bauman, DE 2000. Regulation of nutrient partitioning during lactation: homeostasis and homeorhesis revisited. In Ruminant physiology: digestion, metabolism, growth and reproduction (ed. PB Cronje), pp. 311–328. CAB International, Wallingford, UK.Google Scholar
Bender, DA 1985. Amino acid metabolism. John Wiley & Sons, Chichester, UK.Google Scholar
Bennink, MR, Mellenberger, RW, Frobish, RA, Bauman, DE 1972. Glucose oxidation and entry rate as affected by initiation of lactation. Journal of Dairy Science 55 (Suppl. 1), 172–173.Google Scholar
Benson, JA, Reynolds, CK, Aikman, PC, Lupoli, B, Beever, DE 2002. Effects of abomasal vegetable oil infusion on splanchnic nutrient metabolism in lactating dairy cows. Journal of Dairy Science 85, 1804–1814.Google Scholar
Bergman, EN 1990. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiological Reviews 70, 567–590.CrossRefGoogle ScholarPubMed
Bergman, EN, Heitmann, RN 1978. Metabolism of amino acids by gut, liver, kidneys, and peripheral tissues. Federation Proceedings 37, 1228–1232.Google Scholar
Berthiaume, R, Thivierge, MC, Patton, RA, Dubreuil, P, Stevenson, M, McBride, BW, Lapierre, H 2006. Effect of ruminally protected methionine on splanchnic metabolism of amino acids in lactating dairy cows. Journal of Dairy Science 89, 1621–1634.CrossRefGoogle ScholarPubMed
Bertics, SJ, Grummer, RR, Cadorniga-Valino, C, Stoddard, EE 1992. Effect of prepartum dry matter intake on liver triglyceride concentration and early lactation. Journal of Dairy Science 75, 1914–1922.Google Scholar
Blouin, JP, Bernier, JF, Reynolds, CK, Lobley, GE, Dubreuil, P, Lapierre, H 2002. Effect of supply of metabolizable protein on splanchnic fluxes of nutrients and hormones in lactating dairy cows. Journal of Dairy Science 85, 2618–2630.Google Scholar
Brockman, RP, Bergman, EN 1975. Effect of glucagon on plasma alanine and glutamine metabolism and hepatic gluconeogenesis in sheep. American Journal of Physiology 228, 1628–1633.CrossRefGoogle ScholarPubMed
Brockman, RP, Bergman, EN, Joo, PK, Manns, JG 1975. Effects of glucagon and insulin on net hepatic-metabolism of glucose precursors in sheep. American Journal of Physiology 229, 1344–1350.Google Scholar
Bruckental, I, Oldham, JD, Sutton, JD 1980. Glucose and urea kinetics in cows in early lactation. British Journal of Nutrition 44, 33–45.Google Scholar
Casse, EA, Rulquin, H, Huntington, GB 1994. Effect of mesenteric vein infusion of propionate on splanchnic metabolism in primiparous holstein cows. Journal of Dairy Science 77, 3296–3303.CrossRefGoogle ScholarPubMed
Dalbach, KF, Larsen, M, Raun, BML, Kristensen, NB 2011. Effects of supplementation with 2-hydroxy-4-(methylthio)-butanoic acid isopropyl ester on splanchnic amino acid metabolism and essential amino acid mobilization in postpartum transition Holstein cows. Journal of Dairy Science 94, 3913–3927.CrossRefGoogle ScholarPubMed
Danfær, A, Tetens, V, Agergaard, N 1995. Review and an experimental study on the physiological and quantitative aspects of gluconeogenesis in lactating ruminants. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 111, 201–210.CrossRefGoogle Scholar
Doepel, L, Lapierre, H, Kennelly, JJ 2002. Peripartum performance and metabolism of dairy cows in response to prepartum energy and protein intake. Journal of Dairy Science 85, 2315–2334.CrossRefGoogle ScholarPubMed
Doepel, L, Lobley, GE, Bernier, JF, Dubreuil, P, Lapierre, H 2009. Differences in splanchnic metabolism between late gestation and early lactation dairy cows. Journal of Dairy Science 92, 3233–3243.Google Scholar
Drackley, JK, Overton, TR, Douglas, GN 2001. Adaptations of glucose and long-chain fatty acid metabolism in liver of dairy cows during the periparturient period. Journal of Dairy Science 84 (E. Suppl.), E100–E112.Google Scholar
