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DNA polymorphisms of apolipoprotein B in the population of Senegal

Published online by Cambridge University Press:  01 November 1997

M. CHAUFFERT ,
J. LARGHERO ,
K. NGOHOU-BOTUM ,
A. CISSE ,
D. CHEVENNE  and
F. TRIVIN
M. CHAUFFERT
Affiliation:
Service de Biochimie, Hôpital Saint-Joseph, 185, rue Raymond Losserand, 75674 Paris cedex 14, France
J. LARGHERO
Affiliation:
Service de Biochimie, Hôpital Saint-Joseph, 185, rue Raymond Losserand, 75674 Paris cedex 14, France
K. NGOHOU-BOTUM
Affiliation:
Service de Biochimie, Hôpital Saint-Joseph, 185, rue Raymond Losserand, 75674 Paris cedex 14, France
A. CISSE
Affiliation:
Laboratoire de Physique Pharmaceutique, Faculté de Médecine et de Pharmacie, Université Cheikh Anta Diop, BP 2238, Dakar, Sénégal
D. CHEVENNE
Affiliation:
Service de Biochimie, Hôpital Saint-Joseph, 185, rue Raymond Losserand, 75674 Paris cedex 14, France
F. TRIVIN
Affiliation:
Service de Biochimie, Hôpital Saint-Joseph, 185, rue Raymond Losserand, 75674 Paris cedex 14, France
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Abstract

Three apolipoprotein B (apoB) genetic polymorphisms, the XbaI, MspI and EcoRI restriction fragment length polymorphisms (RFLPs), were analysed for 221 individuals in Senegal by polymerase chain reaction. Allelic frequency determination revealed that this population has 0.79 XbaI− (X−), 0.96 MspI+ (M+), and 0.89 EcoRI+ (E+). Major genotypes were X−/X− (0.62), M+/M+ (0.92) and E+/E+ (0.80). The XbaI allele frequency is different (p<10−9) from that in Caucasians (0.47) and from that in Mongoloids (0.98). Significant differences between Senegalese and Caucasians, and between Senegalese and Mongoloids were also observed for the EcoRI and MspI alleles of the apoB genes.

Type
SHORT COMMUNICATIONS
Information
Annals of Human Genetics , Volume 61 , Issue 6 , November 1997 , pp. 525 - 529
Copyright
© University College London 1997

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