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Acute effects of meal fatty acids on postprandial NEFA, glucose and apo E response: implications for insulin sensitivity and lipoprotein regulation?

Published online by Cambridge University Press:  08 March 2007

Kim G. Jackson ,
Emma J. Wolstencroft ,
Paul A. Bateman ,
Parveen Yaqoob  and
Christine M. Williams
Kim G. Jackson*
Affiliation:
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, RG6 6AP, UK
Emma J. Wolstencroft
Affiliation:
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, RG6 6AP, UK
Paul A. Bateman
Affiliation:
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, RG6 6AP, UK
Parveen Yaqoob
Affiliation:
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, RG6 6AP, UK
Christine M. Williams
Affiliation:
Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Reading, RG6 6AP, UK
*
*Corresponding author: Dr Kim Jackson, fax +44 (0) 118 931 0080, email k.g.jackson@reading.ac.uk
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Abstract

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Our aim was to determine whether meal fatty acids influence insulin and glucose responses to mixed meals and whether these effects can be explained by variations in postprandial NEFA and Apo, which regulate the metabolism of triacylglycerol-rich lipoproteins (Apo C and E). A single-blind crossover study examined the effects of single meals enriched in saturated fatty acids SFA), n-6 PUFA and MUFA on plasma metabolite and insulin responses. The triacylglycerol response following the PUFA meal showed a lower net incremental area under the curve than following the SFA and MUFA meals (P<0·007). Compared with the SFA meal, the PUFA meal showed a lower net incremental area under the curve for the NEFA response from initial suppression to the end of the postprandial period (180–480 min; P<0·02), and both PUFA and MUFA showed a lower net incremental glucose response (P<0·02), although insulin concentrations were similar between meals. The pattern of the Apo E response was also different following the SFA meal (P<0·02). There was a significant association between the net incremental NEFA (180–480 min) and glucose response (rs=0·409, P=0·025), and in multiple regression analysis the NEFA response accounted for 24 % of the variation in glucose response. Meal SFA have adverse effects on the postprandial glucose response that may be due to greater elevations in NEFA arising from differences in the metabolism of SFA- v. PUFA- and MUFA-rich lipoproteins. Elevated Apo E responses to high-SFA meals may have important implications for the hepatic metabolism of triacylglycerol-rich lipoproteins.

Keywords

TriacylglycerolInsulinApolipoproteinsNEFA
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 5 , May 2005 , pp. 693 - 700
Copyright
Copyright © The Nutrition Society 2005

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