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Consequences of a network view for genetic association studies

Published online by Cambridge University Press:  29 June 2010

Sophie van der Sluis ,
Kees-Jan Kan  and
Conor V. Dolan
Sophie van der Sluis
Affiliation:
Department of Functional Genomics, Center for Neurogenomics and Cognitive Research (CNCR), Vrije University Amsterdam, 1081 HV Amsterdam, The Netherlands. sophie.van.der.sluis@cncr.vu.nl
Kees-Jan Kan
Affiliation:
Department of Psychology, Faculty of Social and Behavioural Sciences, University of Amsterdam, 1018 WB Amsterdam, The Netherlands. k.j.kan@uva.nlhttp://home.uva.nl/kees-jan.kan/c.v.dolan@uva.nlhttp://users.fmg.uva.nl/cdolan/
Conor V. Dolan
Affiliation:
Department of Psychology, Faculty of Social and Behavioural Sciences, University of Amsterdam, 1018 WB Amsterdam, The Netherlands. k.j.kan@uva.nlhttp://home.uva.nl/kees-jan.kan/c.v.dolan@uva.nlhttp://users.fmg.uva.nl/cdolan/
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Abstract

Cramer et al's proposal to view mental disorders as the outcome of network dynamics among symptoms obviates the need to invoke latent traits to explain co-occurrence of symptoms and syndromes. This commentary considers the consequences of such a network view for genetic association studies.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 33 , Issue 2-3 , June 2010 , pp. 173 - 174
Copyright
Copyright © Cambridge University Press 2010

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