Ewaschuk, JB, Naylor, JM, Zello, GA 2005. D-lactate in human and ruminant metabolism. Journal of Nutrition 135, 1619–1625.Google Scholar
Gibb, MJ, Ivings, WE, Dhanoa, MS, Sutton, JD 1992. Changes in body components of autumn-calving Holstein-Friesian cows over the first 29 weeks of lactation. Animal Production 55, 339–360.Google Scholar
Greenfield, RB, Cecava, MJ, Donkin, SS 2000. Changes in mRNA expression for gluconeogenic enzymes in liver of dairy cattle during the transition to lactation. Journal of Dairy Science 83, 1228–1236.CrossRefGoogle ScholarPubMed
Harmon, DL, Britton, RA, Prior, RL 1983. Influence of diet on glucose turnover and rates of gluconeogenesis, oxidation and turnover of D-(-)-lactate in the bovine. Journal of Nutrition 113, 1842–1850.Google Scholar
Herbein, JH, Aiello, RJ, Eckler, LI, Pearson, RE, Akers, RM 1985. Glucagon, insulin, growth hormone, and glucose concentrations in blood plasma of lactating dairy cows. Journal of Dairy Science 68, 320–325.CrossRefGoogle ScholarPubMed
Holtenius, P, Olsson, G, Björkman, C 1993. Periparturient concentrations of insulin, glucagon and ketone bodies in dairy cows fed two different levels of nutrition and varying concentrate/roughage ratios. Journal of Veterinary Medicine Series A 40, 118–127.CrossRefGoogle ScholarPubMed
Huntington, GB, Reynolds, CK, Stroud, BH 1989. Techniques for measuring blood flow in splanchnic tissues of cattle. Journal of Dairy Science 72, 1583–1595.Google Scholar
Ingvartsen, KL, Andersen, JB 2000. Integration of metabolism and intake regulation: a review focusing on periparturient animals. Journal of Dairy Science 83, 1573–1597.Google Scholar
Katz, ML, Bergman, EN 1969. Simultaneous measurements of hepatic and portal venous blood flow in the sheep and dog. American Journal of Physiology 216, 946–952.Google Scholar
Kristensen, NB, Røjen, BA, Raun, BML, Storm, AC, Puggaard, L, Larsen, M 2009. Hepatic acetylation of the blood flow marker p-aminohippuric acid affect measurement of hepatic blood flow in cattle. In Ruminant physiology. Proceeding of the XIth international symposium on ruminant physiology (ed. Y Chilliard, F Glasser, Y Faulconnier, F Bocquier, I Veissier and M Doreau), pp. 558–559. Wageningen Academic Publishers, Wageningen, The Netherlands.Google Scholar
Kuhla, B, Nürnberg, G, Albrecht, D, Görs, S, Hammon, HM, Metges, CC 2011. Involvement of skeletal muscle protein, glycogen, and fat metabolism in the adaptation on early lactation dairy cows. Journal of Proteome Research 10, 4252–4262.CrossRefGoogle Scholar
Lapierre, H, Berthiaume, R, Raggio, G, Thivierge, MC, Doepel, L, Pacheco, D, Dubreuil, P, Lobley, GE 2005. The route of absorbed nitrogen into milk protein. Animal Science 80, 11–22.Google Scholar
Larsen, M, Kristensen, NB 2008. Use of inter-organ glycerol fluxes to assess abdominal versus peripheral fat mobilization in transition dairy cows. Journal of Dairy Science 91 (Suppl. 1), 88.Google Scholar
Larsen, M, Kristensen, NB 2009a. Effect of abomasal glucose infusion on splanchnic amino acid metabolism in periparturient dairy cows. Journal of Dairy Science 92, 3306–3318.Google Scholar
Larsen, M, Kristensen, NB 2009b. Effect of abomasal glucose infusion on splanchnic and whole body glucose metabolism in periparturient dairy cows. Journal of Dairy Science 92, 1071–1083.Google Scholar
Larsen, M, Kristensen, NB 2012. Effects of glucogenic and ketogenic feeding strategies on splanchnic glucose and amino acid metabolism in postpartum transition Holstein cows. Journal of Dairy Science 95, 5946–5960.CrossRefGoogle ScholarPubMed
