Molecular characterization of isochromosomes of Xq

R. S. JAMES; P. DALTON; K. GUSTASHAW; D. J. WOLFF; H. F. WILLARD; C. MITCHELL; P. A. JACOBS

doi:10.1017/S0003480097006519

Abstract

We have undertaken a study of 35 patients with i(Xq) to determine whether those that are maternally derived originate by similar mechanisms to those that are paternally derived. Isochromosome formation is not associated with increased parental age and >90% of i(Xq) contain proximal Xp sequences suggesting that centromere misdivision is not a common mechanism of formation. Our results indicate that the majority of i(Xq) originate from a single X chromosome and the usual mechanisms of formation do not appear to differ according to the parent of origin.

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Molecular characterization of isochromosomes of Xq

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