Lin, ECC 1977. Glycerol utilization and its regulation in mammals. Annual Review of Biochemistry 46, 765–795.Google Scholar
Lobley, GE, Lapierre, H 2003. Post-absorptive metabolism of amino acids. In:Progress in research on energy and protein metabolism. EAAP publication no. 109 (ed. WB Souffrant and CC Metges), pp. 737–756. Wageningen Academic Publishers, Wageningen, NL.Google Scholar
Lomax, MA, Baird, GD 1983. Blood flow and nutrient exchange across the liver and gut of the dairy cow effects of lactation and fasting. British Journal of Nutrition 49, 481–496.Google Scholar
Loor, JJ 2010. Genomics of metabolic adaptations in the peripartal cow. Animal 4, 1110–1139.Google Scholar
Nafikov, RA, Ametaj, BN, Bobe, G, Koehler, K, Young, JW, Beitz, DC 2008. Prevention of fatty liver in transition dairy cows by subcutaneous injections of glucagon. Journal of Dairy Science 89, 1533–1545.Google Scholar
Osman, MA, Allen, PS, Bobe, G, Coetzee, JF, Abuzaid, A, Koehler, K, Beitz, DC 2010. Chronic metabolic responses of postpartal dairy cows to subcutaneous glucagon injections, oral glycerol, or both. Journal of Dairy Science 93, 3505–3512.CrossRefGoogle ScholarPubMed
Overton, TR 1998. Substrate utilization for hepatic gluconeogenesis in the transition dairy cow. In Proceedings of the 1998 Cornell nutrition conference for feed manufactures, pp. 237–246. Cornell University, Ithaca, NY.Google Scholar
Overton, TR, Drackley, JK, Ottemann-Abbamonte, CJ, Beaulieu, AD, Emmert, LS, Clark, JH 1999. Substrate utilization for hepatic gluconeogenesis is altered by increased glucose demand in ruminants. Journal of Animal Science 77, 1940–1951.Google Scholar
Park, AF, Shirley, JE, Titgemeyer, EC, Cochran, RC, DeFrain, JM, Wickersham, EE, Johnson, DE 2010. Characterization of plasma metabolites in Holstein dairy cows during the periparturient period. International Journal of Dairy Science 5, 253–263.Google Scholar
Raun, BML, Kristensen, NB 2011. Metabolic effects of feeding ethanol or propanol to postpartum transition Holstein cows. Journal of Dairy Science 94, 2566–2580.Google Scholar
Reynolds, CK 2002. Economics of visceral energy metabolism in ruminants: toll keeping or internal revenue service? Journal of Animal Science 80 (E-Suppl. 2), E74–E84.Google Scholar
Reynolds, CK, Huntington, GB, Tyrrell, HF, Reynolds, PJ 1988a. Net metabolism of volatile fatty acids, D-β-hydroxybutyrate, nonesterified fatty acids, and blood gasses by portal-drained viscera and liver of lactating holstein cows. Journal of Dairy Science 71, 2395–2405.Google Scholar
Reynolds, CK, Huntington, GB, Tyrrell, HF, Reynolds, PJ 1988b. Net portal-drained visceral and hepatic metabolism of glucose, L-lactate, and nitrogenous compounds in lactating holstein cows. Journal of Dairy Science 71, 1803–1812.CrossRefGoogle ScholarPubMed
Reynolds, CK, Aikman, PC, Lupoli, B, Humphries, DJ, Beever, DE 2003. Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation. Journal of Dairy Science 86, 1201–1217.Google Scholar
Reynolds, CK, Durst, B, Lupoli, B, Humphries, DJ, Beever, DE 2004. Visceral tissue mass and rumen volume in dairy cows during the transition from late gestation to early lactation. Journal of Dairy Science 87, 961–971.CrossRefGoogle ScholarPubMed
She, P, Hippen, AR, Young, JW, Lindberg, GL, Beitz, DC, Richardson, LF, Tucker, RW 1999. Metabolic responses of lactating dairy cows to 14-day intravenous infusions of glucagon. Journal of Dairy Science 82, 1118–1127.Google Scholar
Veenhuizen, JJ, Russell, RW, Young, JW 1988. Kinetics of metabolism of glucose, propionate and CO2 in steers as affected by injection of phlorizin and feeding propionate. Journal of Nutrition 118, 1366–1375.Google Scholar